Multiplexing System for Automated Characterization of a Capacitive Field‐Effect Sensor Array

Abstract

In comparison to single‐analyte devices, multiplexed systems for a multi‐analyte detection offer a reduced assay time and sample volume, low costs and high throughput. In this work, a multiplexing platform for an automated quasi‐simultaneous characterization of multiple (up to sixteen) capacitive field‐effect sensors by the capacitive‐voltage (C−V) and the constant‐capacitance (ConCap) mode is presented. The sensors were mounted in a newly designed multi‐cell arrangement with one common reference electrode and electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user‐defined measurement protocol. The developed multiplexing system was tested for pH measurements and the label‐free detection of ligand‐stabilized, charged gold nanoparticles.This article is protected by copyright. All rights reserved.