Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone

Saidha, Shiv; Mok, Tzehow; Butler, Marcus W.; Fanning, N. F.; Harrington, Hugh

doi:10.1016/j.jocn.2009.09.026

Cited by 10 publications

(9 citation statements)

References 6 publications

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“…Previous reports have described cases of co‐occurrence of MS and PD, and a cohort study in Sweden even reported a 1.7‐fold increased relative risk of PD amongst MS patients. Interestingly, and in agreement with our findings, if the start of follow‐up in the Swedish study was postponed to 5 years after diagnosis of MS, no excess risk of PD amongst MS patients (SIR 0.66, 95% CI 0.24–1.44) was observed.…”

Section: Discussionmentioning

confidence: 95%

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Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study

Nielsen

Pasternak

Stenager

et al. 2013

Euro J of Neurology

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Section: Discussionmentioning

confidence: 95%

“…Several case reports and a Swedish cohort study have suggested a co‐occurrence of PD amongst persons with MS . Controversy remains, however, regarding the possible link between these two neurological diseases .…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study

Nielsen

Pasternak

Stenager

et al. 2013

Euro J of Neurology

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“…However, it is unclear how the interruption of WM function leads to atypical Parkinsonism. Nonetheless, Parkinsonian features occur in patients of vascular origin[2-4], in patients with traumatic etiology [5], in certain osmotic demyelinating syndromes such as central pontine and extrapontine myelinolysis [6], in various leukoencephalopathies including leukodystrophies and [7, 8], mitochondrial disorders [9], occasionally in neuroinflammatory diseases like multiple sclerosis [10], and in certain rare hereditary neurodegenerative conditions such as tremor-ataxia syndrome [11], spinocerebellar ataxia[12] and others. [13]…”

Section: Introductionmentioning

confidence: 99%

Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations

Sundal

Fujioka

Gerpen

et al. 2013

Parkinsonism & Related Disorders

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Atypical Parkinsonism associated with white matter pathology has been described in cerebrovascular diseases, mitochondrial cytopathies, osmotic demyelinating disorders, leukoencephalopathies including leukodystrophies, and others. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant disorder with symptomatic onset in midlife and death within a few years after symptom onset. Neuroimaging reveals cerebral white matter lesions that are pathologically characterized by non-inflammatory myelin loss, reactive astrocytosis, and axonal spheroids. Most cases are caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. We studied neuropathologically verified HDLS patients with CSF1R mutations to assess Parkinsonian features. Ten families were evaluated with 16 affected individuals. During the course of the illness, all patients had at least some degree of bradykinesia. Fifteen patients had postural instability, and seven had rigidity. Two patients initially presented with Parkinsonian gait and asymmetrical bradykinesia. These two patients and two others exhibited bradykinesia, rigidity, postural instability, and tremor (two with resting) early in the course of the illness. Levodopa/carbidopa therapy in these four patients provided no benefit, and the remaining 12 patients were not treated. The mean age of onset for all patients was about 45 years (range, 18-71) and the mean disease duration was approximately six years (range, 3-11). We also reviewed HDLS patients published prior to the CSF1R discovery for the presence of Parkinsonian features. Out of 50 patients, 37 had gait impairments, 8 rigidity, 7 bradykinesia, and 5 resting tremor. Our report emphasizes the presence of atypical Parkinsonism in HDLS due to CSF1R mutations.

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“…A number of case reports have been described, in which the relationship between these two diseases was either coincidental or casual. [ 4 5 6 7 8 9 10 11 12 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 4 ] A number of case reports has suggested a co-occurrence of MS and PD. [ 4 5 6 7 8 9 10 11 12 ] Two hypotheses have explained the link between these two diseases, one is the coincidental co-occurrence and the other is a casual relation, wherein. PD can develop because of the demyelinating plaque in the basal ganglia of MS patients.…”

Section: Introductionmentioning

confidence: 99%

Co-occurrence of multiple sclerosis and Parkinson disease

et al. 2016

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Parkinson disease (PD) is a neurodegenerative disease of the central nervous system (CNS) with the highest prevalence in adults over 60 years of age On the other hand multiple sclerosis (MS), which mostly affects individuals between 20 and 40 years of age, is another neurodegenerative and autoimmune disease of the CNS, however, less common than PD. Here we aim to report the case of a 39-year-old woman, who developed PD 18 years after diagnosis of MS.

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Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone

Cited by 10 publications

References 6 publications

Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study

Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study

Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations

Co-occurrence of multiple sclerosis and Parkinson disease

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