Multiple targets of the microRNA miR-8 contribute to immune homeostasis in Drosophila

Lee, Gang Jun; Hyun, Sangwon

doi:10.1016/j.dci.2014.03.015

Cited by 46 publications

(41 citation statements)

References 34 publications

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“…However, the molecular mechanisms behind these processes are still not fully understood. As regulatory elements, miRNAs play critical roles in immune diseases including psoriasis via participating in the development of immune cells, maintaining immune homeostasis, regulating innate and adaptive immunity, as well as regulating inflammatory factors …”

Section: Discussionmentioning

confidence: 99%

MiR‐126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis

Feng

Wang²,

Liu

et al. 2018

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

MiR‐126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis

Feng

Wang²,

Liu

et al. 2018

Clinical Laboratory Analysis

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“…Parasitization affects the miRNA profile of the lepidopteran host, including expression of miR-8, a conserved miRNA that affects antimicrobial peptide production in D. melanogaster [79]. In P. xylostella , miR-8 targets Serpin 27, which regulates the expression of the antimicrobial peptide gloverin [78].…”

Section: Biological Functions Of Arthropod Serpins In Insect Immunitymentioning

confidence: 99%

Serpins in arthropod biology

Meekins

Kanost

Michel

2017

Seminars in Cell & Developmental Biology

144

136

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Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest. Serpins regulate insect innate immunity via inhibition of serine proteinase cascades that initiate immune responses such as melanization and antimicrobial peptide production. In addition, several serpins with anti-pathogen activity are expressed as acute-phase serpins in insects upon infection. Parasitoid wasps can downregulate host serpin expression to modulate the host immune system. In addition, examples of serpin activity in development and reproduction in Drosophila have also been discovered. Serpins also function in host-pathogen interactions beyond immunity as constituents of venom in parasitoid wasps and saliva of blood-feeding ticks and mosquitoes. These serpins have distinct effects on immunosuppression and anticoagulation and are of interest for vaccine development. Lastly, the known structures of arthropod serpins are discussed, which represent the serpin inhibitory mechanism and provide a detailed overview of the process.

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“…For example, in mammals, bacterially induced miRNAs negatively regulate Toll-like receptor (TLR) signaling (Nahid et al, 2011). Several insect miRNAs have previously been shown to negatively regulate innate immune pathways and to determine susceptibility to infection (Choi and Hyun, 2012; Etebari and Asgari, 2013; Hussain et al, 2013; Lee and Hyun, 2014). Most notably, an Ae.…”

Section: 0 Conclusionmentioning

confidence: 99%

“…Recently, a role for miRNAs in insect immunity has been shown in D. melanogaster ; where dme-miR-8 controls basal immune homeostasis (Choi and Hyun, 2012; Lee and Hyun, 2014). This sequence is conserved in the diamondback moth Plutella xylostella and up-regulates the expression of the TOLL pathway negative regulator serpin 27 (Etebari and Asgari, 2013).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota

Dennison

BenMarzouk-Hidalgo

Dimopoulos

2015

Developmental & Comparative Immunology

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Invasion of the malaria vector Anopheles gambiae midgut by Plasmodium parasites triggers transcriptional changes of immune genes that mediate the antiparasitic defense. This response is largely regulated by the Toll and Immune deficiency (IMD) pathways. To determine whether An. gambiae microRNAs (miRNAs) are involved in regulating the anti-Plasmodium defense, we showed that suppression of miRNA biogenesis results in increased resistance to Plasmodium falciparum infection. In silico analysis of An. gambiae immune effector genes identified multiple transcripts with miRNA binding sites. A comparative miRNA microarray abundance analysis of P. falciparum infected and naïve mosquito midgut tissues showed elevated abundance of miRNAs aga-miR-989 and aga-miR-305 in infected midguts. Antagomir inhibition of aga-miR-305 increased resistance to P. falciparum infection and suppressed the midgut microbiota. Conversely, treatment of mosquitoes with an artificial aga-miR-305 mimic increased susceptibility to P. falciparum infection and resulted in expansion of midgut microbiota, suggesting that aga-miR-305 acts as a P. falciparum and gut microbiota agonist by negatively regulating the mosquito immune response. In silico prediction of aga-miR-305 target genes identified several anti-Plasmodium effectors. Our study shows that An. gambiae aga-miR-305 regulates the anti-Plasmodium response and midgut microbiota, likely through post-transcriptional modification of immune effector genes.

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Multiple targets of the microRNA miR-8 contribute to immune homeostasis in Drosophila

Cited by 46 publications

References 34 publications

MiR‐126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis

MiR‐126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells' apoptosis in psoriasis

Serpins in arthropod biology

MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota

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