Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach

Becker, Anne E.; Masthoff, Max; Claussen, Jing; Ford, Steven J.; Roll, Wolfgang; Burg, Matthias C.; Barth, Peter; Heindel, Walter; Schäfers, Michael; Eisenblätter, Michel; Wildgruber, Moritz

doi:10.1007/s00330-017-5002-x

Cited by 83 publications

(104 citation statements)

References 28 publications

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“…In malignant breast tissue, MSOT allowed the visualization of peripheral tumor vascularization, disruption of fat, and water tissue layers [31]. In addition, increased signals for hemoglobin were found in invasive breast cancer when compared to healthy breast tissue [30].…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

et al. 2020

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Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectral optoacoustic tomography (MSOT), these technologies have now moved closer to clinical applications. MSOT utilizes short-pulsed near-infrared laser light to induce thermoelastic expansion in targeted tissues. This results in acoustic pressure waves, which are used to resolve specific endo-and exogenous chromophores. Especially in the pediatric population, this non-invasive imaging approach might hold fundamental advantages compared to conventional cross-sectional imaging modalities. As this technology allows the visualization of quantitative molecular tissue composition at high spatial resolution non-invasively in sufficient penetration depth, it paves the way to personalized medicine in pediatric diseases.

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Section: Current Clinical Applicationsmentioning

confidence: 99%

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

et al. 2020

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“…Volumes were reconstructed with direct backprojection, while linear regression was used for spectral unmixing of HbR, HbO2 and ICG and visualised in real-time using viewMSOTc software (v1.2, iThera Medical, Munich, Germany). Detailed technical descriptions of the system have been published elsewhere [14].…”

Section: Msot Image Acquisition and Data Analysismentioning

confidence: 99%

Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device

Giacalone¹,

Yamamoto

Belva³

et al. 2020

JCM

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Identification of lymphatics by Indocyanine Green (ICG) lymphography in patients with severe lymphedema is limited due to the overlying dermal backflow. Nor can the method detect deep and/or small vessels. Multispectral optoacoustic tomography (MSOT), a real-time three-dimensional (3D) imaging modality which allows exact spatial identification of absorbers in tissue such as blood and injected dyes can overcome these hurdles. However, MSOT with a handheld probe has not been performed yet in lymphedema patients. We conducted a pilot study in 11 patients with primary and secondary lymphedema to test whether lymphatic vessels could be detected with a handheld MSOT device. In eight patients, we could not only identify lymphatics and veins but also visualize their position and contractility. Furthermore, deep lymphatic vessels not traceable by ICG lymphography and lymphatics covered by severe dermal backflow, could be clearly identified by MSOT. In three patients, two of which had advanced stage lymphedema, only veins but no lymphatic vessels could be identified. We found that MSOT can identify and image lymphatics and veins in real-time and beyond the limits of near-infrared technology during a single bedside examination. Given its easy use and high accuracy, the handheld MSOT device is a promising tool in lymphatic surgery.

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“…Importantly, optoacustic imaging allows visualization of tissue changes up to 8 cm in depth compared to fluorescence-based optical methods reaching tissue penetration of less than 1 cm. This modality has been applied in preclinical models and in patients to evaluate its feasibility to increase the diagnostic sensitivity in cancer patients [16,17]. In principle, it can also be implemented in detection of infectious agents e.g.…”

mentioning

confidence: 99%

Towards clinical application of non-invasive imaging to detect bacterial infections

Ohlsen

Hertlein

2018

Virulence

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In vivo imaging technologies offer a great potential for the diagnosis of difficult-to-treat bacterial infections. A major limitation of conventional imaging modalities is the lack of specificity to distinguish the site of bacterial infection from sterile inflammation. Targeted approaches like antibiotics linked to imaging tracers for detection of various bacterial pathogens or species-specific antibodies combined with anatomical imaging modalities are currently being evaluated to overcome this problem. Considering the recent progress in optical and targeted imaging that may accelerate preclinical development programs, clinical implementation of in vivo imaging modalities to detect bacterial infection foci becomes realistic in the future.

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Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach

Abstract: • A handheld MSOT probe enables real-time molecular imaging of the breast. • MSOT of healthy controls provides a reproducible reference for pathology identification. • MSOT parameters allows for differentiation of invasive carcinoma and healthy tissue.

Cited by 83 publications

References 28 publications

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device

Towards clinical application of non-invasive imaging to detect bacterial infections

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