Multiresistant Invasive Escherichia Coli Infection in South London

Wright, Edward; Perinpanayagam, R.M.

doi:10.1016/s0140-6736(87)90190-5

Cited by 9 publications

(7 citation statements)

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“…This E. coli serotype caused 29 cases of septicaemia during the outbreak, while it had caused only 16/674 septicaemia cases over the previous 17 years [13]. Following this reported outbreak in West Lambeth, similar findings were documented in Roehampton [25] and South London [26]. In addition, a study in Barcelona, Spain found the epidemic strain in 1 .…”

Section: Expec Outbreakssupporting

confidence: 64%

A systematic review of outbreak and non-outbreak studies of extraintestinal pathogenicEscherichia colicausing community-acquired infections

George

Manges

2010

Epidemiol. Infect.

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A systematic review of outbreak and non-outbreak studies of infections caused by extraintestinal pathogenic Escherichia coli (ExPEC) was conducted. This review examines the epidemiology, seasonality, source or mode of transmission, and temporal changes, based on E. coli serogroup, in ExPEC causing sporadic vs. outbreak-associated infections. Twelve outbreak and 28 non-outbreak studies were identified. The existence of ExPEC outbreaks was well supported. Three of four outbreak reports indicated peak periods during the winter months. Serogroups associated with outbreak infections ranged from 1% to 26% (average 11·4%) vs. (range 1-15%, average 3·5%) for serogroups associated with sporadic infections; the distribution of serogroups also differed for outbreak and non-outbreak infections. Study authors indicated that the outbreaks may have resulted from foodborne transmission, but direct evidence was unavailable. This review provides evidence that the epidemiology of endemic vs. epidemic ExPEC infections differs; however, study reporting quality limited epidemiological inferences.

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Section: Expec Outbreakssupporting

confidence: 64%

A systematic review of outbreak and non-outbreak studies of extraintestinal pathogenicEscherichia colicausing community-acquired infections

George

Manges

2010

Epidemiol. Infect.

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“…This was one of the first recognized community-setting outbreaks of ExPEC infections, which mostly included UTI, but also cases of BSI, meningitis, and endocarditis. During the same period, several hospitals in London reported an increased prevalence of bacteraemia caused by serogroup O15 [18][19][20]. Prior to this period, serotype O15:K52:H1 was uncommon in London.…”

Section: St393 E Coli O15:k52:h1mentioning

confidence: 99%

Pandemic lineages of extraintestinal pathogenic Escherichia coli

Riley

2014

Clinical Microbiology and Infection

339

282

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Pathogenic Escherichia coli strains cause a wide variety of intestinal and extraintestinal infections. The widespread geographical clonal dissemination of intestinal pathogenic E. coli strains, such as E. coli O157:H7, is well recognized, and its spread is most often attributed to contaminated food products. On the other hand, the clonal dissemination of extraintestinal pathogenic E. coli (ExPEC) strains is also recognized, but the mechanism of their spread is not well explained. Here, I describe major pandemic clonal lineages of ExPEC based on multilocus sequence typing (MLST), and discuss possible reasons for their global dissemination. These lineages include sequence type (ST)131, ST393, ST69, ST95, and ST73, which are all associated with both community-onset and healthcare-associated infections, in particular urinary tract infections and bloodstream infections. As with many other types of drug-resistant Gram-negative and Gram-positive bacterial infections, drug-resistant ExPEC infections are recognized to be caused by a limited set of clonal lineages. However, reported observations on these major pandemic lineages suggest that the resistance phenotype is not necessarily the determinant of their clonal dissemination. Both epidemiological factors and their intrinsic biological 'fitness' are likely to contribute. An important public health and clinical concern is that pandemicity itself may be a determinant of progressive drug resistance acquisition by clonal lineages. New research is urgently needed to better understand the epidemiological and biological causes of ExPEC pandemicity.

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“…All isolates were identified by standard biochemical tests3 or by API 20E (API-bioMerieux, Basingstoke). 0serogrouping was done as described previously4 with antisera against 14 of the most common 0-serogroups (1,2,4,5,7,8,9,11,15,17,18,25,75). Antibioticsensitivities were determined by the Stokes method on DST agar (Oxoid; CM 261) with Oxoid disks containing (pg) ampicillin 10, chloramphenicol 10, streptomycin 10, sulphamethoxazole 25, tetracycline 10 and trimethoprim 1.25 and with E. coli NCTC 10418 as control; isolates resistant to all six antibiotics will be referred to as 'multiresistant'.…”

Section: Characterisation Of Bacteriamentioning

confidence: 99%

The rise and fall of Escherichia coli O 15 in a London Teaching Hospital

O'Neill

Talboys²,

Roberts³

et al. 1990

Journal of Medical Microbiology

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A marked increase in the prevalence of bacteraemia due to Escherichia coli of serogroup O15 was noted during November and December 1986 at Charing Cross Hospital. This multiresistant strain had been reported by several hospitals in south London. All isolates of E. coli from patients with bacteraemia between October 1986 and the end of September 1988 were assessed for the presence of the O15 antigen and for the unusual pattern of resistance to six antimicrobial agents. As a guide to faecal carriage, isolates from urine were similarly assessed during seven 4-week periods between January 1987 and June 1988. Of the 123 E. coli isolates from blood, 25 (20%) were serogroup O15 and 20 of these expressed the same pattern of multiresistance; 17 of these multiresistant isolates occurred in the 4-month period 1 Nov. 1986-28 Feb. 1987. During the remaining 19 months of the study only eight isolates were serogroup O15 of which only three were multiresistant. In the first 4-week period that urine isolates were studied 21 Jan. 1987-17 Feb. 1987, 26 (13.2%) of the 195 isolates were serogroup O15 of which 20 were multiresistant. The proportion of serogroup O15 isolates fell gradually until, in June 1988, the last period studied, only 8 (4.2%) of the 189 isolates were serogroup O15, of which only one was multiresistant. In a preliminary study of plasmids in six serogroup O15 isolates from blood, three multiresistant isolates and one that was sensitive to chloramphenicol appeared to carry a similar plasmid of c. 100 Mda.(ABSTRACT TRUNCATED AT 250 WORDS)

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Multiresistant Invasive Escherichia Coli Infection in South London

Cited by 9 publications

References 0 publications

A systematic review of outbreak and non-outbreak studies of extraintestinal pathogenicEscherichia colicausing community-acquired infections

A systematic review of outbreak and non-outbreak studies of extraintestinal pathogenicEscherichia colicausing community-acquired infections

Pandemic lineages of extraintestinal pathogenic Escherichia coli

The rise and fall of Escherichia coli O 15 in a London Teaching Hospital

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