Multiple TL-like loci in the grc-G/C region of the rat

Kirisits, Michael J.; Sawai, Hideaki; Kunz, Heinz W.; Gill, Thomas J.

doi:10.1007/bf00189226

Cited by 18 publications

(9 citation statements)

References 35 publications

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“…MHC-related genes may map to two or more different chromosomes in chickens, Xenopus, and fish. The rat map is mostly from Gill (1994). The chicken map is based partly on personal communications from J. Kaufman; the class II A gene shown on the left is linked to cluster I but by > 5 cM and could be on either side.…”

Section: The Mhc Gene Clustermentioning

confidence: 99%

?Both man & bird & beast?: comparative organization of MHC genes

1995

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Section: The Mhc Gene Clustermentioning

confidence: 99%

?Both man & bird & beast?: comparative organization of MHC genes

1995

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“…C side of the class IUIII region using a different set of recombinants (Wang et al 1995), and it is likely that RT1.M3 also maps in the RT1.M region. Because the H2-T region is located proximal-to the H2-M region in the mouse, it was of interest to see whether the rat homologs of H-2T genes, RT1.N1, N2, and N3 (Kirisits et al 1994), are separated 2.3 from the RT1.M genes by the crossover in r38. Therefore, we analyzed rat H2-T homologous genes with the rat probe 5' pMK (Kirisits et al 1994).…”

Section: Mapping Of H2-m Homolog and Mog Genes In The Rat Mhcmentioning

confidence: 99%

“…Because the H2-T region is located proximal-to the H2-M region in the mouse, it was of interest to see whether the rat homologs of H-2T genes, RT1.N1, N2, and N3 (Kirisits et al 1994), are separated 2.3 from the RT1.M genes by the crossover in r38. Therefore, we analyzed rat H2-T homologous genes with the rat probe 5' pMK (Kirisits et al 1994). However, we found no potymorphism differentiating haplotypes l and n, and it has not yet been possible to determine their location relative to the recombination point in r38.…”

Section: Mapping Of H2-m Homolog and Mog Genes In The Rat Mhcmentioning

confidence: 99%

Mapping of H2-M homolog and MOG genes in the rat MHC

Lambracht

Prokop

et al. 1995

Immunogenetics

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Class I genes of the rat major histocompatibility complex (MHC; RTI system) are encoded by two subregions, which are separated by regions coding for class II (RT1.B/D) and class III molecules. By convention, the RT1.A region is left of the class II region; it codes for one or very few classical class I molecules. The RT1. C/E region, located on the other side of the RT1 complex, contains a large number of class I genes (Jameson et al. 1992). The internal organization of this extended class I region has not been defined in detail. It is therefore of interest that genes similar to H2-M genes, which are the most distal group of class I genes in the mouse, have been demonstrated in the rat (Wang et al. 1991(Wang et al. , 1995. The rat genes similar to H2-M genes are now called RT1.M genes, and they are different from the previously defined oligomorphic class I gene RT1.M (Wonigeit and Hfinisch 1991), which has been renamed RT1. R (Gill et al. 1995). A homolog of the H2-M3 gene has been isolated, and the sequence of RT1.M3 cDNA is 88% identical to H2-M3 (Wang et al. 1995). RT1.M3 as well as homologs of H2-M2 and H2-M4 have been mapped with established recombinant haplotypes to the extended class I region on the RT1. C/E side of the class II/III region (Wang et al. 1995). We now report on a new recombinant haplotype, r38, derived from the parental strains LEW (RTIO and BN (RTIn), in which the rat homologs of H2-M2 and H2-M4 are separated from other class I genes that differ between haplotypes l and n. This recombinant defines a new class I subregion beyond RT1.C. It also permitted mapping of the rat gene that codes for the myelin/oligodendrocyte glycoprotein (MOG) to this region of the RT1 complex.Haplotype r38 was found in a detailed analysis of the LXB family of 12 recombinant inbred (RI) rat strains. The progenitor strains of this RI strain set are LEW and BN (Hedrich 1990). Accordingly, the individual strains are expected to possess either the RT1 l or the RT1 n haplotype. Of the 12 RI strains analyzed, eight had previously been shown to possess the RT1.A and RT1.B/D region of the RT1 l haplotype and four the RT1.A and RT1.B/D region of RTln. Serological typing for the polymorphic RTI.C region gene, RT1.C 1, present in the RT11 but not the RT1 n haplotype, gave concordant results, demonstrating that in all strains the RT1.C gene has been derived from the same parental haplotype as the RT1.A and RT1.B/D regions. This was confirmed by restriction fragment length polymorphism (RFLP) analysis with the rat class I probe pWW6.3 encoding the extracellular part of a rat class I molecule (Wurst 1988), which detects the RT1.A gene as well as multiple class I genes mapping to the RT1.C/E region (Fig. 1).Haplotype-specific patterns for the RT1.M genes, differentiating l and n, could be demonstrated with the H2-M2 probe after digestion of genomic DNA with Hin dII, and with the H2-M4 probe after digestion with Barn HI, Hin dIlI, or Pvu II (Table 1; Fig. 2). One RI strain, LXB17L, showed a deviant result: although typing as 1 in...

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“…One of these, RT 1.C, has been shown to be functional and does indeed contain the H-2 BF1 target sequence (32). Of the three remaining isolates, two are functional but are TLa-like (33,34), and the third is a pseudogene (35). Two swine genes were also identified and found to contain the binding sequence; one of these has been shown to be functional, while the other has not (36,37).…”

Section: Methodsmentioning

confidence: 99%

Activation Transcription Factor 1 Involvement in the Regulation of Murine H-2D Expression

Ishiguro

Brown

Meruelo

1997

Journal of Biological Chemistry

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Resistance to radiation leukemia virus-induced leukemia is correlated with an increase in H-2D expression on the thymocyte surface. Recently, it has been shown that elevated H-2D d expression on the infected thymocyte is a result of elevated mRNA transcription and that the transcriptional increase is correlated with elevated levels of a DNA binding activity, H-2 binding factor 1 (H-2 BF1), which recognizes the 5 -flanking sequences (5 -TGACGCG-3 ) of the H-2D d gene. This target for transcription factor binding has been found to be identical in the 5 -regulatory region of 12 rodent class I genes, nine of which have been shown to be functional genes. Furthermore, this cis-element is found 5 of 20 primate class I genes (15 human genes), seven of which are known to be functional. Here, we demonstrate that activation transcription factor 1 (ATF-1) is one component of H-2 BF1. In addition, the levels of ATF-1 mRNA in uninfected and radiation leukemia virus-infected thymocytes parallel those of H-2D d mRNA, and therefore, it is suggested that ATF-1 up-regulates the transcription of the H-2D d gene after radiation leukemia virus infection of thymocytes. Transfection experiments also demonstrate that ATF-1 activates a reporter plasmid that contains the H-2 BF1 motif, but not a reporter lacking this motif. This is the first demonstration of the interaction of ATF-1 with 5 -regulatory sequences of major histocompatibility complex class I genes.

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Multiple TL-like loci in the grc-G/C region of the rat

Cited by 18 publications

References 35 publications

?Both man & bird & beast?: comparative organization of MHC genes

?Both man & bird & beast?: comparative organization of MHC genes

Mapping of H2-M homolog and MOG genes in the rat MHC

Activation Transcription Factor 1 Involvement in the Regulation of Murine H-2D Expression

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