Multiscale modelling via split-step methods in neural firing

Abstract

Neuronal models based on the Hodgkin-Huxley equation form a fundamental framework in the field of computational neuroscience. While the neuronal state is often modelled deterministically, experimental recordings show stochastic fluctuations, presumably driven by molecular noise from the underlying microphysical conditions. In turn, the firing of individual neurons gives rise to an electric field in extracellular space, also thought to affect the firing pattern of nearby neurons.We develop a multiscale model which combines a stochastic ion channel gating process taking place on the neuronal membrane, together with the propagation of an action potential along the neuronal structure. We also devise a numerical method relying on a split-step strategy which effectively couples these two processes and we experimentally test the feasibility of this approach. We finally also explain how the approach can be extended with Maxwell's equations to allow the potential to be propagated in extracellular space. ARTICLE HISTORY

Multiscale Stochastic Neuron Modeling - With Applications In Deep Brain Stimulation (WIP)

“…Only the gating state m 3 h 1 represents an open ion channel, for all other states the ion channel is closed. Adapted from[8].…”