Multiresistant Gram-negative infections: a global perspective

Ho, Jennifer; Tambyah, Paul A; Paterson, David L.

doi:10.1097/qco.0b013e32833f0d3e

Cited by 162 publications

(123 citation statements)

References 110 publications

(105 reference statements)

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“…Reports in the United States and Europe point out the major problem caused by enteric bacteria with metallo-beta-lactamase (MBL) and KPC related carbapenem resistance [1,[3][4][5][6]. The emergence and the spread of acquired carbapenem-hydrolysing class D beta-lactamases (CHDLs) have been well documented worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…In Enterobacteriaceae, carbapenemases are diverse problem; these belong to molecular class B (IMP, VIM or NDM), class A (KPC) and class D (OXA-23 and OXA-48) enzymes as well as those combining AmpC enzyme or an extended-spectrum β-lactamase (ESBL) with porin loss. These carbapenemases are involved in outbreaks in various geographical regions and are increasingly reported in sporadic cases worldwide [1][2][3][4][5][6]. OXA carbapenemases are responsible for middle level carbapenem resistance mostly among Acinetobacter spp.…”

Section: Introductionmentioning

confidence: 99%

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Detection of OXA-51 Carbapenemase Gene in Klebsiella pneumoniae: A Case Report and a New Dimension on Carbapenemase Resistance

Budak¹,

AktaÅ²,

Öncül³

et al. 2013

J Mol Genet Med

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We investigated the occurence of genes associated with the production of carbapenem hydrolysing carbapenemases in Klebsiella pneumoniae isolates recovered from ICU patient. Antimicrobial susceptibility testing was performed and resistance genes were characterized by PCR amplification and sequencing. The Modified Hodge Test (MHT), MBL E-test, EDTA and aminophenylboronic acid (APBA) combined disk diffusion method, and a disk enzymatic assay were performed for the screening of carbapenemases. MICs of carbapenems were as follows (mg/L) ertapenem 8, meropenem 1, imipenem 0.25 and doripenem 0.5. The isolate demonstrated positive results in the ESBL, EDTA and APBA combined tests, and disk enzymatic assay. PCR and sequencing revealed the presence of bla OXA-51 and bla CTX-M-15 beta-lactamase genes. Plasmids were not transferred to recipient E.coli by conjugation and transformation. In conclusion, we report on the first detection of the OXA-51 harboring K.pneumoniae isolate and co-produced a CTX-M-15 β-lactamase.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of OXA-51 Carbapenemase Gene in Klebsiella pneumoniae: A Case Report and a New Dimension on Carbapenemase Resistance

Budak¹,

AktaÅ²,

Öncül³

et al. 2013

J Mol Genet Med

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“…Treatment of infections caused by resistant strains is growing public health problem, primarily due to limited choice of effective antimicrobial agents and absence of effective therapy 15 . Ability of this bacterial spe-Осетљивост сојева Klebsiella pneumoniae изолованих из воде за пиће и површинских вода на aнtибиотике 3 ствени проблем, пре свега због суженог избо-ра ефикасних антимикробних лекова па чак и одсуства делотворне терапије 15 . Способност ове бактеријске врсте да се брзо шири у бол-ничкој, али и ванболничкој, као што је водена средина, и њена потенцијална резистенција на природне и синтетске антимикробне лекове сврстава K. pneumoniae у високо ризичне ми-кроорганизме, посебно када се ради о осетљи-вим групама као што су имунокомпромито-вани пацијенти 16 .…”

Section: Introductionunclassified

“…Thereby these resistant strains can appear not only in hospital settings, where they are the most common due to selective pressure caused by irrational use of antibiotics, but also in community [10][11][12][13][14] . Treatment of infections caused by resistant strains is growing public health problem, primarily due to limited choice of effective antimicrobial agents and absence of effective therapy 15 . Ability of this bacterial spe-Осетљивост сојева Klebsiella pneumoniae изолованих из воде за пиће и површинских вода на aнtибиотике 3 ствени проблем, пре свега због суженог избо-ра ефикасних антимикробних лекова па чак и одсуства делотворне терапије 15 .…”

Section: Introductionmentioning

confidence: 99%

Antibiotic susceptibility profile of Klebsiella pneumoniae strains isolated from drinking and surface water

