Multiple System Organ Failure, Intermediate Syndrome, Congenital Myasthenic Syndrome, and Anticholinesterase Treatment: The Linkage is Puzzling

Fe, Leon-S; Pradilla-A, G; Gamboa, N. Castaño; E, Vesga

doi:10.3109/15563659609013779

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Os praguicidas anticolinesterásicos estão associados também à ocorrência de neuropatia periférica tardia (dores musculares, fraqueza muscular progressiva e diminuição dos reflexos tendinosos que ocorrem após duas a três semanas ou até meses após a exposição) e à síndrome intermediária (paralisia da musculatura proximal dos membros, da musculatura flexora do pescoço e da musculatura respiratória que ocorre 24 a 96 horas após a crise colinérgica aguda), alterações bastante descritas para organofosforados e menos freqüentemente para carbamatos (LEON et al, 1996;ANDRADE FILHO & ROMANO, 2001).…”

Section: Diagnóstico Das Intoxicações Por Aldicarbunclassified

Toxicologia do praguicida aldicarb ("chumbinho"): aspectos gerais, clínicos e terapêuticos em cães e gatos

Xavier

Righi

2007

Cienc. Rural

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Section: Diagnóstico Das Intoxicações Por Aldicarbunclassified

Toxicologia do praguicida aldicarb ("chumbinho"): aspectos gerais, clínicos e terapêuticos em cães e gatos

Xavier

Righi

2007

Cienc. Rural

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“…Os praguicidas anticolinesterásicos estão associados também à ocorrência de neuropatia periférica tardia (dores musculares, fraqueza muscular progressiva e diminuição dos reflexos tendinosos que ocorrem após 2 a 3 semanas ou até meses após a exposição) e à síndrome intermediária (paralisia da musculatura proximal dos membros, da musculatura flexora do pescoço e da musculatura respiratória que ocorre 24 a 96 horas após a crise colinérgica aguda), alterações bastante descritas para organofosforados e menos freqüentemente para carbamatos ROMANO, 2001;BURGESS;BERNSTEIN;HURLBUT, 1994;LEON et al, 1996;LOBO JR., 2003). Os carbamatos associados a neuropatia periférica tardia foram o carbaril e o m-tolil metilcarbamato (ALONZO;CORRÊA, 2003).…”

Section: Praguicidas Com Efeito Anticolinesterásico: Carbamatosunclassified

Intoxicação por aldicarb ("chumbinho") em cães e gatos: estudo das alterações post mortem macroscópicas e diagnóstico toxicológico por meio da cromatografia em camada delgada em amostras de conteúdo estomacal

Xavier¹

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XAVIER, F. G. Fatal aldicarb intoxication in dogs and cats: study of post mortem macroscopic alterations and toxicological diagnosis using thin-layer chromatography in samples of stomach content. [Intoxicação por aldicarb ("chumbinho") em cães e gatos: estudo das alterações post mortem macroscópicas e diagnóstico toxicológico por meio da cromatografia em camada delgada em amostras de conteúdo estomacal]. 2004. 191 f.

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“…Transient renal injury is caused by direct action of the organophosphate, causing tubular cell necrosis or secondary mechanism that follows the cholinergic crisis, leading to hypovolemic shock and rhabdomyolysis. 4 Bardin's classification for OPP is convenient to be used for early assessment of OPP and grading may facilitate to recognize seriously poisoned patients for early emergency care. 5 Moreover, laboratory confirmation of the diagnosis may be necessary in order to provide optimal patient care.…”

Section: Introductionmentioning

confidence: 99%

Study of emergency laboratory parameters in acute oraganophosphorus poisoning in a rural population- retrospective study

Chandana¹,

Rasalkar²,

Reddy³

et al. 2020

IJCBR

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Introduction: Organophosphorus poisoning (OPP) is one of the common medical emergencies among rural population in India due to suicide attempts. The purpose of this study was to investigate the relationship between the initial emergency laboratory parameters (electrolytes, liver function test, random blood glucose (RBS), renal function test, Hb, RBC and WBC) and severity of organophosphate poisoning based on Bardin's Classification and type of OP compound consumed in patients admitted to emergency department with OPP. Materials and Methods: A retrospective observational study was done in OPP patients admitted to emergency medicine department. Based on Bardin's classification all OPP cases were classified into 3 Grades of severity of poisoning. [1][2][3] Hematological and biochemical parameters were compared based on this severity of poisoning. Results: With random sampling of 45 patients, 19 male and 26 female patients aged between 25-35 years, admitted with OPP were included in the study. The severity of poisoning was worst in females. The pseudocholinesterase, potassium and creatinine levels were significantly low in patients of grade 3 than grade 1 and grade 2 (p <0.05, 0.05 and 0.02 respectively) poisoning. Liver enzymes (AST, ALT and ALP) were elevated in Grade 3 poisoning patients much higher than Grade 1 and Grade 2 (p value 0.004, 0.002 and 0.06 respectively). Hyperglycemia was significantly observed in Grade 3 poisoning patients at the time of admission. (p value 0.03). There was significant hypokalemia (0.02), low RBC counts (0.02) and pseudocholinesterase levels (p value 0.01) in patients who had consumed chlorpyriphos and phorate. Conclusion: Emergency laboratory parameters in acute oraganophosphorus poisoning reflect the need for basic diagnostic facility in rural area. Laboratory parameters can also serve as possible predictive markers for severe outcomes and prognosis in OP poisoning. The knowledge of type of OP compound consumed can predict the severity of OP intoxication and need for emergency intervention.

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Multiple System Organ Failure, Intermediate Syndrome, Congenital Myasthenic Syndrome, and Anticholinesterase Treatment: The Linkage is Puzzling

Cited by 9 publications

References 7 publications

Toxicologia do praguicida aldicarb ("chumbinho"): aspectos gerais, clínicos e terapêuticos em cães e gatos

Toxicologia do praguicida aldicarb ("chumbinho"): aspectos gerais, clínicos e terapêuticos em cães e gatos

Intoxicação por aldicarb ("chumbinho") em cães e gatos: estudo das alterações post mortem macroscópicas e diagnóstico toxicológico por meio da cromatografia em camada delgada em amostras de conteúdo estomacal

Study of emergency laboratory parameters in acute oraganophosphorus poisoning in a rural population- retrospective study

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