Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved fertility and ovarian function of perimenopausal mice undergoing natural aging.
Eun-Young Shin,
Suji Jeong,
Jeoung Eun Lee
et al.
Abstract:Objectives: There is no approved therapy to preserve ovarian health with aging. To solve this problem, we developed a long-term treatment of human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs) and investigated whether the cells retained the ability to resist ovarian aging, leading to delayed reproductive senescence.
Materials and Methods: In a middle-aged female model undergoing natural aging, we analyzed whether hESC-MPCs have a beneficial effect on the long-term maintenance of reproduc… Show more
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