Dobrijević¹,

Trudić²,

Borčić³

et al. 2017

Racion ter

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САЖЕТАКПрисуство Klebsiella pneumoniae (K. pneumoniae) у пијаћим и површинским водама представља индикатор фекалне контамина-ције хуманог и животињског порекла. K. pneumoniae има способност да стекне и пренесе гене резистенције. Изолати из животне сре-дине могу представљати резервоар ових гена који се могу пренети и на друге бактеријске врсте. Циљ рада је изолација, идентификација и тестирање антибиотске осетљивости K. pneumoniae из пијаћих и површинских вода. Про-спективна студија (спроведена од 1. октобра до 31. децембра 2015. године) испитала је 1276 узорака воде. Узорци су обрађени мем-бран-филтерском методом. За идентифика-цију K. pneumoniae коришћени су стандардни биохемијски тестови. Осетљивост на анти-биотике је тестирана диск-дифузионом мето-дом. K. pneumoniae је пронађена у 2,98% (38/1276) узорака, oд којих су 42,11% (16/38) били узорци површинских, а 57,89% (22/38) узорци пијаће воде. Teстирани изолати су били резистентни на ампицилин, док рези- ABSTRACTPresence of Klebsiella pneumoniae (K. pneumoniae) in drinking and surface water indicates fecal contamination of human or animal origin. K. pneumoniae has the ability to acquire and transfer resistance genes. Isolates found in the environment may represent a reservoir of these genes, which can be transmitted among different bacterial species. The aim of the study was identification and testing susceptibility of K. pneumoniae to antibiotics after isolation from drinking and surface water. Prospective study (conducted from October the 1 st 2015 to December the 31 st 2015) included 1276 samples of drinking and surface water. The samples were processed by membranefilter technique. Standard biochemical tests were used for identification of K. pneumoniae. Antimicrobial susceptibility was determined by diskdiffusion method. K. pneumoniae was found in 2.98% (38/1276) of samples, from both surface 42.11% (16/38) and drinking water 57.89% (22/38). Tested strains were resistant to ampicillin, but resistance to other antibiotics was not confirmed. K. pneumoniae could be found in drinking , која се описује као једна од најчешћих узрочника болничких и ванбол-ничких инфекција, јер се лако преноси кон-тактом и путем заражене хране и воде 4 . Ова бактерија има велику способност стицања и преноса гена резистенције 10,11 . Изолати који се нађу у животној средини, представљају резер-воар тих гена, који се даље могу преносити и на друге бактеријске врсте. Тиме се рези-стентни сојеви могу јавити, не само у болни-чким срединама, где су најчешћи услед се-лективног притиска насталог нерационалном употребом антибиотика, већ и у општој попу-лацији [10][11][12][13][14] . Лечење инфекција узрокованих ре-зистентним сојевима је све већи јавно-здрав-water despite the purification and chlorination. In our study strains isolated from drinking and surface water were susceptible to commonly used antibiotics, without any markers of acquired resistance.Дејан Добријевић, Aника Трудић, Владан Борчић, Maja Бекут 2 стенција на друге антибиотике није забеле

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“…The identification of the organism have special significance because it can cause large outbreaks in hospitals [30]. Below we will briefly discuss about the major groups of gram positive bacteria, which are multiresistant to various antibiotics and often is used Linezolid as alternative therapy, being first approached about the genre Enterococcus, after about the species Staphylococcus aureus [30,31].…”

Section: Gram Positive Multiresistant Bacteriamentioning

confidence: 99%

Linezolid use in Medicin Therapy against Multiresistant Bacteria-A Review

Mendes¹,

Costa²,

Paulino³

et al. 2017

J Bacteriol Parasitol

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After the description of an element with ability to combat the infectious processes originating from bacteria, starts a race for survival between the interrelationship of species, bacterial and human. With the evolution scientifictechnical, the man was able to synthesize new antibacterial substances, on the other hand the mechanisms of gene evolution enabled the emergence of multidrug-resistant bacteria. Some of this organisms are frequent on hospital environment and have high adaptability to new drugs, such as Staphylococcus aureus and Enterococcus spp. resistant to oxacillin and vancomycin, considered drugs of choice against multidrug-resistant microorganisms. So, a new antibiotics class was developed, superior to vancomycin and oxazolidinone, the linezolid. Thus, the present study aimed at understanding the use of linezolid in drug therapy against multi-resistant bacteria. To perform this study, a literature review of last 10 years was performed. In 2002, after the liberation of the use of linezolid as treatment for infectious processes against gram-positive bacteria, this drug was commonly used throughout the world. Similarly, the pressure of natural selection stood out, and there were records of resistant strains to linezolid. As prospects for control of infections caused by these resistant strains, was approved by the FDA in 2014 the use of drugs with linezolid resistant anti-strains activity. However, we conclude that, in addition to natural selection and genetic variation process, human behavior regarding the use of antibiotics, increases the selection of resistant microorganisms to antibiotic, including linezolid.

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Multiresistant Gram-negative infections: a global perspective

Abstract: Clinicians need to be aware of the rising problem of resistance in nosocomial and community-acquired Gram-negative pathogens. Novel agents are urgently needed to combat these infections and innovative infection control strategies need to be devised to protect our vulnerable patients.

Cited by 162 publications

References 110 publications

Detection of OXA-51 Carbapenemase Gene in Klebsiella pneumoniae: A Case Report and a New Dimension on Carbapenemase Resistance

Detection of OXA-51 Carbapenemase Gene in Klebsiella pneumoniae: A Case Report and a New Dimension on Carbapenemase Resistance

Antibiotic susceptibility profile of Klebsiella pneumoniae strains isolated from drinking and surface water

Linezolid use in Medicin Therapy against Multiresistant Bacteria-A Review

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