Multispike train analysis

Abeles, Moshe; Goldstein, Moïse H.

doi:10.1109/proc.1977.10559

Cited by 310 publications

(198 citation statements)

References 32 publications

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“…In addition, the electrode output was also bandpass filtered (monkey Cu, 300 -6000 Hz; monkeys S, Cl, and Y, 1-6000 Hz; four pole Butterworth filter; MCP-plus 2.8) and continuously sampled at 24 kHz (AlphaMap 5.0). The continuous sampling of the electrode output was also subjected to an off-line spike-sorting procedure (AlphaSort 3.8) based on principal-component analysis of the spike patterns (Abeles and Goldstein, 1977) (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

Functional Correlations between Neighboring Neurons in the Primate Globus Pallidus Are Weak or Nonexistent

Bar‐Gad¹,

Heimer²,

Ritov³

et al. 2003

J. Neurosci.

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The anatomical structure of the basal ganglia displays topographical organization and massive funneling of neuronal projections toward the globus pallidus as well as an axonal collateral system within this nucleus. This structure suggests the formation of correlations between the spiking activities of pallidal cells. Nevertheless, previous studies of remote neurons in the pallidum have reported uncorrelated spiking activity. These correlation results may be challenged, because remote pallidal neurons may be located in different pallidal territories. To further test the independence of pallidal activity, we studied the spiking activity of neighboring pairs recorded by the same electrodes. A narrow peak dominated the correlations of all pairs of neurons recorded on the same electrode. This type of peak is classically interpreted as a sign of strong common input. However, recent mathematical analysis shows that such peaks may derive from a technical inability to detect overlapping spikes by spike-sorting techniques. A long-term shallow trough in the correlation of neighboring neurons may also result from the same effect, which we have termed the "shadowing effect." A comparison of the expected shadowing effect with the actual correlations suggests that no real correlations exist between 93.9% of neighboring pallidal pairs. The remaining 6.1% of the pairs display symmetric long-term positive correlations centered on time 0. Thus, functional interactions between neighboring pallidal neurons donotdisplayanysignificantdifferencesfromtheinteractionsbetweenphysicallyremoteneuronsinthisbrainarea.Moreover,thecombination of anatomical data and current physiological results suggests an active decorrelating process performed in the basal ganglia.

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Section: Methodsmentioning

confidence: 99%

Functional Correlations between Neighboring Neurons in the Primate Globus Pallidus Are Weak or Nonexistent

Bar‐Gad¹,

Heimer²,

Ritov³

et al. 2003

J. Neurosci.

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“…The number and kind of different waveforms in an extracellular recording can be determined by the means of the principal component analysis (PCA), followed by cluster analysis. First, Abeles and Goldstein (1977) applied this technique to extract the activity of individual units from a multiunit recording. In contrast, we used it for separating isolated prepotentials (IPP) from pre&action potential compounds in recordings from single units in the MNTB.…”

Section: Data Collection and Analysismentioning

confidence: 99%

The Medial Nucleus of the Trapezoid Body in the Gerbil Is More Than a Relay: Comparison of Pre- and Postsynaptic Activity

Kopp-Scheinpflug

Lippe

Dörrscheidt

et al. 2003

JARO - Journal of the Association for Research in Otolaryngolog

114

158

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The medial nucleus of the trapezoid body (MNTB) plays an important role in the processing of interaural intensity differences, a feature that is critical for the localization of sound sources. It is generally believed that the MNTB functions primarily as a passive relay in converting excitatory input originating from the contralateral cochlear nucleus (CN) into an inhibitory input to the ipsilateral lateral superior olive. However, studies showing that the MNTB itself is also the target of inhibitory input suggest that the MNTB may serve more than a sign-converting function. To examine the fidelity of signal transmission at the CN-MNTB synapse, presynaptic calyceal potentials (''prepotentials''), reflecting the excitatory input to the MNTB neuron, and postsynaptic action potentials were simultaneously monitored with the same electrode during in vivo extracellular recordings from the gerbil's MNTB. Presynaptic activity differed from postsynaptic activity in several respects: (1) Spontaneous and sound-evoked discharge rates were greater presynaptically than postsynaptically. (2) Frequency tuning was sharper postsynaptically than presynaptically. (3) Calyceal terminals and MNTB neurons both showed phasic-tonic response patterns to tonal stimulation, but the duration of the onset response and the level of the tonic component were reduced postsynaptically. (4) Phase-locking to sound frequencies up to 1 kHz was greater postsynaptically than presynaptically. (5) The rate-intensity characteristics of pre-and postsynaptic activities differed significantly from each other in half of the MNTB neurons. To test the hypothesis that acoustically evoked inhibition of MNTB neurons contributed to the relatively lower levels of postsynaptic discharge, two-tone stimulation was applied, wherein the response to one tone-burst, set at the neuron's characteristic frequency, can be reduced by addition of a second ''inhibitory'' tone. The inhibitory tone caused a much larger reduction in post-than in presynaptic activity, indicating an acoustically evoked inhibitory influence directly on MNTB units. These findings show that transmission at the CN-MNTB synapse does not occur in a fixed one-to-one manner and that the response of MNTB neurons reflects the integration of their excitatory and inhibitory inputs.

