Multisession transcranial direct current stimulation facilitates verbal learning and memory consolidation in young and older adults

Perceval, Garon; Martin, Andrew K.; Copland, David A.; Laine, Matti; Meinzer, Marcus

doi:10.1016/j.bandl.2020.104788

Cited by 33 publications

(51 citation statements)

References 65 publications

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“…The literature research yielded only three original articles [ 56 – 58 ], which were characterized by a high heterogeneity in the study design and in SCD inclusion criteria (for details see Table S 2 ). Overall, even if preliminary, these results showed encouraging evidence on the potential effect of NIBS in reducing memory concern s[ 59 ] and in improving long-lasting episodic memory (see Table S 2 ) [ 60 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

“…Despite the lack of evidence on SCD, literature generated over the last years suggests NIBS as a promising technique to maintain cognitive functioning in the aging population; thus, in the next paragraphs, we will provide an overview about the evidence on multi-session interventions, as they can provide the most relevant insights on the NIBS therapeutic effects in improving or maintaining cognitive health (summarized in Table 4 ). While some of these studies showed a lack of benefit after multiple NIBS sessions [ 62 – 66 ], the majority showed positive effects in improving episodic [ 56 , 67 , 68 ] and working [ 57 , 58 , 69 – 72 ] memory in older adults, in some cases with long-lasting effects [ 57 , 58 , 69 ] and associated with significant changes at neural level [ 67 , 72 ]. Across the available literature, the prefrontal cortex represented the most common stimulation target, [ 57 , 58 , 65 , 66 , 68 – 73 ] followed by other frontal [ 56 ] and temporo-parietal regions [ 58 , 62 , 63 , 67 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…While some of these studies showed a lack of benefit after multiple NIBS sessions [ 62 – 66 ], the majority showed positive effects in improving episodic [ 56 , 67 , 68 ] and working [ 57 , 58 , 69 – 72 ] memory in older adults, in some cases with long-lasting effects [ 57 , 58 , 69 ] and associated with significant changes at neural level [ 67 , 72 ]. Across the available literature, the prefrontal cortex represented the most common stimulation target, [ 57 , 58 , 65 , 66 , 68 – 73 ] followed by other frontal [ 56 ] and temporo-parietal regions [ 58 , 62 , 63 , 67 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, NIBS potential should be exploited before the significant neuronal loss has occurred [ 89 ], with a well-characterized sample, a precise definition of the stimulation dose based on individual anatomy [ 90 , 91 ]), and adopting a single-subject approach [ 92 , 93 ]). In addition to this point, the role of individual features, such as demographics (e.g., [ 56 ]) and biological variables [ 70 ], in modulating NIBS efficacy is yet to be explored.…”

Section: Discussionmentioning

confidence: 99%

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Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6

et al. 2021

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Cognitive complaints in the absence of objective cognitive impairment, observed in patients with subjective cognitive decline (SCD), are common in old age. The first step to postpone cognitive decline is to use techniques known to improve cognition, i.e., cognitive enhancement techniques.We aimed to provide clinical recommendations to improve cognitive performance in cognitively unimpaired individuals, by using cognitive, mental, or physical training (CMPT), non-invasive brain stimulations (NIBS), drugs, or nutrients. We made a systematic review of CMPT studies based on the GRADE method rating the strength of evidence.CMPT have clinically relevant effects on cognitive and non-cognitive outcomes. The quality of evidence supporting the improvement of outcomes following a CMPT was high for metamemory; moderate for executive functions, attention, global cognition, and generalization in daily life; and low for objective memory, subjective memory, motivation, mood, and quality of life, as well as a transfer to other cognitive functions. Regarding specific interventions, CMPT based on repeated practice (e.g., video games or mindfulness, but not physical training) improved attention and executive functions significantly, while CMPT based on strategic learning significantly improved objective memory.We found encouraging evidence supporting the potential effect of NIBS in improving memory performance, and reducing the perception of self-perceived memory decline in SCD. Yet, the high heterogeneity of stimulation protocols in the different studies prevent the issuing of clear-cut recommendations for implementation in a clinical setting. No conclusive argument was found to recommend any of the main pharmacological cognitive enhancement drugs (“smart drugs”, acetylcholinesterase inhibitors, memantine, antidepressant) or herbal extracts (Panax ginseng, Gingko biloba, and Bacopa monnieri) in people without cognitive impairment.Altogether, this systematic review provides evidence for CMPT to improve cognition, encouraging results for NIBS although more studies are needed, while it does not support the use of drugs or nutrients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6

et al. 2021

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show abstract

“…The main limitation of this systematic review was the small sample size and low number of neuromodulation interventions; a previous study showed greater positive effects with a multi-session program of tDCS in older adults [45]. Another limitation of this systematic review was the great variability of the stimulation parameters, experimental design and outcome measures used in a small number of published trials.…”

Section: Discussionmentioning

confidence: 96%

Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review

Pino-Esteban

Megía-García

Álvarez

et al. 2021

JCM

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Transcranial direct current stimulation (tDCS) is a non-invasive, easy to administer, well-tolerated, and safe technique capable of affecting brain excitability, both at the cortical and cerebellum levels. However, its effectiveness has not been sufficiently assessed in all population segments or clinical applications. This systematic review aimed at compiling and summarizing the currently available scientific evidence about the effect of tDCS on functionality in older adults over 60 years of age. A search of databases was conducted to find randomized clinical trials that applied tDCS versus sham stimulation in the above-mentioned population. No limits were established in terms of date of publication. A total of 237 trials were found, of which 24 met the inclusion criteria. Finally, nine studies were analyzed, including 260 healthy subjects with average age between 61.0 and 85.8 years. Seven of the nine included studies reported superior improvements in functionality variables following the application of tDCS compared to sham stimulation. Anodal tDCS applied over the motor cortex may be an effective technique for improving balance and posture control in healthy older adults. However, further high-quality randomized controlled trials are required to determine the most effective protocols and to clarify potential benefits for older adults.

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Non-pharmacological interventions for improving language and communication in people with primary progressive aphasia

Roheger,

Riemann,

Brauer

et al. 2024

Cochrane Database of Systematic Reviews

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Multisession transcranial direct current stimulation facilitates verbal learning and memory consolidation in young and older adults

Cited by 33 publications

References 65 publications

Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6

Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6

Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review

Non-pharmacological interventions for improving language and communication in people with primary progressive aphasia

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