Multiple single units and population responses during inhibitory gating of hippocampal auditory response in freely-moving rats

Moxon, Karen A.; Gerhardt, Greg A.; Bickford, Paula C.; Austin, Kevin; Rose, Gregory M.; Woodward, Donald J.; Adler, Lawrence E.

doi:10.1016/s0006-8993(99)01187-7

Cited by 75 publications

(62 citation statements)

References 27 publications

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“…Consistent with this idea, some PPTg cells in cat were found to respond to conditioned stimuli in a context-dependent way, failing to respond to the same cue when another signal indicated a different task requirement (Dormont et al, 1998). However, these data are difficult to interpret, because there were multiple sequential sensory cues, which may have triggered prepulse inhibition of later responses (Bickford et al, 1993;Moxon et al, 1999).…”

Section: Discussionmentioning

confidence: 87%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

182

170

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Midbrain dopamine (DA) neurons respond to sensory cues that predict reward. We tested the hypothesis that projections from the pedunculopontine tegmental nucleus (PPTg) are involved in driving this DA cell activity. First, the activity of PPTg and DA neurons was compared in a cued-reward associative learning paradigm. The majority of PPTg neurons showed phasic responses to the onset of sensory cues, at significantly shorter latency than DA cells, consistent with a PPTg-to-DA transmission of information. However, unlike DA cells, PPTg responses were almost entirely independent of whether signals were associated with rewards. Second, DA neuron responses to the cues were recorded in free-moving rats during reversible inactivation of the PPTg by microinfusion of local anesthetic. The results showed clear suppression of conditioned sensory responses of DA neurons after PPTg inactivation that was not seen after saline infusion or in non-DA cells. We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons.

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Section: Discussionmentioning

confidence: 87%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

182

170

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“…Filtering of repetitive auditory stimulation has also been observed in the pontine reticular formation (PRF) (Bickford et al, 1993;Moxon et al, 1999), in the medial septum (Moxon et al, 1999), in the reticular thalamic nucleus (RTN) (Krause et al, 2003) and in the amygdala (Cromwell et al, 2005). In addition, hippocampal auditory gating is influenced by stimulation of both the PRF and nucleus of the lateral lemniscus (NLL) (Bickford et al, 1993).…”

Section: Compensatory Changesmentioning

confidence: 99%

Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice

et al. 2008

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The α7 subtype of nicotinic receptor is highly expressed in the hippocampus where it is purported to modulate release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The α7 receptormediated release of GABA is thought to contribute to hippocampal inhibition (gating) of response to repetitive auditory stimulation. This hypothesis is supported by observations of hippocampal auditory gating deficits in mouse strains with low levels of hippocampal α7 receptors compared to strains with high levels of hippocampal α7 receptors. The difficulty with comparisons between mouse strains, however, is that different strains have different genetic backgrounds. Thus, the observed interstrain differences in hippocampal auditory gating might result from factors other than interstrain variations in the density of hippocampal α7 receptors. To address this issue, hippocampal binding of the α7 receptor-selective antagonist α-bungarotoxin as well as hippocampal auditory gating characteristics were compared in C3H wild type and C3H α7 receptor null mutant heterozygous mice. The C3H α7 heterozygous mice exhibited significant reductions in hippocampal α7 receptors levels and abnormal hippocampal auditory gating compared to the C3H wild type mice. In addition, a general increase in CA3 pyramidal neuron responsivity was observed in the heterozygous mice compared to the wild type mice. These data suggest that decreasing hippocampal α7 receptor density results in a profound alteration in hippocampal circuit function.

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“…The results simulating these models were compared to the response characteristices of CA3 cells recorded during the P50 auditory gating paradigm to determine which model best simulated the data. These data from animal studies (Moxon et al 1999) revealed two characteristics of the response properties of CA3 hippocampal cells to the auditory click stimuli. First, less than 15% of the cells responded to the first or conditioning click.…”

Section: Representation Of Information In the Modelmentioning

confidence: 89%

“…The first characteristic was that less than 15% of the cells responded to the conditioning click stimulus. The second important phenomenon was that, when individual trials were examined, cells that that were found to have responded to the test click were also found to have responded to the conditioning, or first, click (Moxon et al 1999). These data suggested that certain cells are set to respond to the click stimulus while others are not and that during the test click the response of many of these cells is inhibited.…”

Section: Model Hypothesismentioning

confidence: 99%

“…The evoked potentials were modeled by simulating experimental data collected from rats during the presentation of paired auditory clicks that measured the firing rates of septal, hippocampal, and EC cells (Moxon et al 1999). Using these data, we simulated the click stimuli by increasing the septal cholinergic input and the cortical input in the following manner.…”

Section: Simulation Of Evoked Potentialsmentioning

confidence: 99%

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Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus

Moxon

Gerhardt

Gulinello

et al. 2003

Biological Cybernetics

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A model of the CA3 region of the hippocampus was used to simulate the P50 auditory-evoked potential response to repeated stimuli in order to study the neuronal circuits involved in a sensoryprocessing deficit associated with schizophrenia. Normal subjects have a reduced P50 auditoryevoked potential amplitude in response to the second of two paired auditory click stimuli spaced 0.5 s apart. However, schizophrenic patients do not gate or reduce their response to the second click. They have equal auditory-evoked response amplitudes to both clicks. When schizophrenic patients were medicated with traditional neuroleptics, the evoked potential amplitude to both clicks increased, but gating of the second response was not restored or improved. Animal studies suggest a role for septohippocampal cholinergic activity in sensory gating. We used a computational model of this system in order to study the relative contributions of local processing and afferent activity in sensory gating. We first compared the effect of information representation as average firing rate to information representation as cell assemblies in order to evaluate the best method to represent the response of hippocampal neurons to the auditory click. We then studied the effects of nicotinic cholinergic input on the response of the network and the effect of GABA B receptor activation on the ability of the local network to suppress the test response. The results of our model showed that nicotinic cholinergic input from the septum to the hippocampus can control the flow of sensory information from the cortex into the hippocampus. In addition, postsynaptic GABA B receptor activation was not sufficient to suppress the test response when the interstimulus interval was 500 ms. However, presynaptic GABA B receptor activity may be responsible for the suppression of the test response at this interstimulus interval.

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Multiple single units and population responses during inhibitory gating of hippocampal auditory response in freely-moving rats

Cited by 75 publications

References 27 publications

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Altered hippocampal circuit function in C3H α7 null mutant heterozygous mice

Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus

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