Multiscale modeling of skin mechanical Behavior: Effect of dehydrating agent on Collagen’s mechanical properties

Verma, Nitu; Sharma, Paramveer; Jayabal, Hemalatha; Dingari, Naga Neehar; Gupta, Rakesh; Rai, Beena

doi:10.1016/j.jbiomech.2022.111361

“…Using these principles, researchers have modelled the nonlinear mechanics of single collagen molecule (Buehler and Wong 2007), collection of molecules (A. Gautieri, et al 2011) collagen molecules in the presence of water (Depalle, et al 2015) and in the presence of dehydrating agent (Verma, et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Modelling the Mechanical Behavior of Collagenous Materials by Considering Multiscale Effects

Dingari,

Sharma,

Rizvi

et al. 2024

Preprint

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Collagen is an important component of many biological tissues and plays a key role in the physiological functions of the tissue. The mechanical properties of biological tissues are important for many medical and pharmaceutical applications. For instance, to probe the interaction between a medical device and a tissue it becomes important to study the stress and deformation within the tissue under external load. Modelling the mechanics of collagenous tissues is non-trivial because of the anisotropic and hyperelastic nature of the tissue. The arrangement of the collagen within the tissue governs the directional dependence of its mechanical properties. Further, collagen mechanics is itself a strong function of the arrangement of various collagenous components (tropocollagen molecules, fibrils, fibers) at various length scales. Therefore to accurately model the mechanics of a collagenous tissue at macroscopic length scale it is necessary to consider the multiscale mechanics of collagen. In this work, we develop a multiscale-informed finite element method (multi-FEM) framework to model the mechanics of a collagenous tissue. We propose a novel exponential strain energy density function for the mechanics of collagen fibers, which shows excellent agreement with the strain energy density of a collagen fiber obtained by considering multiscale effects (molecule to fiber). Further, this exponential strain energy density is used to simulate the macroscopic mechanics of the tissue using finite element method. Using this multi-FEM framework, we systematically investigate the influence of various lower-length scale collagen properties on the macroscopic stress response of the collagenous tissue. This framework can be very useful in the development of high-fidelity computational models of collagenous tissues that can include the huge variability in the tissue properties.

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“…At the molecular scale, molecular dynamics is a commonly used technique to account for the influence of short-range interaction forces such as covalent bonds, electrostatic interactions and van der Waals forces on the mechanics . Using these principles, researchers have modelled the nonlinear mechanics of single collagen molecule [22], collection of molecules [23] collagen molecules in the presence of water [24] [25] and in the presence of dehydrating agent [26].…”

Section: Introductionmentioning

confidence: 99%

Modelling the Mechanical Behavior of Collagenous Materials by Considering Multiscale Effects

Dingari,

Sharma,

Rizvi

et al. 2024

Preprint

Self Cite

0

View full text Add to dashboard Cite

Collagen is an important component of many biological tissues and plays a key role in the physiological functions of the tissue. The mechanical properties of biological tissues are important for many medical and pharmaceutical applications. For instance, to probe the interaction between a medical device and a tissue it becomes important to study the stress and deformation within the tissue under external load. Modelling the mechanics of collagenous tissues is non-trivial because of the anisotropic and hyperelastic nature of the tissue. The arrangement of the collagen within the tissue governs the directional dependence of its mechanical properties. Further, collagen mechanics is itself a strong function of the arrangement of various collagenous components (tropocollagen molecules, fibrils, fibers) at various length scales. Therefore to accurately model the mechanics of a collagenous tissue at macroscopic length scale it is necessary to consider the multiscale mechanics of collagen. In this work, we develop a multiscale-informed finite element method (multi-FEM) framework to model the mechanics of a collagenous tissue. We propose a novel exponential strain energy density function for the mechanics of collagen fibers, which shows excellent agreement with the strain energy density of a collagen fiber obtained by considering multiscale effects (molecule to fiber). Further, this exponential strain energy density is used to simulate the macroscopic mechanics of the tissue using finite element method. Using this multi-FEM framework, we systematically investigate the influence of various lower-length scale collagen properties on the macroscopic stress response of the collagenous tissue. This framework can be very useful in the development of high-fidelity computational models of collagenous tissues that can include the huge variability in the tissue properties.

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On the role of water in regulating the mechanics of collagen fibers

Long,

Peng,

Li

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Multiscale modeling of skin mechanical Behavior: Effect of dehydrating agent on Collagen’s mechanical properties

Cited by 6 publications

References 33 publications

Modelling the Mechanical Behavior of Collagenous Materials by Considering Multiscale Effects

Modelling the Mechanical Behavior of Collagenous Materials by Considering Multiscale Effects

Modelling the Mechanical Behavior of Collagenous Materials by Considering Multiscale Effects

On the role of water in regulating the mechanics of collagen fibers

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