Multiplex antibacterial processes and risk in resistant phenotype by high oxidation-state nanoparticles: New killing process and mechanism investigations

Hsu, I-Lin; Yeh, Fang Hao; Chin, Yu‐Cheng; Cheung, Chun In; Chia, Zi Chun; Yang, Li‐Xing; Chen, Ya-Jyun; Cheng, Tsung Chieh; Wu, Shu-Pao; Tsai, Pei-Jane; Lee, Nan-Yao; Liao, Mei‐Yi; Huang, Chih‐Chia

doi:10.1016/j.cej.2020.128266

Cited by 18 publications

(25 citation statements)

References 46 publications

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“…An aliquot of the BG-AgNP solution (5 mL) was harvested after 0.5, 1, 3, 6, and 24 h of aging periods. After centrifugation at 15,000× g for 20 min, the resulting supernatant solutions were collected and diluted with 5 M nitric acid for the measurement of Ag concentrations using atomic absorption spectrophotometry (AAS) [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Systematic Evaluation of Antioxidant Efficiency and Antibacterial Mechanism of Bitter Gourd Extract Stabilized Silver Nanoparticles

Moorthy

Chang

et al. 2021

Nanomaterials

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In this study, we accentuate the facile and green synthesis of ecologically viable silver nanoparticles (AgNPs) using aqueous (A-BGE) and ethanolic (E-BGE) dried bitter gourd (Momordica charantia) fruit extract as reducing and capping agents. Although AgNPs synthesized using BGEs have been reported earlier in fundamental antimicrobial studies, the possible antioxidant activity, antibacterial efficacy against superbugs, and a potential antimicrobial mechanism are still lacking. The characterization of as-prepared AgNPs was studied through UV-vis, TEM, Zeta-potential, FT-IR, XRD, and XPS analysis. The antioxidant ability of BG-AgNPs was extensively evaluated through DPPH and FRAP assays, which showed that A-BG-AgNPs possessed higher scavenging ability and superior reducing power due to the high phenolic content present in the BG extract. Furthermore, A-BG-AgNPs were highly stable in various physiological media and displayed excellent antibacterial activity against drug-resistant bacterial strains (i.e., MIC value of 4 µg/mL). The generation of reactive oxygen species evidenced that the possible antimicrobial mechanism was induced by BG-AgNPs, resulting in bacterial cell damage. Within the minimal hemolysis, the BG-mediated AgNPs possessed synergistic antioxidant and antibacterial agents and open another avenue for the inhibition of the growth of pathogens.

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Section: Methodsmentioning

confidence: 99%

Systematic Evaluation of Antioxidant Efficiency and Antibacterial Mechanism of Bitter Gourd Extract Stabilized Silver Nanoparticles

Moorthy

Chang

et al. 2021

Nanomaterials

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“…Nanomaterials have been extensively applied in various fields, such as medicine, materials science, and energy application [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Recently, cancer nanotechnology has been developed to treat cancer based on nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy

et al. 2022

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Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment. To date, the development of a better drug delivery system based on lipid nanomaterials is still urgent to make the treatment and diagnosis easily accessible to breast cancer patients. In a drug delivery system, lipid nanomaterials have revealed distinctive features, including high biocompatibility and efficient drug delivery. Specifically, a targeted drug delivery system based on lipid nanomaterials has inherited the advantage of optimum dosage and low side effects. In this review, insights on currently used potential lipid-based nanomaterials are collected and introduced. The review sheds light on conjugation, targeting, diagnosis, treatment, and clinical significance of lipid-based nanomaterials to treat breast cancer. Furthermore, a brighter side of lipid-based nanomaterials as future potential drug delivery systems for breast cancer therapy is discussed.

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“…In addition to, several nanoparticle-based systems also exhibited both anticancer and antibacterial abilities, such as iron oxide nanoparticles and carbon-related materials ( Chu et al, 2013 ; Huang et al, 2015 ; Yu and Chi, 2020 ; Bayda et al, 2021 ; Te and Wei, 2022 ). In contrast, silver (Ag) nanoparticles possess a remarkable antibacterial and anticancer activity and have been widely used in medicine with significant applications including antimicrobial, bioimaging, and cancer therapy ( Tang and Zheng, 2018 ; Deshmukh et al, 2019 ; Ahn and Park, 2020 ; Eid et al, 2020 ; Xu et al, 2020 ; Hsu et al, 2021 ; Bi et al, 2022 ). Compared to conventional anticancer drugs, QASs and Ag nanoparticles are cheaper and easier to use.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Developing drug delivery nanosystems with both anticancer and antibacterial effects is of great clinical value. Herein, we report a facile approach to synthesize Ag and quaternary ammonium salt (QAS) co-decorated mesoporous silica nanoparticles (MSNs), namely, Ag/QAS-MSNs, for synergistic treatment of cancer and bacterial infections. In vitro studies demonstrated that Ag/QAS-MSNs not only had a strong antibacterial activity against the bacterial pathogens but also could efficiently induce cancer cell death through an apoptotic pathway. Moreover, in vivo combination therapy with Ag and QAS in Ag/QAS-MSNs was also tested in a nude mouse tumor model, and a significant synergistic anticancer effect, which is superior to that obtained by therapy with Ag-MSNs or QAS-MSNs alone, was achieved. Such excellent anticancer and antibacterial activity of Ag/QAS-MSNs could be attributed to the synergistic effect of Ag ions and QAS. Thus, Ag/QAS-MSNs have a promising future as potent anticancer agents with high antibacterial performance.

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Multiplex antibacterial processes and risk in resistant phenotype by high oxidation-state nanoparticles: New killing process and mechanism investigations

Cited by 18 publications

References 46 publications

Systematic Evaluation of Antioxidant Efficiency and Antibacterial Mechanism of Bitter Gourd Extract Stabilized Silver Nanoparticles

Systematic Evaluation of Antioxidant Efficiency and Antibacterial Mechanism of Bitter Gourd Extract Stabilized Silver Nanoparticles

Lipid-Based Nanomaterials for Drug Delivery Systems in Breast Cancer Therapy

One-Pot Synthesis of Ag/Quaternary Ammonium Salt Co-Decorated Mesoporous Silica Nanoparticles for Synergistic Treatment of Cancer and Bacterial Infections

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