Multisensory integration and interactions across vision, hearing, and somatosensation in autism spectrum development and typical development

Dwyer, Patrick; Takarae, Yukari; Zadeh, Iman; Rivera, Susan M.; Saron, Clifford D.

doi:10.1016/j.neuropsychologia.2022.108340

Cited by 6 publications

(1 citation statement)

References 80 publications

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“…Despite the accumulation of behavioral evidence for dysregulation of the sense of touch in autism and its apparent role in foundational features of autism, relatively few studies have examined the neurophysiology of tactile perception in autistic individuals. Some have found comparable electrophysiological responses between autistic and neurotypical groups (Butler et al, 2017; Dwyer et al, 2022; Kadlaskar et al, 2021), while others have shown differentiation in latency (Espenhahn et al, 2021; Hashimoto et al, 1986), hemispheric lateralization (Miyazaki et al, 2007), and response amplitude (Russo et al, 2010). Differences also emerge when the task involves active engagement (Deschrijver et al, 2017; Kemner et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Intact Somatosensory Temporal Sensitivity in Adults on the Autism Spectrum: A High-Density Electrophysiological Mapping Study Using the Mismatch Negativity (MMN) Sensory Memory Paradigm

Isenstein,

Freedman,

Molholm

et al. 2024

Preprint

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Atypical reactivity to somatosensory inputs is common in autism spectrum disorder and carries considerable impact on downstream social communication and quality of life. While behavioral and survey work have established differences in the perception of somatosensory information, little has been done to elucidate the underlying neurophysiological processes that drive these characteristics. Here, we implemented a duration-based somatosensory mismatch negativity paradigm to examine the role of temporal sensitivity and sensory memory in the processing of vibrotactile information in autistic (n=30) and neurotypical (n=30) adults. To capture the variability in responses between groups across a range of duration discrepancies, we compared the electrophysiological responses to frequent standard vibrations (100 ms) and four infrequent deviant vibrations (115, 130, 145, and 160 ms). The same stimuli were used in a follow-up behavioral task to determine active detection of the infrequent vibrations. We found no differences between the two groups with regard to discrimination between standard and deviant vibrations, demonstrating comparable neurologic and behavioral temporal somatosensory perception. However, exploratory analyses yielded subtle differences in amplitude at the N1 and P220 time points. Together, these results indicate that the temporal mechanisms of somatosensory discrimination are conserved in adults on the autism spectrum, though more general somatosensory processing may be affected. We discuss these findings in the broader context of the MMN literature in autism, as well as the potential role of cortical maturity in somatosensory mechanisms.

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Section: Introductionmentioning

confidence: 99%

Intact Somatosensory Temporal Sensitivity in Adults on the Autism Spectrum: A High-Density Electrophysiological Mapping Study Using the Mismatch Negativity (MMN) Sensory Memory Paradigm

Isenstein,

Freedman,

Molholm

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Somatosensory temporal sensitivity in adults on the autism spectrum: A high‐density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm

Isenstein,

Freedman,

Molholm

et al. 2024

Autism Research

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Atypical reactivity to somatosensory inputs is common in autism spectrum disorder and carries considerable impact on downstream social communication and quality of life. While behavioral and survey work have established differences in the perception of somatosensory information, little has been done to elucidate the underlying neurophysiological processes that drive these characteristics. Here, we implemented a duration‐based somatosensory mismatch negativity (MMN) paradigm to examine the role of temporal sensitivity and sensory memory in the processing of vibrotactile information in autistic (n = 30) and neurotypical (n = 30) adults. To capture the variability in responses between groups across a range of duration discrepancies, we compared the electrophysiological responses to frequent standard vibrations (100 ms) and four infrequent deviant vibrations (115, 130, 145, and 160 ms). The same stimuli were used in a follow‐up behavioral task to determine active detection of the infrequent vibrations. We found no differences between the two groups with regard to discrimination between standard and deviant vibrations, demonstrating comparable neurologic and behavioral temporal somatosensory perception. However, exploratory analyses yielded subtle differences in amplitude at the N1 and P220 time points. Together, these results indicate that the temporal mechanisms of somatosensory discrimination are conserved in adults on the autism spectrum, though more general somatosensory processing may be affected. We discuss these findings in the broader context of the MMN literature in autism, as well as the potential role of cortical maturity in somatosensory mechanisms.

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An imbalance of excitation and inhibition in the multisensory cortex impairs the temporal acuity of audiovisual processing and perception

Schormans

Allman

2023

Cerebral Cortex

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The neural integration of closely timed auditory and visual stimuli can offer several behavioral advantages; however, an overly broad window of temporal integration—a phenomenon observed in various neurodevelopmental disorders—could have far-reaching perceptual consequences. Non-invasive studies in humans have suggested that the level of GABAergic inhibition in the multisensory cortex influences the temporal window over which auditory and visual stimuli are bound into a unified percept. Although this suggestion aligns with the theory that an imbalance of cortical excitation and inhibition alters multisensory processing, no prior studies have performed experimental manipulations to determine the causal effects of a reduction of GABAergic inhibition on audiovisual temporal perception. To that end, we used a combination of in vivo electrophysiology, neuropharmacology, and translational behavioral testing in rats to provide the first mechanistic evidence that a reduction of GABAergic inhibition in the audiovisual cortex is sufficient to disrupt unisensory and multisensory processing across the cortical layers, and ultimately impair the temporal acuity of audiovisual perception and its rapid adaptation to recent sensory experience. Looking forward, our findings provide support for using rat models to further investigate the neural mechanisms underlying the audiovisual perceptual alterations observed in neurodevelopmental disorders, such as autism, schizophrenia, and dyslexia.

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Multisensory integration and interactions across vision, hearing, and somatosensation in autism spectrum development and typical development

Cited by 6 publications

References 80 publications

Intact Somatosensory Temporal Sensitivity in Adults on the Autism Spectrum: A High-Density Electrophysiological Mapping Study Using the Mismatch Negativity (MMN) Sensory Memory Paradigm

Intact Somatosensory Temporal Sensitivity in Adults on the Autism Spectrum: A High-Density Electrophysiological Mapping Study Using the Mismatch Negativity (MMN) Sensory Memory Paradigm

Somatosensory temporal sensitivity in adults on the autism spectrum: A high‐density electrophysiological mapping study using the mismatch negativity (MMN) sensory memory paradigm

An imbalance of excitation and inhibition in the multisensory cortex impairs the temporal acuity of audiovisual processing and perception

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