Multiplexed Processing of Vibrotactile Information in the Mouse Primary Somatosensory Cortex

Kim, Yoo Rim; Kim, Chang Eop; Yoon, Hye Sun; Kim, Sun Kwang; Kim, Sang Jeong

doi:10.5607/en20041

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…Previous studies have found that S1 responds not only to pain and itch but also to other sensations. 7 , 10 , 11 , 17 , 18 , 31 Similarly, we found that several neurons in the S1 hind paw region were activated by intradermal injection of formalin or CQ into the hind paw. Results of in vivo two-photon calcium imaging showed these neuronal populations that responded to acute chemical stimulation did not exactly coincide.…”

Section: Discussionsupporting

confidence: 60%

Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety

Ishikawa¹,

Murata²,

Okuda³

et al. 2023

iScience

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Section: Discussionsupporting

confidence: 60%

Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety

Ishikawa¹,

Murata²,

Okuda³

et al. 2023

iScience

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“…We propose that the S1 neurons adopt a multiplexed coding strategy for itch and pain sensations. The coding strategy explains that the sensory system processes distinct sensations by both specific cell populations and converged cell populations [ 19 , 33 ]. These coding strategies were found at the supraspinal level, including S1 [ 18 , 19 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…The coding strategy explains that the sensory system processes distinct sensations by both specific cell populations and converged cell populations [ 19 , 33 ]. These coding strategies were found at the supraspinal level, including S1 [ 18 , 19 , 34 ]. When we classified the preferred cells, we disregarded the activities of counter pair.…”

Section: Resultsmentioning

confidence: 99%

“…Primary somatosensory cortex (S1) plays a crucial role in the perception and discrimination of somatosensory information, including touch, itch, and pain [ 15 - 17 ]. Recent studies have shown that S1 encodes the sub-modality of somatic sensations using multiplexed strategies [ 18 , 19 ]. In other reports, the activation of the S1 layer 5 neurons projecting to the spinal cord decreased itch; meanwhile, activation of these neurons could facilitate mechanical allodynia.…”

Section: Introductionmentioning

confidence: 99%

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Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex

et al. 2022

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Itch and pain are distinct sensations that share anatomically similar pathways: from the periphery to the brain. Over the last decades, several itchspecific neural pathways and molecular markers have been identified at the peripheral and spinal cord levels. Although the perception of sensation is ultimately generated at the brain level, how the brain separately processes the signals is unclear. The primary somatosensory cortex (S1) plays a crucial role in the perception of somatosensory information, including touch, itch, and pain. In this study, we investigated how S1 neurons represent itch and pain differently. First, we established a spontaneous itch and pain mouse model. Spontaneous itch or pain was induced by intradermal treatment with 5-HT or capsaicin on the lateral neck and confirmed by a selective increase in scratching or wiping-like behavior, respectively. Next, in vivo two-photon calcium imaging was performed in awake mice after four different treatments, including 5-HT, capsaicin, and each vehicle. By comparing the calcium activity acquired during different sessions, we distinguished the cells responsive to itch or pain sensations. Of the total responsive cells, 11% were both responsive, and their activity in the pain session was slightly higher than that in the itch session. Itch-and painpreferred cells accounted for 28.4% and 60.6%, respectively, and the preferred cells showed the lowest activity in their counter sessions. Therefore, our results suggest that S1 uses a multiplexed coding strategy to encode itch and pain, and S1 neurons represent the interaction between itch and pain.

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Multiplexed Processing of Vibrotactile Information in the Mouse Primary Somatosensory Cortex

Cited by 2 publications

References 26 publications

Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety

Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety

Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex

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