Multiplexed Electrochemical Detection of Three Cardiac Biomarkers cTnI, Ctnt and Bnp Using Nanostructured ZnO-sensing Platform

Shanmugam, Nandhinee Radha; Muthukumar, Sriram; Tanak, Ambalika Sanjeev; Prasad, Shalini

doi:10.2217/fca-2017-0074

Cited by 34 publications

(19 citation statements)

References 22 publications

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“…[16][17][18] BNP and cTnI are commonly used cardiac biomarkers. 19 In recent years, it has been found that BNP and cTnI are closely related to myocardial systolic dysfunction. 20 In SS, in addition to the direct action of inflammatory cytokines, the immunopathological response of the complement system and the imbalance of the autonomic nervous system, the dysfunction of mitochondria and abnormal energy metabolism can also lead to myocardial apoptosis and myocardial remodeling.…”

Section: Discussionmentioning

confidence: 99%

Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock

Kang

Xia

et al. 2020

Int J Immunopathol Pharmacol

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Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS. SS patients received NE treatment at different administration time and NE combined with SP treatment were enrolled in this study. The serum levels of cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP), ejection fraction (EF), and pressure-adjusted heart rate (PAR) value were analyzed to evaluate cardiac function. The 28-day survival information was collected and assessed using the Kaplan-Meier method and log-rank test. The cardiac function of SS patients was improved significantly by NE treatment, especially in the patients received NE at 2 h after fluid infusion, which evidenced by the increased BNP and cTnI levels and EF% and the decreased RAP. In the NE-2 h group, SS patients had a better 28-day survival rate compared with those patients in NE-1 h and -3 h groups. Furthermore, the significantly improved cardiac function and survival outcomes were found in patients received NE combined SP treatment. Taken together, this study results show that NE administration at 2 h after fluid infusion may be the optimal time point for the treatment of SS and NE combined with SP treatment can improve early cardiac dysfunction and 28-day survival outcomes in patients with SS.

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Section: Discussionmentioning

confidence: 99%

Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock

Kang

Xia

et al. 2020

Int J Immunopathol Pharmacol

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“…The EC TN detection method is suitable for those requirements [13,22,27]. The EC TN detection method offers portability (electrode size miniaturized through nano/microtechnology), modularity (can be integrated with a smartphone or arduino-based device), minimal requirements for sample volume, and short measurement time [28,29,30]. Usually, EC TN detection can be achieved by such methods as voltammetric, potentiometric, conductometric, amperometric, and impedimetric techniques [31,32,33].…”

Section: Ec-based Tn Detection System With Nanostructurementioning

confidence: 99%

Development of the Troponin Detection System Based on the Nanostructure

et al. 2019

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During the last 30 years, the World Health Organization (WHO) reported a gradual increase in the number of patients with cardiovascular disease (CVD), not only in developed but also in developing countries. In particular, acute myocardial infarction (AMI) is one of the severe CVDs because of the high death rate, damage to the body, and various complications. During these harmful effects, rapid diagnosis of AMI is key for saving patients with CVD in an emergency. The prompt diagnosis and proper treatment of patients with AMI are important to increase the survival rate of these patients. To treat patients with AMI quickly, detection of a CVD biomarker at an ultra-low concentration is essential. Cardiac troponins (cTNs), cardiac myoglobin (cMB), and creatine kinase MB are typical biomarkers for AMI detection. An increase in the levels of those biomarkers in blood implies damage to cardiomyocytes and thus is related to AMI progression. In particular, cTNs are regarded as a gold standard biomarker for AMI diagnosis. The conventional TN detection system for detection of AMI requires long measurement time and is labor-intensive and tedious. Therefore, the demand for sensitive and selective TN detection techniques is increasing at present. To meet this demand, several approaches and methods have been applied to develop a TN detection system based on a nanostructure. In the present review, the authors reviewed recent advances in TN biosensors with a focus on four detection systems: (1) An electrochemical (EC) TN nanobiosensor, (2) field effect transistor (FET)-based TN nanobiosensor, (3) surface plasmon resonance (SPR)-based TN nanobiosensor and (4) surface enhanced Raman spectroscopy (SERS)-based TN nanobiosensor.

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“…Due to the great importance of the BNP biomarker in CVD diagnosis, analytical immunosensors have been developed for detecting BNP in samples of human serum and whole blood, such as those using transducers based on the field‐effect transistor [9], surface plasmon resonance [10] and photoelectrochemical methods [11]. Given the nanotechnology advances, new emerging technologies constructed on the electrochemical screen‐printed electrode have gained particular attention as an essential analytical tool due to their portability, sensitivity and rapid responses, besides the advantages of large‐scale production with low‐cost [12, 13]. Some approaches based on screen‐printed electrodes have been developed for the BNP [14].…”

Section: Introductionmentioning

confidence: 99%

A Novel Redox‐free Immunosensor Concept Based on Cobalt Phthalocyanine@carbon Nanotubes Pseudocapacitor for Cardiac B‐type Natriuretic Peptide Detection

et al. 2021

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B‐type natriuretic peptide (BNP) is a selective biomarker for cardiac diagnosis and prognosis of patients with cardiac insufficiency or heart failure, which means the pump function of cardiac muscle is reduced. A pseudocapacitive immunosensor was developed based on faradaic currents generated by a reduction‐reaction with a metallocyanine modified‐carbon nanotube surface. This technique is based on changes in interface by antigen‐antibody interactions, which perturbs the dependent‐diffusion potential reducing the charge transfers proportionally to the BNP captured. This new concept allows new perspectives for point‐of‐care tests since it is simpler and faster to manage with direct measurements of samples than conventional immunosensors.

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Multiplexed Electrochemical Detection of Three Cardiac Biomarkers cTnI, Ctnt and Bnp Using Nanostructured ZnO-sensing Platform

Cited by 34 publications

References 22 publications

Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock

Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock

Development of the Troponin Detection System Based on the Nanostructure

A Novel Redox‐free Immunosensor Concept Based on Cobalt Phthalocyanine@carbon Nanotubes Pseudocapacitor for Cardiac B‐type Natriuretic Peptide Detection

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