Multiscale imaging of bone microdamage

Poundarik, Atharva A.; Vashishth, Deepak

doi:10.3109/03008207.2015.1008133

Cited by 29 publications

(23 citation statements)

References 81 publications

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“…Current standards for diffuse damage analysis rely on methods such as scanning electron microscopy because of the submicron scale at which it occurs. (40) Additionally, there are currently no methods for evaluating cortical microdamage of any kind in vivo, but developing methods will likely detect the larger linear microcracks prior to diffuse damage due to similar issues of resolution.…”

Section: What Is Bone Microdamage and Why Does It Occur?mentioning

confidence: 99%

“…On a practical level, linear microcracks are the easiest type of cortical microdamage to assess, as they are principally examined via two‐dimensional (2D) methods requiring at minimum staining capabilities and access to light microscopy. Current standards for diffuse damage analysis rely on methods such as scanning electron microscopy because of the submicron scale at which it occurs . Additionally, there are currently no methods for evaluating cortical microdamage of any kind in vivo, but developing methods will likely detect the larger linear microcracks prior to diffuse damage due to similar issues of resolution.…”

Section: Introductionmentioning

confidence: 99%

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Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Dominguez

Agnew

2019

JBMR Plus

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Microdamage is a component of bone quality believed to play an integral role in bone health. However, comparability between existing studies is fraught with issues due to highly variable methods of sample preparation and poorly defined quantification criteria. To address these issues, this article has two aims. First, detailed methods for preparation and analysis of linear microcracks in human ribs, specifically addressing troubleshooting issues cited in previous studies, are laid out. Second, new, partially validated criteria are proposed in an effort to reduce subjective differences in microcrack counts and measures, ensuring more comparable results between studies. Revised definitions based on current literature in conjunction with a digital atlas to reduce observer inaccuracy and bias are presented. The goal is to provide a practical methodology for bone biologists and biomechanists to collect and analyze linear microcracks for basic science research. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Section: What Is Bone Microdamage and Why Does It Occur?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Dominguez

Agnew

2019

JBMR Plus

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“…Readers interested in more information of biomedical QMI in general might reference recent reviews of multiscale imaging. [240][241][242][243][244] 4 Data Analysis Challenges…”

Section: Quantitative Multiscale Imaging Outside the Breastmentioning

confidence: 99%

Review of quantitative multiscale imaging of breast cancer

et al. 2018

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Breast cancer is the most common cancer among women worldwide and ranks second in terms of overall cancer deaths. One of the difficulties associated with treating breast cancer is that it is a heterogeneous disease with variations in benign and pathologic tissue composition, which contributes to disease development, progression, and treatment response. Many of these phenotypes are uncharacterized and their presence is difficult to detect, in part due to the sparsity of methods to correlate information between the cellular microscale and the whole-breast macroscale. Quantitative multiscale imaging of the breast is an emerging field concerned with the development of imaging technology that can characterize anatomic, functional, and molecular information across different resolutions and fields of view. It involves a diverse collection of imaging modalities, which touch large sections of the breast imaging research community. Prospective studies have shown promising results, but there are several challenges, ranging from basic physics and engineering to data processing and quantification, that must be met to bring the field to maturity. This paper presents some of the challenges that investigators face, reviews currently used multiscale imaging methods for preclinical imaging, and discusses the potential of these methods for clinical breast imaging.

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“…While cracks propagate within the 3D bone structure, only a few observation techniques are available to quantify their morphology in 3D (Poundarik and Vashishth, 2015). The first observation of micro cracks in 3D were obtained with microscopic imaging after serial sectioning (Mohsin et al, 2006) or confocal microscopy (Zarrinkalam et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Influence of loading condition and anatomical location on human cortical bone linear micro-cracks

Gauthier

Langer

Follet

et al. 2019

Journal of Biomechanics

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Human cortical bone fracture toughness depends on the anatomical locations under quasistatic loading. Recent results also showed that under fall-like loading, cortical bone fracture toughness is similar at different anatomical locations in the same donor. While cortical bone toughening mechanisms are known to be dependent on the tissue architecture under quasi-static loading, the fracture mechanisms during a fall are less studied. In the current study, the structural parameters of eight paired femoral diaphyses, femoral necks and radial diaphyses were mechanically tested under quasi-static and fall-like loading conditions (female donors, 70 ± 14 y.o., [50 -91 y.o.]). Synchrotron radiation micro-CT imaging was used to quantify the amount of micro-cracks formed during loading.The volume fraction of these micro-cracks was significantly higher within the specimens loaded under a quasi-static condition than under a loading representative of a fall. Under fall-like loading, there was no difference in crack volume fraction between the different paired anatomical locations. This result shows that the micro-cracking toughening mechanism depends both on the anatomical location and on the loading condition.

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Multiscale imaging of bone microdamage

Cited by 29 publications

References 81 publications

Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Review of quantitative multiscale imaging of breast cancer

Influence of loading condition and anatomical location on human cortical bone linear micro-cracks

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