Multiple Self-Healing Epithelioma of Ferguson Smith Type

Rook, Arthur

doi:10.1001/archderm.1956.01550110069015

Cited by 24 publications

(2 citation statements)

References 11 publications

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“…We concur with the opinion of Rook and Moffat [13] th at cases " described by Witten and Zak [14], and by Grzybowsky [15] (in which lesions on oral mucosa were also present) are sufficiently distinctive to w arrant their provisional exclusion from this discussion" .…”

supporting

confidence: 84%

Keratoacanthoma

Stevanović¹

1960

Dermatology

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supporting

confidence: 84%

Keratoacanthoma

Stevanović¹

1960

Dermatology

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“…Although usually solitary, occasionally a few lesions appear. There are a few recognized variant patterns: (1) KA dyskeratoticum and segregans, when several nodules coalesce to form a large plaque [2]; (2) KA centrifigum marginatum, when this cutaneous tumor exhibits peripheral growth up to 20 cm with concurrent central healing [3]; (3) giant KA, when the neoplasm grows over 3 cm in diameter [4]; (4) subungual KA, which may be persistent and destructive [5]; (5) intra oral KA [6]; (6) multiple KAs, when a moderate number of KAs suddenly present, slowly involute and periodically reappear for many years [7]; (7) generaliz ed eruptive KAs, when literally thousands of tiny 2-3 mm KAs are scattered over the patient [8]; (8) KA development in a nevus sebaceous [9]; (9) KA development as part of a generalized eruptive condition either in association with sebaceous neo plasms and an underlying low-grade visceral cancer (the Torre syndrome) [10] or in association with florid cutaneous papillomatosis and an underlying can cer [11].…”

Section: Discussionmentioning

confidence: 99%

Multiple Persistent Keratoacanthomas

Schwartz¹

1979

Oncology

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The etiology of keratoacanthoma

Ghadially

Barton

Kerridge

1963

Cancer

122

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R that keratoacanthomas can be produced in the rabbit,l5 rat,1* hamster,lG mouse,16 hedgehog:' and chicken80 by the application of chemical carcinogens and that these tumors arise from the hair follicles.1* The keratoacanthoma is a common cutaneous tumor in man, but little is known about the etiological factors involved in its production, Familial, viral, and actinic factors have been incriminated as operative in certain cases: while the Occurrence of these tumors in pitch and tar workers and the results of work with experimental animals indicate that chemical carcinogens may play a part in the production of this lesion in man.16We have studied 238 cases of keratoacanthomas treated at the Sheffield Royal Infirmary, Sheffield, England, over a period of 6 years. T h e purpose of this paper is to report the results of this study and tu present our assessment of the extent to which our observations correspond with the concept that chemical carcinogens may be involved in the production of this tumor in man. Also, whether the mechanisms involved are similar to those known to operate in experimental animals is discussed. MATERIALS AND METHODSThis histology files of the Pathology Department and case notes of the Skin Department were used in this survey. All available hist* logical material from skin tumors diagnosed as keratoacanthoma, papilloma, and squamous carcinoma over a period of 6 years (1 954-1 959) was re-examined. The case notes furnished the ages and addresses of the patients and the sites at which the tumor occurred. Question-TABLE 1 ANNUAL INCIDENCE OF KERATO-ACANTHOMAS DURING THE PERIOD 1954-1959 Year No. cases 1954 47 1955 ~. .. 1956 1957 1958 1959 25 29 44 34 59 -TOTAL 238naires asking details of past and present occupations; contact with pitch, tar, coal, and machine oils; smoking habits; and family history of the same condition were sent to patients who had presented with keratoacanthoma.The main aim of the questionnaire was to determine whether the patients had been in contact with known carcinogenic agents. With this in view, they were asked to give details of their past and present occupations. They were also asked whether they had been in contact with tar, pitch, coal, or machine oil. Although coal does not contain a known carcinogenic agent, it was included as a control to test the reliability of answers obtained for known carcinogenic substances such as pitch and tar. Details of smoking history were asked because it seemed likely that the skin of the face and hands of the smoker might be affected by the carcinogenic agents from cigarette smoke. In the questionnaire we also tried to determine if hereditary factors might be involved in the production of the tumor. With this in view we enquired whether any member of the family had developed similar lumps. The effect of environmental factors was further investigated by asking whether friends or neighbors had developed similar tumors.tending the Skin Department of the Infirmary, was selected over a period of several months. The method of selection was ...

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Multiple Self-Healing Epithelioma of Ferguson Smith Type

Cited by 24 publications

References 11 publications

Keratoacanthoma

Keratoacanthoma

Multiple Persistent Keratoacanthomas

The etiology of keratoacanthoma

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