Multiple sclerosis-related fatigue and possibilities of its correction

Лащ, Н. Ю.; Бойко, А. Н.

doi:10.14412/2074-2711-2016-1-82-85

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Патогенез утомляемости при рассеянном склерозе до настоящего время является предметом многочисленных исследований. Утомляемость при РС не имеет прямой связи с выраженностью парезов, однако у пациентов с пирамидной недостаточностью встречается чаще [23]. Учитывая, что скорлупа, входящая в состав лентикулярного ядра, является основной «моторной» структурой полосатого тела [20], полученные нами данные могут объяснить более частые наблюдения повышенной утомляемости у пациентов с пирамидной недостаточностью.…”

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Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis

et al. 2020

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Background. Neurodegenerative processes play an important role in the development of clinical features of multiple sclerosis (MS) as well as in the progression of the disease. At the same time, neurodegenerative mechanisms of MS are not completely clear, which makes researchers pay special attention to pathogenetic aspects of the disease that have not been studied before. Previously it was shown that MS patients can have alterations in the local cerebral blood flow, however, the meaning of the detected abnormalities is still not clear.The aim of our work is to evaluate the perfusion character in the demyelinating lesions and normalappearing brain structures, and to determine their relation to clinical features of MS.Material and methods. 49 patients with relapsing-remitting and secondary progressive MS with clinical and MRI remission were included in the study. The patients underwent contrast-enhanced MR perfusion of the brain on the 3 Tesla MR-tomograph, as well as the Functional System Score, Expanded Disability Status Score and Fatigue Status Score evaluation. The data analysis included automatic construction of perfusion maps of the cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT) values in the normal-appearing brain structures and in the demyelinating lesions and statistical analysis.Results. The received results allow to presume that variation of CBV values in MS lesions can indicate heterogeneity of processes in these lesions – from reactivation of inflammation to remyelination.Significant reduction of perfusion in nucleus lenticularis was revealed. This reduction did not depend on the severity of the disease and correlated negatively with the fatigue score. This allows to suppose that the therapy focused on brain perfusion improvement can be used as symptomatic therapy of MS. Considering the fact that regional hypoperfusion precedes the development of brain structure atrophy, it is hypothesized that the improvement of perfusion may prevent neurodegeneration in MS. The obtained findings need further investigation.

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Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis

et al. 2020

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Clinical markers for unfavorable course of multiple sclerosis

Matrosova,

Belskaya,

Bryukhov

et al. 2023

Annals of Clinical and Experimental Neurology

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Objective. To study possible clinical markers associated with the unfavorable course of multiple sclerosis and its transition to a progressive subtype. Materials and methods. This prospective study included healthy volunteers and patients with relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), primary progressive multiple sclerosis (PPMS). For a comprehensive clinical evaluation, the participants completed the Timed 25-Foot Walk Test (T25-FW), Nine-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Fatigue test, and MSProDiscuss questionnaires. Then we compared the results between the groups. Results. We found significant differences between the groups in regard to most of the tests. Furthermore, we proposed a composite clinical score (CCS) based on T25-FW, SDMT, and 9-HPT results (for both hands). Discussion. Our CCS can be a useful clinical tool to determine the most likely course of multiple sclerosis at a certain timepoint.

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Multiple sclerosis-related fatigue and possibilities of its correction

Cited by 2 publications

References 10 publications

Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis

Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis

Clinical markers for unfavorable course of multiple sclerosis

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