Multiresponse Strategies To Modulate Burst Degradation and Release from Nanoparticles

Abstract

Logic gate nanoparticles, where two chemical transformations take place one after the other, were successfully formulated from a newly synthesized random co-polymer. This polymer, poly([2,2′-(propane-2,2-diylbis(oxy))bis(ethane-2,1-diyl) diacrylate ]-co-[hexane-1,6-diyl diacrylate]-4,4′ trimethylene dipiperidine), (poly-β-aminoester ketal-2) contains two pH responsive moieties within its backbone. As nanoparticles they function akin to an AND logic gate. The β-aminoester backbone moiety provides a pH triggered solubility switch, only when this switch is “ON” does the ketal moiety also turn “ON” to undergo rapid acid catalyzed hydrolysis. These AND logic gate polymeric nanoparticles were prepared using an oil in water emulsion method. Their degradation in the pH range of 7.4−5 was monitored by dynamic light scattering and showed excellent stability at pH 7.4 and rapid degradation at pH 5. Our results indicate that the prepared logic gate nanoparticles may prove valuable in delivering therapeutics and diagnostics to cells and diseased tissue.

Physical and Chemical Strategies for Therapeutic Delivery by Using Polymeric Nanoparticles

“…On the other hand, in vivo distribution of 150-nm particles having a -potential of ϳϪ15 mV showed more efficient accumulation at the tumor site compared with more negative or positive particles or bigger particles . Because cationic particles can improve their uptake but cause undesired interaction with any cell type (Dellian et al, 2000), negatively charged particles with longer circulation half-lives may be designed to switch to positively charged ones at the site of action (Sankaranarayanan et al, 2010).…”

Physical and Biophysical Characteristics of Nanoparticles: Potential Impact on Targeted Drug Delivery

“…Cationic NPs show improved cellular uptake but cause nonspecifi c interactions in vivo [ 46 ]. It would be ideal to design NPs that at fi rst would carry a negative or neutral surface charge for a longer circulation half-life but which could then reverse their surface charge to cationic at the site of action to facilitate uptake of NPs into the targeted cell [ 47 ]. Understanding the effects of even one physical parameter on biodistribution is quite complex because that parameter also simultaneously changes other characteristics of NPs.…”

Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores

“…proteins, enzymes, catalytic metal nanoparticles), 45,173 by electrostatic interactions of e.g. small molecules with the polymeric matrix [137][138] or by embedding compounds into collapsed networks, 282 thus excluding water from the gel interior and preventing diffusion. for small molecules embedded in the network, the protonation of the anionic groups of the network forming copolymer upon lowering the pH reduces the electrostatic interactions between the positively charged payload and the network.…”