“…26-29 Optimizing surgery by combining multiple ports allows to optimize visualization, trajectory, and working distance, and to maximize the working space between the surgeon's hands and instruments. 6,25,30 In this context, the SE transorbital approach appeared to be a natural complementary route to the endonasal pathway, providing an avenue that gets access to paramedian space. These ideas, well defined in the anatomic laboratory setting, 1,2,4,8,31-33 boosted the endoscopic transorbital approach to access, in clinical practice, the lateral portion of the middle skull base, particularly cavernous sinus and Meckel cave lesions.…”