Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

Sun, Xinghuai; Zhang, Xiaochuan; Ren, Xiuyan; Sun, Hongyu; Wu, Li; Wang, Caifen; Ye, Xiaohui; York, Peter; Gao, Zhaobing; Jiang, Hualiang; Zhang, Jiwen

doi:10.1002/advs.202003941

Cited by 9 publications

(13 citation statements)

References 39 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 21,22 ] A cyclodextrin metal‐organic skeleton (CD‐MOF) was formed using cyclodextrin (CD) as an organic ligand and potassium ions as inorganic coordination ions. [ 23,24 ] Using the biocompatible CD‐MOF as the template and the tiny space in CD‐MOF to restrict the growth of silver nanoparticles, a CD‐MOF (Ag@MOF) loaded with ultrafine silver nanoparticles was synthesized, which could achieve higher antibacterial activity. [ 25,26 ]…”

Section: Introductionmentioning

confidence: 99%

Injectable Antibacterial Hydrogel with Asiaticoside‐Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn‐Infected Wounds

Feng

Liu²,

Chen

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Post‐injury infection and wound healing are recurrent daily life problems. Therefore, the necessity of developing a biomaterial with antibacterial and wound‐healing properties is paramount. Based on the special porous structure of hydrogel, this work modifies recombinant collagen and quaternary ammonium chitosan and fused them with silver nanoparticles (Ag@mental‐organic framework (Ag@MOF)) with antibacterial properties, and asiaticoside‐loaded liposomes (Lip@AS) with anti‐inflammatory/vascularization effects to form the rColMA/QCSG/LIP@AS/Ag@MOF (RQLAg) hydrogel. The prepared hydrogel possesses good sustainable release capabilities of Ag+ and AS and exhibits concentration‐dependent swelling properties, pore size, and compressive strength. Cellular experiments show that the hydrogel exhibit good cell compatibility and promote cell migration, angiogenesis, and M1 macrophage polarization. Additionally, the hydrogels exhibit excellent antibacterial activity against Escherichia coli and Staphylococcus aureus in vitro. In vivo, Sprague Dawley rats burn‐wound infection model showed that the RQLAg hydrogel could efficiently promote wound healing and has stronger healing promoting abilities than those of Aquacel Ag. In summary, the RQLAg hydrogel is expected to be an excellent material for accelerating open wound healing and preventing bacterial infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Injectable Antibacterial Hydrogel with Asiaticoside‐Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn‐Infected Wounds

Feng

Liu²,

Chen

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Seminal 3D printing efforts in the field have been largely limited to depositing monolayer sheets reminiscent of transwell inserts [117]. Whether future solutions will revolve around advanced 3D printing techniques to recapitulate acinar designs in vitro, a space-filling topology becomes most relevant when attempting to bridge the gap with the anticipated inhaled aerosol dose deposited on the 3D airway lumen [36,86,118]. This latter point holds direct ties with the transport and fate of inhaled aerosols in the lungs (see discussion in section 3.4).…”

Section: The 3d Pulmonary Acinar Morphologymentioning

confidence: 99%

“…As these transport mechanisms operate within an intricate 3D airway network covering a breadth of length scales within a space-filling volume, combined with a wide range of gravitational orientations (e.g. apical vs. basal lung lobes), PM deposition patterns in the deep lungs are known to be complex and spatially heterogeneous [35,118,136,142]. Here, microfluidic acinar airway models have enabled seminal quantitative in vitro studies of aerosol (PM) deposition patterns under physiological breathing conditions providing for the first time, temporally-resolved tracking of airborne particle flight within alveolar cavities [143].…”

Section: Physiological Respiratory Airflows and Inhaled Aerosol Transportmentioning

confidence: 99%

Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics

Artzy‐Schnirman

Raviv

Flikshtain

et al. 2021

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Over the past years, advanced in vitro pulmonary platforms have witnessed exciting developments that are pushing beyond traditional preclinical cell culture methods. Here, we discuss ongoing efforts in bridging the gap between in vivo and in vitro interfaces and identify some of the bioengineering challenges that lie ahead in delivering new generations of human-relevant in vitro pulmonary platforms. Notably, in vitro strategies using foremost lung-on-chips and biocompatible "soft" membranes have focused on platforms that emphasize phenotypical endpoints recapitulating key physiological and cellular functions. We review some of the most recent in vitro studies underlining seminal therapeutic screens and translational applications and open our discussion to promising avenues of pulmonary therapeutic exploration focusing on liposomes. Undeniably, there still remains a recognized trade-off between the physiological and biological complexity of these novel in vitro lung models and their ability to deliver assays with throughput capabilities. The upcoming years are thus anticipated to see further developments in broadening the applicability of such in vitro systems and accelerating therapeutic exploration for drug discovery and translational medicine in treating respiratory disorders.

show abstract

Section: Evaluation Of Structure-oriented Ddssmentioning

confidence: 99%

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Xue

et al. 2023

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and biological properties of APIs and excipients have been extensively studied for their contribution to DDS quality and effectiveness; however, the structural characteristics of DDSs have not been adequately explored. Structure pharmaceutics involves the study of the structure of DDSs, especially the three-dimensional (3D) structures, and its interaction with the physiological and pathological structure of organisms, possibly influencing their release kinetics and targeting abilities. A systematic overview of the structures of a variety of dosage forms, such as tablets, granules, pellets, microspheres, powders, and nanoparticles, is presented. Moreover, the influence of structures on the release and targeting capability of DDSs has also been discussed, especially the in vitro and in vivo release correlation and the structure-based organ- and tumor-targeting capabilities of particles with different structures. Additionally, an in-depth discussion is provided regarding the application of structural strategies in the DDSs design and evaluation. Furthermore, some of the most frequently used characterization techniques in structure pharmaceutics are briefly described along with their potential future applications.

show abstract

Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

Cited by 9 publications

References 39 publications

Injectable Antibacterial Hydrogel with Asiaticoside‐Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn‐Infected Wounds

Injectable Antibacterial Hydrogel with Asiaticoside‐Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn‐Infected Wounds

Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Contact Info

Product

Resources

About