Multiplexing of Microelectrode Arrays in Voltammetric Measurements

Abstract

Multipotentiostats are the equipment commonly used for voltammetric measurements with multichannel electrode arrays, because the conditioning of the working electrodes does not allow fast multiplexing for measuring current responses. In this article, multiplexing and serial read‐out of electrode arrays using a simple potentiostat and integrated circuits are shown. Several specially constructed switches, which were integrated in an application specific integrated circuit (ASIC) in complementary metal oxide semiconductor (CMOS) technology, allow electrode potentials to be applied as if by a potentiostat during the read‐out time as well as continuously applying a bias voltage during stand‐by. The application of multiplexing and serial read‐out is demonstrated by redox recycling of p‐aminophenol in an interdigitated microelectrode array made in silicon technology. Here, a bipotentiostat generates two different potentials that are addressed by the ASIC to the anodes and cathodes for redox recycling. The results show the same quality as those using a multipotentiostat.

Multichannel Measuring Complex for Electrochemical Measurements

“…Âàaeíîå çíà÷åíèå èìååò ðàçðàáîòêà ìóëü-òèñåíñîðíûõ ñèñòåì, ñîäåðaeàùèõ íåñêîëüêî èçìåðèòåëüíûõ ýëåêòðîäîâ ñ ðàçëè÷íûìè ìåì-áðàíàìè [4,5]. Îíè ïîçâîëÿþò àíàëèçèðîâàòü ìíîãîêîìïîíåíòíûå ðàñòâîðû, áûñòðî è òî÷íî îïðåäåëÿòü ñîîòíîøåíèå êîíöåíòðàöèé íå-ñêîëüêèõ ñîäåðaeàùèõñÿ â íèõ âåùåñòâ.…”

Miniaturization in functional genomics and proteomics

“…Siliconbased electrical biochips have been developed and use redox-recycling reactions on interdigitated ultramicroelectrodes that are arranged in array formats 118 . Binding events can be monitored by redox-recycling of products, which is generated through enzyme labelling of affinity complexes 119 . The principles of this method can be extended to other formats such as integrated 'lab-on-achip' devices or metal nanoparticles.…”

Miniaturization of electroanalytical systems

“…Arrays of individually addressable microelectrodes enable multicomponent analysis or spatially resolved studies. Measurements can be performed either by using a multichannel potentiostat or by multiplexing of the electrode arrays [10]. The latter approach is particularly straightforward and might become the strategy of choice for future developments.…”