Multiple strategies with the synergistic approach for addressing colorectal cancer

Karthika, Chenmala; Balaji, Hari; Rahman, Md. Habibur; Akter, Rokeya; Najda, Agnieszka; Albadrani, Ghadeer M.; Sayed, Amany A.; Akhtar, Muhammad Furqan; Abdel-Daim, Mohamed M.

doi:10.1016/j.biopha.2021.111704

Cited by 28 publications

(21 citation statements)

References 111 publications

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“…Lately, scientists have found on comparing adenomatosis polyposis coli tumor suppressor (APC) genes in healthy and colon cancer suffering cells on later consists of transposes. This further testifies the fact that transposes in somatic cells in mammals have some role in the development of colorectal cancer (Miki et al 1992;Chenmala et al 2021). Viruses are a common infectious agent that can induce mutagenesis as they can insert their DNA into the host genome and disrupt the gene functionality.…”

Section: Infectious Agents Mediated Mutagenesismentioning

confidence: 67%

Unboxing the molecular modalities of mutagens in cancer

Kumari

Sharma

Advani

et al. 2021

Environ Sci Pollut Res

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Graphical abstract The etiology of the majority of human cancers is associated with a myriad of environmental causes, including physical, chemical, and biological factors. DNA damage induced by such mutagens is the initial step in the process of carcinogenesis resulting in the accumulation of mutations. Mutational events are considered the major triggers for introducing genetic and epigenetic insults such as DNA crosslinks, single- and double-strand DNA breaks, formation of DNA adducts, mismatched bases, modification in histones, DNA methylation, and microRNA alterations. However, DNA repair mechanisms are devoted to protect the DNA to ensure genetic stability, any aberrations in these calibrated mechanisms provoke cancer occurrence. Comprehensive knowledge of the type of mutagens and carcinogens and the influence of these agents in DNA damage and cancer induction is crucial to develop rational anticancer strategies. This review delineated the molecular mechanism of DNA damage and the repair pathways to provide a deep understanding of the molecular basis of mutagenicity and carcinogenicity. A relationship between DNA adduct formation and cancer incidence has also been summarized. The mechanistic basis of inflammatory response and oxidative damage triggered by mutagens in tumorigenesis has also been highlighted. We elucidated the interesting interplay between DNA damage response and immune system mechanisms. We addressed the current understanding of DNA repair targeted therapies and DNA damaging chemotherapeutic agents for cancer treatment and discussed how antiviral agents, anti-inflammatory drugs, and immunotherapeutic agents combined with traditional approaches lay the foundations for future cancer therapies.

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Section: Infectious Agents Mediated Mutagenesismentioning

confidence: 67%

Unboxing the molecular modalities of mutagens in cancer

Kumari

Sharma

Advani

et al. 2021

Environ Sci Pollut Res

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“…The worldwide incidence of BC in 2012 was 1.67 million, which is alarming [3]. The incidence may increase to 3.2 million by 2050 [4,5]. Males may also develop BC, but this is very rare, accounting for <1% of diagnosed BCs worldwide [6].…”

Section: Introductionmentioning

confidence: 99%

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

et al. 2021

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Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.

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“…Therefore, it is essential to develop effective multifunctional 5-FU nanocarriers to improve targeted delivery, resulting in improved anticancer treatments. The following nanocarriers of 5-FU were proposed: polymer-based carriers such as chitosan beads, Eudragit ® , Poly(alkylcyanoacrylates), PLGA, β-cyclodextrin as well as liposomes, nanoemulsions, solid lipid nanoparticles, gold nanoparticles, silica nanocarriers, iron oxides nanoparticles, graphene oxides, and QD [24][25][26][27][28][29][30][31][32][33][34][35] The present contribution aimed to develop a novel method of preparing multifunctional 5-FU nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by the encapsulation of drug-loaded nanocores with polyaminoacids multilayer shell via the layer-by-layer method with saturation technique.…”

Section: Introductionmentioning

confidence: 99%

“…5-FU is an analog of uracil with a fluorine atom at the C-5 position in place of hydrogen [ 19 , 20 ]. The mechanism of action of 5-FU is related to inhibiting nucleoside metabolism and DNA synthesis [ 20 , 22 , 23 , 24 ]. Nevertheless, clinical use of 5-FU is limited due to a short half-life, systemic toxicity, and non-selective delivery [ 23 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

Szczęch

Hinz

Łopuszyńska

et al. 2021

IJMS

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Cancer is one of the most important health problems of our population, and one of the common anticancer treatments is chemotherapy. The disadvantages of chemotherapy are related to the drug’s toxic effects, which act on cancer cells and the healthy part of the body. The solution of the problem is drug encapsulation and drug targeting. The present study aimed to develop a novel method of preparing multifunctional 5-Fluorouracil (5-FU) nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by encapsulation drug-loaded nanocores with polyaminoacids multilayer shell via layer-by-layer method. The size of prepared nanocarriers ranged between 80–200 nm. Biocompatibility of our nanocarriers as well as activity of the encapsulated drug were confirmed by MTT tests. Moreover, the ability to the real-time observation of developed nanocarriers and drug accumulation inside the target was confirmed by fluorine magnetic resonance imaging (19F-MRI).

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Multiple strategies with the synergistic approach for addressing colorectal cancer

Cited by 28 publications

References 111 publications

Unboxing the molecular modalities of mutagens in cancer

Unboxing the molecular modalities of mutagens in cancer

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

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