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“…The number of independent waveforms present in recordings of AVC N activity was determined by applying the principal component (PC) analysis, followed by a cluster analysis. This analysis was first introduced into neurophysiology by Abeles and Goldstein (1977) and has since found various applications in this field (Wiener and Richmond, 1999). Principal component analysis showed that waveform recordings of AVC N activity were separable into two distinctive components, i.e., complex waveforms (spike-preceding PPs plus postsynaptic spikes) and isolated PPs.…”

Section: Data Collection and Analysismentioning

confidence: 99%

Interaction of Excitation and Inhibition in Anteroventral Cochlear Nucleus Neurons That Receive Large Endbulb Synaptic Endings

et al. 2002

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Spherical bushy cells (SBCs) of the anteroventral cochlear nucleus (AVCN) receive their main excitatory input from auditory nerve fibers (ANFs) through large synapses, endbulbs of Held. These cells are also the target of inhibitory inputs whose function is not well understood. The present study examines the role of inhibition in the encoding of low-frequency sounds in the gerbil's AVCN. The presynaptic action potentials of endbulb terminals and postsynaptic action potentials of SBCs were monitored simultaneously in extracellular single-unit recordings in vivo. An input-output analysis of presynaptic and postsynaptic activity was performed for both spontaneous and acoustically driven activity. Two-tone stimulation and neuropharmacological experiments allowed the effects of neuronal inhibition and cochlear suppression on SBC activity to be distinguished.Ninety-one percent of SBCs showed significant neuronal inhibition. Inhibitory sidebands enclosed the high-or lowfrequency, or both, sides of the excitatory areas of these units; this was reflected as a presynaptic to postsynaptic increase in frequency selectivity of up to one octave. Inhibition also affected the level-dependent responses at the characteristic frequency. Although in all units the presynaptic recordings showed monotonic rate-level functions, this was the case in only half of the postsynaptic recordings. In the other half of SBCs, postsynaptic inhibitory areas overlapped the excitatory areas, resulting in nonmonotonic rate-level functions. The results demonstrate that the sound-evoked spike activity of SBCs reflects the integration of acoustically driven excitatory and inhibitory input. The inhibition specifically affects the processing of the spectral, temporal, and intensity cues of acoustic signals. Key words: prepotential units; endbulb of Held; cochlear suppression; neuronal inhibition; in vivo physiology; bicuculline; strychnine; gerbil; spherical bushy cells; cochlear nucleusThe cochlear nucleus consists of three subdivisions: the anteroventral cochlear nucleus (AVCN), the posteroventral cochlear nucleus, and the dorsal cochlear nucleus, each of which establishes the origins of several monaural and binaural ascending pathways (for review, see Irvine, 1986). It was believed previously that the AVCN serves primarily as a relay transmitting a highfidelity copy of the activity of the auditory nerve to more central auditory brainstem nuclei (Pfeiffer, 1966a,b;Rose et al., 1974). This was demonstrated by morphological data which show that the principal neurons of the AVCN, the spherical bushy cells (SBCs), are innervated by only two to four auditory nerve fibers (ANFs) that form large synaptic endbulbs on the somata of the neurons (Brawer and Morest, 1975;Ryugo and Sento, 1991;Bazwinsky et al., 1999). Because of this specific synaptic configuration, electrophysiological recordings using extracellular electrodes can detect the postsynaptic action potentials of SBCs together with a preceding "prepotential" (PP), indicating the presynaptic afferent ANF ...

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Multispike train analysis

Cited by 310 publications

References 32 publications

Functional Correlations between Neighboring Neurons in the Primate Globus Pallidus Are Weak or Nonexistent

Functional Correlations between Neighboring Neurons in the Primate Globus Pallidus Are Weak or Nonexistent

The Medial Nucleus of the Trapezoid Body in the Gerbil Is More Than a Relay: Comparison of Pre- and Postsynaptic Activity

Interaction of Excitation and Inhibition in Anteroventral Cochlear Nucleus Neurons That Receive Large Endbulb Synaptic Endings

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