Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder

Chang, Hsi; Tsai, Chung Min; Hou, Chun Yin; Tseng, Sung Hui; Lee, Ju Chin; Tsai, Meng‐Li

doi:10.1016/j.jfma.2018.08.007

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…A recently published study by Chang et al extended the period of neurodevelopment follow-up to 83 months. 1 They found that multiple subependymal pseudocysts in normal-term neonates were a risk factor for abnormal neurobehavioral outcomes, particularly in ADHD and ASD. In our study, children were diagnosed with ADHD or cognition delay/learning difficulties during preschool years.…”

Section: Discussionmentioning

confidence: 99%

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Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Lin

Chiu

Chen

et al. 2021

Pediatrics & Neonatology

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Background: To analyze the findings of cranial ultrasonographic screening in asymptomatic neonates and to assess the association between abnormal results and neurodevelopment. Methods: We retrospectively reviewed the cranial ultrasonographic screening results of healthy neonates born between 35 and 42 weeks gestation at our hospital from October 2011 to October 2018. Results: In total, 11,681 neonates underwent cranial ultrasonographic screening during the study period, and 9666 (82.7%) had normal results. Of 2015 neonates with abnormal findings, 294 had more than two abnormalities. The most common minor findings were subependymal cysts (8.99%), choroid plexus cysts (2.43%), lenticulostriate vasculopathy (2.34%), frontal horn cysts (1.80%), and enlarged cisterna magna (1.04%). Then, 33 (0.28%) neonates had major abnormalities, including cerebral hemorrhage, periventricular heterotopia, focal cortical dysplasia, anomalies of the corpus callosum, and vascular malformation. Of 1334 neonates who underwent serial clinical evaluations, 76 (5.69%) had neurodevelopmental disorders, including developmental delay, attention-deficit/hyperactivity disorder, and autistic spectrum disorder. Conclusion: The incidence rate of intracranial anomalies in healthy neonates was 17.3%, and about 5.69% had neurodevelopmental disorders. Cranial ultrasonographic screening has its own value in helping early detection of intracranial anomalies in healthy neonates, some of which have prognostic implications.

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Section: Discussionmentioning

confidence: 99%

“…Even minor findings have been associated with developmental delays, attention-deficit/hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD). 1 Neonatal CUS may facilitate the early identification of these problems. In Taiwan, CUS screening has been performed for several years.…”

Section: Introductionmentioning

confidence: 99%

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Lin

Chiu

Chen

et al. 2021

Pediatrics & Neonatology

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“…Dysfunction of the pineal gland is also related to abnormal metabolism of N-dimethyltryptamine, which could explain the abnormal neuroplasticity and neuronal distribution that are present in some cases of autism (Bedford et al, 2016). Subependymal cysts were found to be closely associated with developmental delay and developmental disability, ADHD and ASD in particular, while the higher the extent of subependymal cysts, the higher the risk of neurodevelopmental delay (Chang et al, 2018). The pathogenesis of subependymal cysts in the lateral ventricles is unclear, but histological studies identified macrophages lining the cysts, which indicates preexisting malacia caused by old hemorrhage, hypoxia, metabolic disease, and viral infection insults of the germinal matrix (Malinger et al, 2002;Shaw and Alvord, 1974).…”

Section: Discussionmentioning

confidence: 99%

The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Efremova¹,

Lisý²,

Hrdlička³

2021

JAB

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The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology.A retrospective analysis covering a period between 1998 and 2015 included 489 children with autism (404 boys, 85 girls; average age 8.0 ± 4.2 years) who underwent an MRI of the brain. For clinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview -Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables.The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002).Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.

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“…In a large sample of neonates receiving cranial ultrasound testing one week after birth, these patients were prospectively followed and received repeated neurodevelopmental assessments between the ages of 5 and 15. The authors found that while CP and frontal horn cysts were not associated with autism risk, subependymal cysts were associated with developmental delay in 5.5% of children and the odds ratios for developing autistic spectrum disorder was 28.54 [ 112 ]. In a large retrospective study of autism and neurotypical patients, the authors identified increased ventricular volumes among patients with autism and extended these findings to the CP [ 113 ].…”

Section: The Neuropathological Role Of the Choroid Plexus In Neuropsy...mentioning

confidence: 99%

Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders

2022

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The choroid plexus (CP) is a delicate and highly vascularized structure in the brain comprised of a dense network of fenestrated capillary loops that help in the synthesis, secretion and circulation of cerebrospinal fluid (CSF). This unique neuroanatomical structure is comprised of arachnoid villi stemming from frond-like surface projections—that protrude into the lumen of the four cerebral ventricles—providing a key source of nutrients to the brain parenchyma in addition to serving as a ‘sink’ for central nervous system metabolic waste. In fact, the functions of the CP are often described as being analogous to those of the liver and kidney. Beyond forming a barrier/interface between the blood and CSF compartments, the CP has been identified as a modulator of leukocyte trafficking, inflammation, cognition, circadian rhythm and the gut brain-axis. In recent years, advances in molecular biology techniques and neuroimaging along with the use of sophisticated animal models have played an integral role in shaping our understanding of how the CP–CSF system changes in relation to the maturation of neural circuits during critical periods of brain development. In this article we provide an ontogenetic perspective of the CP and review the experimental evidence implicating this structure in the pathophysiology of neurodevelopmental and neuropsychiatric disorders.

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Multiple subependymal pseudocysts in neonates play a role in later attention deficit hyperactivity and autistic spectrum disorder

Abstract: Our data revealed multiple SEPCs in normal-term neonates as a risk factor for neurobehavioral outcome, particularly in ADHD and ASD. Simultaneously, the utility of CUS examination as a health examination item for neonates was confirmed.

Cited by 9 publications

References 21 publications

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders

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