We aim to generalize the (2+1)-dimensional Hirota-Satsuma-Ito (HSI) equation, passing the three-soliton test, to a new one which still has diverse solution structures. We add all second-order derivative terms to the HSI equation but demand the existence of lump solutions. Such lump solutions are formulated in terms of the coefficients, except two, in the resulting generalized HSI equation. As an illustrative example, a special completely generalized HSI equation is given, together with a lump solution, and three 3d-plots and contour plots of the lump solution are made to elucidate the characteristics of the presented lump solutions.