Multiple Sclerosis multimodal lesion simulation tool (MS-MIST)

Abstract

Background: Multiple Sclerosis (MS) diagnosis and evaluation is often a challenging task due to its growing need for multimodal MRI acquisition protocol. Recently, the scientific community offers several computational alternatives to the time-consuming and subjective task of manual MS lesion segmentation. Although there is an increasing number of MS lesion segmentation methods, a controlled and realistic simulation environment can benefit the community for a reliable evaluation procedure. Methods: This study proposes an automatic parametric MS lesion simulation framework (MS-MIST) with the objective to emulate real MS-like pattern on MRI data of healthy individuals. The voxel graylevel patterns, spatial location, and shapes extracted from MS patient allow consistent simulation features. We used both visual evaluation from an expert radiologist in the field of MS diagnosis and SPM Lesion Segmentation Tool (LST) for qualitative and quantitative simulation quality, respectively. Results: Our results show that both the agreement between the automatic segmentation with the simulated lesions (Pearson's correlation R=0.977) and the segmentation quality scores, i.e., sensitivity (mean=0.9050), specificity (mean=0.9992), dice similarity (mean=0.8972), and accuracy (mean=0.9984), are consistent between MS-MIST and real clinical settings. Conclusions: MS-MIST proposes a practical solution to common issues discussed in the literature, such as inconsistency with real lesions geometry, imprecise lesion spatial and signal variability, lack of multiple MRI modalities and restrictions to simulate different lesion loads. It is worth noting that the simulation platform is freely available as an open-source code to the community.

Introducing radiomics model to predict active plaque in multiple sclerosis patients using magnetic resonance images

“…Magnetic resonance imaging (MRI) of the brain and spine is a primary paraclinical imaging modality for the diagnosis and longitudinal evaluation of disease progression. In fact, since the MRI provides high quality images of soft tissues of the human body, this imaging technique is increasingly used in research and clinical fields of MS [11] and consider as the gold standard in the diagnosis of MS plaques in the clinic. It may clearly shows areas of demyelination (lesions or plaques) [12][13][14][15][16].…”