Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer
Topias Karjula,
Hanna Elomaa,
Sara A. Väyrynen
et al.
Abstract:Tumour-associated macrophages (TAMs) express a continuum of phenotypes ranging from an anti-tumoural M1-like phenotype to a pro-tumoural M2-like phenotype. During cancer progression, TAMs may shift to a more M2-like polarisation state, but the role of TAMs in CRC metastases is unclear. We conducted a comprehensive spatial and prognostic analysis of TAMs in CRC pulmonary metastases and corresponding primary tumours using multiplexed immunohistochemistry and machine learning-based image analysis. We obtained dat… Show more
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