Multiple Sklerose: Neurorehabilitation und symptomatische Therapie

Sailer, Michael; Lindquist, Sabine; Sickert, Almut; Lamprecht, J.

doi:10.1055/a-0755-1398

Cited by 2 publications

(2 citation statements)

References 15 publications

(8 reference statements)

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“…Figure 1 summarizes the treatment modalities for the tremor in MS. Isoniazid, one of the first-line anti-tubercular agents, has shown promising results in a few randomized controlled trials in MS-related tremors (Figure 1) [39][40][41][42][43][44][45]. However, several adverse effects have limited its use [39][40][41][42].…”

Section: ) Tremormentioning

confidence: 99%

Movement Disorders in Multiple Sclerosis: An Update

Ghosh

Roy

Dubey

et al. 2022

Tremor and Other Hyperkinetic Movements

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Background: Multiple sclerosis (MS), a subset of chronic primary inflammatory demyelinating disorders of the central nervous system, is closely associated with various movement disorders. These disorders may be due to MS pathophysiology or be coincidental. This review describes the full spectrum of movement disorders in MS with their possible mechanistic pathways and therapeutic modalities. Methods:The authors conducted a narrative literature review by searching for 'multiple sclerosis' and the specific movement disorder on PubMed until October 2021. Relevant articles were screened, selected, and included in the review according to groups of movement disorders. Results:The most prevalent movement disorders described in MS include restless leg syndrome, tremor, ataxia, parkinsonism, paroxysmal dyskinesias, chorea and ballism, facial myokymia, including hemifacial spasm and spastic paretic hemifacial contracture, tics, and tourettism. The anatomical basis of some of these disorders is poorly understood; however, the link between them and MS is supported by clinical and neuroimaging evidence. Treatment options are disorder-specific and often multidisciplinary, including pharmacological, surgical, and physical therapies.Discussion: Movements disorders in MS involve multiple pathophysiological processes and anatomical pathways. Since these disorders can be the presenting symptoms, they may aid in early diagnosis and managing the patient, including monitoring disease progression. Treatment of these disorders is a challenge. Further work needs to be done to understand the prevalence and the pathophysiological mechanisms responsible for movement disorders in MS.

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Section: ) Tremormentioning

confidence: 99%

Movement Disorders in Multiple Sclerosis: An Update

Ghosh

Roy

Dubey

et al. 2022

Tremor and Other Hyperkinetic Movements

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show abstract

“…In patients with MS, functional mobility alterations can interfere with participation, activities of daily living, employment, and quality of life 16,17 . According to Sailer and colleagues (2019) 18 , these aspects collaborate to MS being considered the most common cause of disability in young adults.…”

Section: Introductionmentioning

confidence: 97%

Correlation of Lower Limb Muscle Strength with Functional Mobility and Quality of Life in Patients with Multiple Sclerosis

Fraga¹,

Rodrigues

Catarino³

2022

MRAJ

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Introduction: Multiple sclerosis (MS) generates physical deficits such as muscle weakness of the lower limbs and reduced functional mobility, thus presenting a decline in the patients' quality of life. Objective: Correlate the muscle strength of lower limbs with functional mobility and quality of life in patients with multiple sclerosis. Methodology: Correlational, ex post facto retrospective study. Data from 49 patients with multiple sclerosis were used, chosen from an existing database of the Neurofunctional Physiotherapy Outpatient Clinic of the Hospital de Clínicas de Porto Alegre. The tests analyzed for the study were: The 5-repetition sit-to-stand (STS) test (5STS - lower limb muscle strength) and Timed up And Go (TUG - functional mobility), in addition to the Multiple Sclerosis Impact Scale (MSIS-29 - quality of life) in individuals with MS. Results: The average time that patients performed the 5STS was 15.39 (± 8.65) seconds. In the TUG, the average was 11.50 (± 8.40) seconds. Regarding the MSIS-29 scale, the percentage in the physical domain was 37.83% (± 25.10%) and in the psychological domain 45.18% (± 28.92%). A positive correlation was found between the time to perform the 5STS test and the time to perform the TUG (r=,566 p<,000). A positive correlation was also found between 5STS and the physical domain of MSIS-29 (r=,351 p<,0014). Conclusion: The greater the muscular strength of the lower limbs, the greater the functional mobility and the quality of life in the physical environment of these patients.

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Multiple Sklerose: Neurorehabilitation und symptomatische Therapie

Cited by 2 publications

References 15 publications

Movement Disorders in Multiple Sclerosis: An Update

Movement Disorders in Multiple Sclerosis: An Update

Correlation of Lower Limb Muscle Strength with Functional Mobility and Quality of Life in Patients with Multiple Sclerosis

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