Abstract:A miniature device enabling parallel in vivo detection of the neurotransmitter choline in multiple brain regions of freely behaving rodents is presented. This is achieved by combining a biosensor microprobe array with a custom-developed CMOS chip. Each silicon microprobe comprises multiple platinum electrodes that are coated with an enzymatic membrane and a permselective layer for selective detection of choline. The biosensors, based on the principle of amperometric detection, exhibit a sensitivity of 157 ± 35… Show more
“…The amperometric principle of operation was supported by a custom-made CMOS chip used to amplify, digitize, and multiplex the sensor signals, resulting in a detection limit for choline of 1 μm [6].…”
“…The amperometric principle of operation was supported by a custom-made CMOS chip used to amplify, digitize, and multiplex the sensor signals, resulting in a detection limit for choline of 1 μm [6].…”
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