Multiplex Fluorescence In Situ Hybridization and Cross Species Color Banding of a Case of Chronic Myeloid Leukemia in Blastic Crisis with a Complex Philadelphia Translocation

Harrison, Christine J.; Gibbons, Barbara; Yang, Fengtang; Butler, Tina; Cheung, Kan-Luk; Kearney, Lyndal; Dirscherl, Luke; Bray‐Ward, Patricia; Gregson, M; Ferguson‐Smith, Malcolm A.

doi:10.1016/s0165-4608(99)00116-8

Cited by 22 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only intrachromosomal abnormalities, such as inversions, escaped detection. Color banding, which uses gibbon instead of human chromosomespecific probes, had higher resolution as it produces color bands along human chromosomes (Figure 1), and this helped with the detection of intrachromosomal abnormalities (73,96). M-FISH continues to have practical application in analyzing constitutional aberrations and the multiple rearrangements found in cancer cells (16,95).…”

Section: Chromosome Sorting and Paintingmentioning

confidence: 99%

Putting Medical Genetics into Practice

Ferguson-Smith

2011

Annu. Rev. Genom. Hum. Genet.

View full text Add to dashboard Cite

This article describes a fragment of history on the growing impact of genetics on the practice of medicine over 50 years, as experienced by a medical geneticist who helped to provide services to patients at risk of genetic disorders. It is a personal account influenced by a fascination with chromosomes that has drawn him into many studies, including sex determination, gene discovery, fetal diagnosis, phylogenomics, and karyotype evolution.

show abstract

Section: Chromosome Sorting and Paintingmentioning

confidence: 99%

Putting Medical Genetics into Practice

Ferguson-Smith

2011

Annu. Rev. Genom. Hum. Genet.

View full text Add to dashboard Cite

show abstract

“…Some of the probes were labeled with biotin-dATP and then detected with diethylaminocoumarin (DEAC)-conjugated streptavidin. FISH was performed as previously described [22]. Digital images were obtained using a Leica DM-RXA2 epifluorescence microscope equipped with a cooled CCD camera (Princeton Instruments, Boston, MA).…”

Section: Fish Studiesmentioning

confidence: 99%

t(5;6;12) associated with resistance to imatinib mesylate in chronic myeloid leukemia

Denčić‐Fekete¹,

Đorđević²,

Storlazzi

et al. 2009

Int J Hematol

View full text Add to dashboard Cite

A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This is the first reported instance of karyotype evolution temporally associated, and possibly involved, with the induction of resistance to imatinib mesylate but without any signs of evolution of leukemia toward a more anaplastic and aggressive form.

show abstract

“…However, they were particularly useful for the detection of tumor-specific chromosomal aberrations and of chromosome rearrangements that occurred during primate evolution. RxFISH has successfully been used to screen solid tumors (Micci et al, 1999;Kim et al, 2001) and haematological malignancies (Espinet et al, 2000;Harrison et al, 2000Harrison et al, , 2001Sole et al, 2001). In all cases previously unidentified intra-as well as inter-chromosomal rearrangements were detected, thus demonstrating the potential of this approach for the accurate characterization of complex rearrangements with subtle abnormalities.…”

Section: Bar Codes For Whole Karyotype Aberration Screeningmentioning

confidence: 99%

Multicolor chromosome bar codes

Müller

Wienberg

2006

Cytogenet Genome Res

View full text Add to dashboard Cite

Chromosome bar codes are multicolor banding patterns produced by fluorescence in situ hybridization (FISH) with differentially labeled and pooled sub-regional DNA probes. These molecular cytogenetic tools facilitate chromosome identification and the delineation of both inter- and intra-chromosomal rearrangements. We present an overview of the various conceptual approaches which can be largely divided into two classes: Simple bar codes designed for chromosome identification and complex bar codes for high resolution aberration screening of entire karyotypes. We address the issue of color redundancy and how to overcome this limitation by complementation of bar codes with whole chromosome painting probes.

show abstract

Multiplex Fluorescence In Situ Hybridization and Cross Species Color Banding of a Case of Chronic Myeloid Leukemia in Blastic Crisis with a Complex Philadelphia Translocation

Cited by 22 publications

References 16 publications

Putting Medical Genetics into Practice

Putting Medical Genetics into Practice

t(5;6;12) associated with resistance to imatinib mesylate in chronic myeloid leukemia

Multicolor chromosome bar codes

Contact Info

Product

Resources

About