Multiregional communication and the channel modulation hypothesis

Pesaran, Bijan; Hagan, Maureen A.; Qiao, Shaoyu; Shewcraft, Ryan A.

doi:10.1016/j.conb.2020.11.016

Cited by 14 publications

(12 citation statements)

References 46 publications

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Section: Resultsmentioning

confidence: 99%

“…These were chosen because retinal stimulation was largely identical within each epoch throughout the progression of learning (see Methods). To characterize learning-related changes in synchronization between PFC and IT, we examined the oscillatory coherence between the local field potential (LFP) signals in each area, a commonly used metric that indexes transient changes in corticocortical communication during learning (Antzoulatos & Miller, 2014;Brincat & Miller, 2015;Pesaran, et al, 2021) (see Methods). To illustrate the general pattern of results, Figure 3A shows the magnitude of synchronization between the two areas, averaged across electrodes and images for both animals.…”

Section: Cortical Dynamics Of Abrupt Learningmentioning

confidence: 99%

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Long-range cortical synchronization supports abrupt visual learning

Csorba

Krause

Zanos

et al. 2021

Preprint

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Visual cortical plasticity declines sharply after the critical period, and yet we easily learn to recognize new faces and places throughout our lives. Such learning is often characterized by a moment of insight, an abrupt and dramatic improvement in recognition. We studied the brain mechanisms that support this kind of learning, using a behavioral task in which non-human primates rapidly learned to recognize visual images and to associate them with particular responses. Simultaneous recordings from the inferotemporal and prefrontal cortices revealed a transient synchronization of neural activity between these two areas that peaked around the moment of insight. This synchronization was strongest between inferotemporal sites that encoded images and prefrontal sites that encoded rewards. Moreover, its magnitude built up gradually with successive image exposures, suggesting that abrupt learning is the culmination of a search for informative visual signals within a circuit that links sensory information to task demands.

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Section: Resultsmentioning

confidence: 99%

Section: Cortical Dynamics Of Abrupt Learningmentioning

confidence: 99%

Long-range cortical synchronization supports abrupt visual learning

Csorba

Krause

Zanos

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…These were chosen because retinal stimulation was largely identical within each epoch throughout the progression of learning (see Methods). To characterize learning-related changes in synchronization between PFC and IT, we examined the oscillatory coherence between the local field potential (LFP) signals in each area, a commonly used metric that indexes transient changes in corticocortical communication during learning 26,27 (see Methods). To illustrate the general pattern of results, Figure 3A shows the magnitude of synchronization between the two areas, averaged across electrodes and images for both animals.…”

Section: Cortical Dynamics Of Abrupt Learningmentioning

confidence: 99%

Long-range cortical synchronization supports abrupt visual learning

et al. 2022

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“…We use behavioral task design to decompose a naturally-expressed behaviour into components necessary to test the mechanisms of multiregional communication by single neurons 36,37 . Gaze-anchoring isolates communication from the reach system to the saccade system.…”

Section: Fig 4g)mentioning

confidence: 99%

Modulation of inhibitory communication coordinates looking and reaching

Pesaran

2020

Preprint

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Understanding how natural behaviors are controlled depends on understanding the neural mechanisms of multiregional communication. Eye-hand coordination, a natural behavior shared by primates, is controlled by the posterior parietal cortex (PPC), a brain structure that expanded substantially in primate evolution. Here, we show that neurons within the saccade and reach regions within PPC communicate over a visuomotor channel to coordinate looking and reaching.During gaze-anchoring behavior, when saccades are transiently-inhibited by coordinated reaches, PPC neuron firing rates covary with beta-frequency (15-25 Hz) neuronal coherence.Decreases in parietal saccade neuron spiking correlated with gaze-anchoring behavior when the channel was "open" and not "closed". Functional inhibition across beta-frequency-coherent communication channels may be a general mechanism for flexibly coordinating our natural behavior.One Sentence Summary Inhibitory communication through a visuomotor channel mediates the coordination of eye and hand movements. Main textThe primate visual system contains multiple information processing channels that transform and transmit object-based information, such as identity, shape, color, form, location, and motion (1). The visual cortices project to the posterior parietal and frontal cortices which expanded substantially in primate evolution (2, 3) and further transform visual information according to the goals of movement, in visuomotor channels that ultimately generate motor commands (4, 5). In each case, channels support communication between distinct groups of neurons in an anatomical pathway. Communication channels may also flexibly integrate information across sensory and motor pathways to support more complex behaviors (6). Eyehand coordination, which combines binocular, foveal vision and manual dexterity in a flexible, natural behavior, provides an excellent example. We coordinate saccadic eye movements to foveate targets and make accurate reach-and-grasp movements (7,8). The parietal reach and saccade regions are necessary for coordinated behavior (4, 5) and are anatomically separate yet interconnected (9). Consequently, a visuomotor communication channel may support multiregional communication to coordinate looking and reaching.Here we investigate the temporal coordination of looking and reaching in a behavioral coordination strategy called gaze-anchoring, originally demonstrated in humans (10,11). In gaze-anchoring, during and shortly after coordinated look-and-reach movements, saccades to newly-presented targets have longer latencies, as if gaze is anchored to the target of the ongoing reach. Gaze-anchoring momentarily extends foveal vision around coordinated movements and improves movement accuracy by allowing coordinated reaches to inhibit upcoming saccades. We hypothesized that multiregional communication over a communication channel allows neurons in the parietal reach system to inhibit neurons in the parietal saccade system in order to transiently inhibit eye movements to newly-presen...

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Multiregional communication and the channel modulation hypothesis

Cited by 14 publications

References 46 publications

Long-range cortical synchronization supports abrupt visual learning

Long-range cortical synchronization supports abrupt visual learning

Long-range cortical synchronization supports abrupt visual learning

Modulation of inhibitory communication coordinates looking and reaching

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