Multiscale modeling of bone tissue mechanobiology

García-Aznar, J.M.; Nasello, Gabriele; Hervas-Raluy, Silvia; Pérez, M.Á.; Gómez‐Benito, María José

doi:10.1016/j.bone.2021.116032

Cited by 32 publications

(14 citation statements)

References 139 publications

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“…Mechanobiology research in BTE aims at getting insight into how the scaffolds or the application of mechanical loads affect the development of tissue-engineered bone tissue, which is intended to be used for bone disease research, drug testing, etc. (García-Aznar et al, 2021;Kim et al, 2021). In vitro mechanobiology includes the creation of either static or dynamic micro-mechanical environments.…”

Section: Introductionmentioning

confidence: 99%

“…With improvements in 3D printing/additive manufacturing technology, scaffolds with well-defined geometries can be manufactured, and this will probably be the standard for scaffold manufacturing in the near future (Bahraminasab, 2020). To investigate the influence of scaffold pore geometry on the internal micro-mechanical environment, computational approaches are commonly used, thanks to the capability of such approaches to calculate/ simulate the mechanical environment at the micro (or even sub-micro) scale with low cost, which is challenging for experimental measurements (García-Aznar et al, 2021). It has been found that the scaffolds' pore geometry can largely influence the micro-mechanical environment within the scaffolds (Olivares et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Zhao

Xiong

Ito

et al. 2021

Front. Bioeng. Biotechnol.

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Mechanobiology research is for understanding the role of mechanics in cell physiology and pathology. It will have implications for studying bone physiology and pathology and to guide the strategy for regenerating both the structural and functional features of bone. Mechanobiological studies in vitro apply a dynamic micro-mechanical environment to cells via bioreactors. Porous scaffolds are commonly used for housing the cells in a three-dimensional (3D) culturing environment. Such scaffolds usually have different pore geometries (e.g. with different pore shapes, pore dimensions and porosities). These pore geometries can affect the internal micro-mechanical environment that the cells experience when loaded in the bioreactor. Therefore, to adjust the applied micro-mechanical environment on cells, researchers can tune either the applied load and/or the design of the scaffold pore geometries. This review will provide information on how the micro-mechanical environment (e.g. fluid-induced wall shear stress and mechanical strain) is affected by various scaffold pore geometries within different bioreactors. It shall allow researchers to estimate/quantify the micro-mechanical environment according to the already known pore geometry information, or to find a suitable pore geometry according to the desirable micro-mechanical environment to be applied. Finally, as future work, artificial intelligent – assisted techniques, which can achieve an automatic design of solid porous scaffold geometry for tuning/optimising the micro-mechanical environment are suggested.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Zhao

Xiong

Ito

et al. 2021

Front. Bioeng. Biotechnol.

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“…Finally, if coupled with mechanobiological models, predictions of long-term bone healing and remodelling could be obtained. To date, most of the bone fracture healing and remodelling algorithms are based on stress or strain-based mechanical stimulus (García-Aznar et al, 2021) and generally assume a linear elastic mechanical behaviour (Sandino and Lacroix, 2011; Schulte et al, 2011; Verbruggen et al, 2012). Here, it has been shown that even at small deformations, local tissue damage may occur.…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, biomechanical stability needs to appropriately withstand physiological loads which enables early mobilisation without additional risk of fracture, delayed repair and/or non-union formation (Augat et al, 2021). On the other hand, bone healing is a mechano-regulated process where tissue undergoes continued differentiation according to the sensed mechanical stimuli (García-Aznar et al, 2021; Huiskes et al, 1997; Lacroix and Prendergast, 2002). Therefore, the mechanical environment in and around the defect site during healing must provide adequate mechanobiological cues without damaging bone during the healing process.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone

Fernández

Sasso

McPhee

et al. 2022

Preprint

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Bone regeneration in critical-sized defects is a clinical challenge, with biomaterials under constant development aiming at enhancing the natural bone healing process. The delivery of bone morphogenetic proteins (BMPs) in appropriate carriers represents a promising strategy for bone defect treatment but optimisation of the spatial-temporal release is still needed for the regeneration of bone with biological, structural, and mechanical properties comparable to the native tissue. Nonlinear micro finite element (μFE) models can address some of these challenges by providing a tool able to predict the biomechanical strength and microdamage onset in newly formed bone when subjected to physiological or supraphysiological loads. Yet, these models need to be validated against experimental data. In this study, experimental local displacements in newly formed bone induced by osteoinductive biomaterials subjected to in situ X-ray computed tomography compression in the apparent elastic regime and measured using digital volume correlation (DVC) were used to validate μFE models. Displacement predictions from homogeneous linear μFE models were highly correlated to DVC-measured local displacements, while tissue heterogeneity capturing mineralisation differences showed negligible effects. Nonlinear μFE models improved the correlation and showed that tissue microdamage occurs at low apparent strains. Microdamage seemed to occur next to large cavities or in biomaterial-induced thin trabeculae, independent of the mineralisation. While localisation of plastic strain accumulation was similar, the amount of damage accumulated in these locations was slightly higher when including material heterogeneity. These results demonstrate the ability of the nonlinear μFE model to capture local microdamage in newly formed bone tissue and can be exploited to improve the current understanding of healing bone and mechanical competence. This will ultimately aid the development of BMPs delivery systems for bone defect treatment able to regenerate bone with optimal biological, mechanical, and structural properties.

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“…Macro forces acting on the tissue, such as strain, pressure, stability, and fluid velocity are known to have a mechanical effect on the individual cell matrix, affecting their function, migration, and differentiation, but the interrelation remains poorly understood. Other works on both experimental and computational modelling of bone healing can be found in the literature [37][38][39].…”

Section: Mechanical Effects On Bone Development and Healingmentioning

confidence: 99%

Tuning the Cell and Biological Tissue Environment through Magneto-Active Materials

et al. 2021

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This review focuses on novel applications based on multifunctional materials to actuate biological processes. The first section of the work revisits the current knowledge on mechanically dependent biological processes across several scales from subcellular and cellular level to the cell-collective scale (continuum approaches). This analysis presents a wide variety of mechanically dependent biological processes on nervous system behaviour; bone development and healing; collective cell migration. In the second section, this review presents recent advances in smart materials suitable for use as cell substrates or scaffolds, with a special focus on magneto-active polymers (MAPs). Throughout the manuscript, both experimental and computational methodologies applied to the different treated topics are reviewed. Finally, the use of smart polymeric materials in bioengineering applications is discussed.

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Multiscale modeling of bone tissue mechanobiology

Cited by 32 publications

References 139 publications

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering

Nonlinear micro finite element models based on digital volume correlation measurements predict early microdamage in newly formed bone

Tuning the Cell and Biological Tissue Environment through Magneto-Active Materials

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