Multiplex advantage and peak resolution in correlation chromatography

Kaljurand, Mihkel; Koel, Mihkel; Küllik, E.

doi:10.1016/s0003-2670(00)83869-6

Cited by 8 publications

(6 citation statements)

References 2 publications

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“…Compared to single injection chromatograms, the correlograms still have a higher signal to noise ratio. This results from the multiplex advantage of CC [21]. Chromatograms obtained from Tenax generally exhibit some resemblance to the single injection chromatogram pattern, although the peak intensity distribution does not coincide with that of single injection chromatogram.…”

Section: Figurementioning

confidence: 96%

Comparison of sample concentration methods and correlation chromatography for polymer dynamic head-space studies

Kaljurand

Smit

1994

Chromatographia

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SummaryGas chromatography has been used to study the kinetics of evolution of volatiles from polypropylene samples (at 70 ~ Correlation chromatography (CC) and the trapping of volatiles on Tenax sorbents and activated charcoal were employed to improve the detector signal. As a reference, the kinetics of gas evolution was studied by making a series of direct single injections of polymer head-space gas on a GC column. The results of trapping differed from those obtained by single injection. However, the data from single injections and CC were in good agreement. The CC method was found to offer far more operator convenience for dynamic head-space analysis than sample trapping, being less subject to operator errors.

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Section: Figurementioning

confidence: 96%

Comparison of sample concentration methods and correlation chromatography for polymer dynamic head-space studies

Kaljurand

Smit

1994

Chromatographia

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“…Konzentrationsschwankungen können auf diese Weise schnell und präzise detektiert werden. Kaljurand et al verwendeten pseudo-zufällige Injektionssequenzen mit 63 Elementen bei der kontinuierlichen Analyse der Pyrolyse von Polymeren in der GC [30,31]. Die S/N-Verstärkung war hierbei optimal für kleine Probenvolumina und -konzentrationen.…”

Section: Multiplexing-techniken In Der Gaschromatographieunclassified

High‐Throughput Multiplexing Gas Chromatography

Siegle

Trapp

2014

Chemie Ingenieur Technik

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High-Throughput Multiplexing Gas ChromatographyThe utilization of information technology in gas chromatography is demonstrated. Multiplexing gas chromatography enhances the overall duty cycle, signal-to-noise ratio and enables achieving extraordinarily high sample throughputs. Parameters such as sequence length, modulation interval and number of repetitive injections in the high-throughput mode determine overall performance of such systems. The portrayed technique opens new perspectives in process analytics by allowing continuous monitoring of chemical processes while analyzing the complete spectrum of analytes.

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“…Since the introduction of mpGC in 1967, several very fast gas injection systems, which define the sample volume via gas volume flow and time, have been designed and tested for mpGC. Such an injection can take place by controlling the time for opening and closing of solenoid valves ,,,, or with fluidic switching elements like a bistable fluidic amplifier or a deans switch. , According to Hagen–Poiseuille’s law, a laminar volume flow along a pipe depends also on the viscosity of the sample. In cases where concentrations and therefore also the viscosity of the sample are changing, injecting reproducible sample volumes via controlling the duration of a volume flow is not possible.…”

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Online High Throughput Measurements for Fast Catalytic Reactions Using Time-Division Multiplexing Gas Chromatography

et al. 2018

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Developing new catalysts is crucial for optimization of chemical processes. Thus, advanced analytical methods are required to determine the catalytic performance of new catalysts accurately. Usually, gas chromatographic methods are employed to analyze quantitatively the product distribution of volatile compounds generated by a specific catalyst. However, the characterization of rapidly changing catalysts, e.g., due to deactivation, still poses an analytical challenge because gas chromatographic methods are too slow for monitoring the change of the complex product spectra. Here, we developed a gas chromatographic technique based on the concept of multiplexing gas chromatography (mpGC) for fast and comprehensive analysis of the product stream from a catalytic testing unit. This technique is applied for the study of the catalytic reaction of methanol-to-olefins (MTO) conversion. For this method, the time distance between two measurements is chosen so that the chromatograms but not the peaks themselves are superimposed. In this way, stacked chromatograms are generated in which the components from successively injected samples elute baseline separated next to each other from the column. The peaks from different samples are interlaced, and for this reason, the method is referred to as time-division multiplexing gas chromatography (td-mpGC). The peaks are analyzed by direct peak integration not requiring a Hadamard transformation for deconvolution of the raw data as usual for many mpGC applications. Therefore, the sample can be injected equidistantly. The integrated peaks have to be allocated to the correct retention times. The time distance between two measurements for studying the reaction and regeneration cycles of MTO catalysts is 4.3 min and 38 s, respectively. Column switching techniques such as back-flush and heart-cut are introduced as general tools for multiplexing gas chromatography.

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Multiplex advantage and peak resolution in correlation chromatography

Cited by 8 publications

References 2 publications

Comparison of sample concentration methods and correlation chromatography for polymer dynamic head-space studies

Comparison of sample concentration methods and correlation chromatography for polymer dynamic head-space studies

High‐Throughput Multiplexing Gas Chromatography

Online High Throughput Measurements for Fast Catalytic Reactions Using Time-Division Multiplexing Gas Chromatography

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