Multiscale real time and high sensitivity ion detection with complementary organic electrochemical transistors amplifier

Romele, Paolo; Gkoupidenis, Paschalis; Koutsouras, Dimitrios A.; Lieberth, Katharina; Kovács-Vajna, Zsolt Miklós; Blom, Paul W. M.; Torricelli, Fabrizio

doi:10.1038/s41467-020-17547-0

Cited by 110 publications

(133 citation statements)

References 59 publications

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“…[107,151] Further work employed complementary OECTs amplifiers with different channel thickness for ion detection, which provided both ion-to-electron transconduction and signal amplification, yielding selective real-time ion (sodium) detection with a sensitivity over 2300 mV −1 V −1 dec −1 and a wide detection range over five orders of magnitude. [152] Recently, further novel OECTs-based biosensor concepts emerged. Braendlein et al combined OECTs in a Wheatstone bridge sensor circuit (Figure 6f) to detect lactate concentration of nonmalignant cells and tumor cells.…”

Section: Channel and Gate Modified Biochemical Oect Sensorsmentioning

confidence: 99%

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Liang

Offenhäusser

Ingebrandt

et al. 2021

Adv Healthcare Materials

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To understand the physiology and pathology of electrogenic cells and the corresponding tissue in their full complexity, the quantitative investigation of the transmission of ions as well as the release of chemical signals is important. Organic (semi-) conducting materials and in particular organic electrochemical transistor are gaining in importance for the investigation of electrophysiological and recently biochemical signals due to their synthetic nature and thus chemical diversity and modifiability, their biocompatible and compliant properties, as well as their mixed electronic and ionic conductivity featuring ion-to-electron conversion. Here, the aim is to summarize recent progress on the development of bioelectronic devices utilizing polymer polyethylenedioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) to interface electronics and biological matter including microelectrode arrays, neural cuff electrodes, organic electrochemical transistors, PEDOT:PSS-based biosensors, and organic electronic ion pumps. Finally, progress in the material development is summarized for the improvement of polymer conductivity, stretchability, higher transistor transconductance, or to extend their field of application such as cation sensing or metabolite recognition. This survey of recent trends in PEDOT:PSS electrophysiological sensors highlights the potential of this multifunctional material to revolve current technology and to enable long-lasting, multichannel polymer probes for simultaneous recordings of electrophysiological and biochemical signals from electrogenic cells.

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Section: Channel and Gate Modified Biochemical Oect Sensorsmentioning

confidence: 99%

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Liang

Offenhäusser

Ingebrandt

et al. 2021

Adv Healthcare Materials

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show abstract

“…This characteristic is promising for detecting small signals in bio‐system applications as shown recently for highly sensitive chemical and biological sensors, brain activity monitoring, and cell function modulation. [ 2,4,5,10–29 ] Indeed the limits of detection for biosensors up to attomolar levels can be achieved by utilizing capacitive coupling between the large 3D capacitance of the channel material and the sensing gate. [ 28 ]…”

Section: Figurementioning

confidence: 99%

“…This characteristic is promising for detecting small signals in bio-system applications as shown recently for highly sensitive chemical and biological sensors, brain activity monitoring, and cell function modulation. [2,4,5,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Indeed the limits of detection for biosensors up to attomolar levels can be achieved by utilizing capacitive coupling between the large 3D capacitance of the channel material and the sensing gate. [28] Because OECT operation must rely on both ionic and charge (electron/hole) transport, balancing/optimizing both processes has proven challenging.…”

mentioning

confidence: 99%

Porous Semiconducting Polymers Enable High‐Performance Electrochemical Transistors

et al. 2021

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Organic polymer electrochemical transistors (OECTs) are of great interest for flexible electronics and bioelectronics applications owing to their high transconductance and low operating voltage. However, efficient OECT operation must delicately balance the seemingly incompatible materials optimizations of redox chemistry, active layer electronic transport, and ion penetration/transport. The latter characteristics are particularly challenging since most high‐mobility semiconducting polymers are hydrophobic, which hinders efficient ion penetration, hence limiting OECT performance. Here, the properties and OECT response of a series of dense and porous semiconducting polymer films are compared, the latter fabricated via a facile breath figure approach. This methodology enables fast ion doping, high transconductance (up to 364 S cm−1), and a low subthreshold swing for the hydrophobic polymers DPPDTT and P3HT, rivalling or exceeding the metrics of the relatively hydrophilic polymer, Pg2T‐T. Furthermore, the porous morphology also enhances the transconductance of hydrophilic polymers, offering a general strategy for fabricating high‐performance electrochemical transistors.

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Section: High-sensitive Ion Detection At Low Voltages With Current-driven Oectsmentioning

confidence: 99%

Current‐Driven Organic Electrochemical Transistors for Monitoring Cell Layer Integrity with Enhanced Sensitivity

Lieberth

Romele

Torricelli

et al. 2021

Adv Healthcare Materials

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In this progress report an overview is given on the use of the organic electrochemical transistor (OECT) as a biosensor for impedance sensing of cell layers. The transient OECT current can be used to detect changes in the impedance of the cell layer, as shown by Jimison et al. To circumvent the application of a high gate bias and preventing electrolysis of the electrolyte, in case of small impedance variations, an alternative measuring technique based on an OECT in a current-driven configuration is developed. The ion-sensitivity is larger than 1200 mV V -1 dec -1 at low operating voltage. It can be even further enhanced using an OECT based complementary amplifier, which consists of a p-type and an n-type OECT connected in series, as known from digital electronics. The monitoring of cell layer integrity and irreversible disruption of barrier function with the current-driven OECT is demonstrated for an epithelial Caco-2 cell layer, showing the enhanced ion-sensitivity as compared to the standard OECT configuration. As a state-of-the-art application of the current-driven OECT, the in situ monitoring of reversible tight junction modulation under the effect of drug additives, like poly-l-lysine, is discussed. This shows its potential for in vitro and even in vivo toxicological and drug delivery studies.

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Multiscale real time and high sensitivity ion detection with complementary organic electrochemical transistors amplifier

Cited by 110 publications

References 59 publications

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

PEDOT:PSS‐Based Bioelectronic Devices for Recording and Modulation of Electrophysiological and Biochemical Cell Signals

Porous Semiconducting Polymers Enable High‐Performance Electrochemical Transistors

Current‐Driven Organic Electrochemical Transistors for Monitoring Cell Layer Integrity with Enhanced Sensitivity

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