Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims

Wnuk, Marcin; Maluchnik, Michał; Perwieniec, Jakub; Podwójcic, Krzysztof; Szeląg, Mateusz; Walkiewicz, Dorota; Zakrzewski, Michał; Kułakowska, Alina; Brola, Waldemar; Rejdak, Konrad; Słowik, Agnieszka

doi:10.1016/j.msard.2021.103162

Cited by 14 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors decided to deal with this topic due to the lack of epidemiological data regarding NMOSD on the Polish population as well as smaller, local data. Among the available epidemiological data concerning demyelinating disorders in the Polish population, data collected from administrative health claims concerning MS incidence and prevalence in adults [46] and children [47] can be found and agree with numbers shown for central European countries.…”

Section: Demographysupporting

confidence: 81%

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

et al. 2022

Self Cite

View full text Add to dashboard Cite

(1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or misdiagnosis. The aim of the study was to assess factors influencing the underdiagnosis of neuromyelitis optica spectrum disorder (NMOSD) as well as to estimate NMOSD epidemiology in Lubelskie voivodeship, Poland. (2) Methods: This retrospective study included 1112 patients, who were made a tentative or an established diagnosis of acute or subacute onset of neurological deficits. The evaluation was based on medical history, neurological examination, laboratory and radiographic results and fulfilment of diagnosis criteria. (3) Results: Up to 1.62 percent of patients diagnosed with white matter lesions and up to 2.2% of the patients previously diagnosed with MS may suffer from NMOSD. The duration of delayed diagnosis is longer for males, despite the earlier age of onset. Seropositive cases for antibodies against aquaporin-4 have worse prognosis for degree of disability. (4) Conclusions: Underdiagnosis or misdiagnosis in NMOSD still remains a problem in clinical practice and has important implications for patients. The incorrect diagnosis is caused by atypical presentation or NMOSD-mimics; however, covariates such as gender, onset and diagnosis age may also have an influence.

show abstract

Section: Demographysupporting

confidence: 81%

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Such information availability makes it difficult, among other things, to determine the precise moment of an MS disease episode. It was recently analysed in detail and different algorithms have been tested for obtaining epidemiological data for Poland [21]. One possible effect of a limited data scope is that 23.82% of MS cases (patients confirmed to have multiple sclerosis during their first visits in 2016) were identified in patients over 50 years of age, while it is believed that there should be notably fewer of such patients.…”

Section: Study Limitationsmentioning

confidence: 99%

Gender-Related Differences in Prodromal Multiple Sclerosis Characteristics: A 7-Year Observation Study

Perwieniec

Podwójcic

Maluchnik

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

Increasing evidence supports the observation that multiple sclerosis (MS) has a preclinical period, with various prodromal signs and symptoms more frequently represented in patients with confirmed MS many years later. Considering the apparent gender differences in the incidence and clinical course of MS, it remains unclear whether it could be reflected in prodromal symptom features. This study aimed to compare a broad spectrum of prodromal signs and symptoms between males and females in the 7-year period before the definite diagnosis of MS. Data came from the central register of the national payer of services, financed under the public healthcare system in Poland. They covered a 7-year period of patient health record claims, from 2009 to 2016. The following groups of symptoms were significant with women: musculoskeletal (p < 0.001), ophthalmic (p < 0.001), laryngological (p < 0.001), digestive system (p < 0.001), urinary tract (p < 0.001), mental (p < 0.001), cardiovascular (p < 0.001), complaints and headaches (p < 0.001). There was also a weak correlation with head injuries (p = 0.03) while dermatological and reproductive system complaints did not appear to be significant (p < 0.05). For males, the following groups of symptoms were significant: musculoskeletal (p < 0.001), ophthalmic (p < 0.001), laryngological (p = 0.007), cardiovascular system symptoms (p < 0.001), and headaches (p < 0.001). Interestingly, reproductive system problems were overrepresented in the male population (p = 0.008). There was no significant correlation with MS risk for dermatological, digestive, urinary, and mental complaints. Similarly, head injuries were not significant. Our results shed more light on well-known differences in the epidemiological and clinical characteristics between sexes in multiple sclerosis, and show differences in prodromal complaints before MS onset.

show abstract

“…In Poland, monitoring of the epidemiological situation with regard to MS has only been recently initiated [13]. Studies carried out in recent years have indicated the prevalence in adults as approximately 131/100,000 and the incidence to be 6.6/100,000 person-years [14]. It has been estimated that approximately 50,000 individuals suffer from the disease in Poland.…”

Section: Discussionmentioning

confidence: 99%

“…In our own study, the average age of incidence was 14.8 years (range [5][6][7][8][9][10][11][12][13][14][15][16][17][18], and MS at the age of <12 years was more than five times less frequent than between 13 and 18 years of age.…”

Section: Discussionmentioning

confidence: 99%

The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland

Brola

Steinborn

Žák

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

Background. Paediatric-onset MS (POMS) has a unique clinical profile compared to the more prevalent adult-onset MS. For this study, we aimed to determine the demographic and clinical characteristics of POMS in Poland as well as addressing some of its epidemiological aspects. Methods. A retrospective study was conducted based on the Polish Multiple Sclerosis Registry, considering a population of children and adolescents with MS (age ≤ 18 years). Data were collected by all 13 centres across Poland specializing in diagnosing and treating POMS. The actual course of the disease and its clinical properties were compared between child (≤12 years) and juvenile (>12 years) patients. MS onset and its prevalence were assessed at the end of 2019, stratified by age range. Results. A total of 329 paediatric or juvenile patients (228 girls, 101 boys) with a clinically definite diagnosis of MS, in conformity with the 2017 McDonald Criteria, were enrolled. For 71 children (21.6%), the first symptoms appeared before the age of 12. The female: male ratio increased with age, amounting to 1:1 in the ≤12 years group and to 2.9:1 in the >12 years group. In most cases, the disease had multi-symptomatic onset (31.3%), and its course was mostly of a relapsing–remitting character (95.7%). The initial Expanded Disability Status Score for both groups was 1.63 ± 1.1, whereas the annual relapse rate was 0.84 during the first 2 years. The time between the onset of symptoms and diagnosis was longer in the younger patients (8.2 ± 4.2 vs. 4.6 ± 3.6 months; p < 0.005). On 31 December 2019, the age-adjusted prevalence standardized to the European standard population was 5.19/100,000 (95% CI, 4.64–5.78). Significantly higher prevalence was noted in the 13–18 years group (7.12; 95% CI, 6.64–7.86) than in the 9–12 years group (3.41; 95% CI, 2.98–3.86) and the <9 years group (0.56; 95% CI, 0.46–0.64; p < 0.001). Conclusion. POMS commencing at the age of ≤12 years is rare, differing significantly from the juvenile-onset and adult MS in terms of clinical characteristics, course, and incidence, as stratified by gender.

show abstract

Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims

Cited by 14 publications

References 33 publications

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

Gender-Related Differences in Prodromal Multiple Sclerosis Characteristics: A 7-Year Observation Study

The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland

Contact Info

Product

Resources

About