Multiple sclerosis enters a grey area

Pappalardo, Jenna L.; Hafler, David A.

doi:10.1038/d41586-019-00563-6

Cited by 5 publications

(4 citation statements)

References 13 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although MS studies have focused on alterations of the WM in the CNS for a long time, the role of the GM in MS has recently been illuminated. 83 A recent study identified that T cells reactive for protein b-synuclein are present in the GM of patients with progressive MS. 84 Progressive MS is characterized by both "motor" and "non-motor" symptoms, including cognitive impairments. The mechanistic details of many "non-motor" symptoms remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…83 A recent study identified that T cells reactive for protein b-synuclein are present in the GM of patients with progressive MS. 84 Progressive MS is characterized by both "motor" and "non-motor" symptoms, including cognitive impairments. Although MS studies have focused on alterations of the WM in the CNS for a long time, the role of the GM in MS has recently been illuminated.…”

Section: Symptomatic Narcolepsy In Nmosdmentioning

confidence: 99%

See 1 more Smart Citation

Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica

Kawachi

2019

Clinical & Exp Neuroim

View full text Add to dashboard Cite

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the two main autoimmune demyelinating disorders of the central nervous system. MS is defined as autoimmune oligodendrocytopathy (unknown autoantigens), and NMOSD is defined as autoimmune astrocytopathy or aquaporin-4 channelopathy. Both diseases can occur throughout the central nervous system, and do often cause various "motor" and "nonmotor" symptoms. "Non-motor" symptoms, including cognitive impairment, fatigue, pain and neuropsychological symptoms (e.g. depression, loneliness and anxiety), have gained renewed attention in MS and NMOSD since the past three decades, because they influence a patient's competence in daily life activities, including the participation in social activities and their employment status. Herein, we summarize the current concepts of the neuropathological processes of these "non-motor" symptoms in MS and NMOSD. These concepts help to define the novel disease-specific mechanisms of the two diseases, and to improve the quality of daily life of patients with MS and NMOSD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Symptomatic Narcolepsy In Nmosdmentioning

confidence: 99%

Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica

Kawachi

2019

Clinical & Exp Neuroim

View full text Add to dashboard Cite

show abstract

“…Multiple sclerosis (MS) has been recognized as a demyelinating and chronic central nervous system (CNS) disease that involves environmental and genetic factors, 1 causes various psychiatric disorders, 2 and affects over two million people across the world. 3 , 4 MS is mainly diagnosed in the third and fourth decades of life and is more prevalent among women as compared with men.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of obsessive-compulsive disorder prevalence in Iranian patients with multiple sclerosis and its relationship with demographic characteristics

Keyhani,

Shabani,

Etesam

et al. 2023

CJN

View full text Add to dashboard Cite

Background: The present study examined the prevalence of obsessive-compulsive disorder (OCD) among Iranian patients with multiple sclerosis (MS) and the relationship between OCD and the patient’s demographic characteristics. Methods: The present study used a cluster sampling method to randomly select 297 patients with MS from the patients referred to the MS Clinic and Research Center of Sina University Hospital, Tehran, Iran, during 2018-2019. To gather the required data, a questionnaire consisting of demographic characteristics and disease information sections was used. Moreover, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Obsessive-Compulsive Inventory-Revised (OCI-R), and Hospital Anxiety and Depression Scale (HADS) were employed in the present study. between OCD-positive and negative groups was examined with chi-square test and independent samples t-test, respectively. Binary logistic regression was used as multivariate modeling to adjust the effects of potential confounders that could distort the relation of OCD with intended variables. Data were analyzed using SPSS software. The significance level was considered lower than 0.05. Results: Of the total of 297 patients, 77.8% were women. Moreover, analysis of the data obtained from the HADS questionnaire revealed that 11.44% (n = 34) and 15.15% (n = 45) of patients had severe depression and severe anxiety, respectively. The results of Y-BOCS indicated that the prevalence of severe OCD among patients was 19.9%. The OCI-R questionnaire revealed that the prevalence of OCD was 47.8%, which was consistent with the total of moderate, severe, and extreme values of Y-BOCS (47.9%). Furthermore, the subscales of ordering-arranging with 69 patients (22.9%) and obsessing with 46 patients (15.5%) indicated the highest frequencies as compared to other subscales. Moreover, OCD had a significant relationship with depression, anxiety, and type of MS in this regard. Conclusion: In this study, the prevalence rate of OCD among patients with MS was higher than its rate among the general population.

show abstract

“…In this investigation, we explored the potential of this method for study of multiple sclerosis. Multiple sclerosis is a chronic inflammatory and demyelinating disease of the central nervous system (Dendrou et al, 2015; Pappalardo and Hafler, 2019). Multiple factors have been indicated for disease emergence and re-emergence, including autoimmune etiology, environmental factors, as well as specific genetic predispositions (Abbasalizad Farhangi et al, 2019; Agresti et al, 2019; Ahumada-Pascual et al, 2019; Kotelnikova et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Coupling the Paternò-Büchi (PB) Reaction With Mass Spectrometry to Study Unsaturated Fatty Acids in Mouse Model of Multiple Sclerosis

et al. 2019

View full text Add to dashboard Cite

Lipid dysregulation has been implicated in multiple sclerosis due to its involvement during and after inflammation. In this study, we have profiled fatty acids (FAs) in the mouse model of multiple sclerosis with new capabilities of assigning carbon-carbon double bond (C=C) location(s) and quantifying C=C location isomers. These new capabilities are enabled by pairing the solution phase Paternò-Büchi (PB) reaction that modifies C=C bonds in FAs, with tandem mass spectrometry (MS/MS), termed as PB-MS/MS. A series of unsaturated FAs and C=C location isomers have been identified, including FA17:1 (Δ10), FA18:1 (Δ9 and Δ11), FA18:2 (Δ9 and Δ12), and FA 20:4 (Δ5, Δ8, Δ11, Δ14). Notable differences in saturated and unsaturated FAs between normal and experimental autoimmune encephalomyelitis (EAE) mice spinal cords have been detected. Furthermore, the effects of hydralazine, a scavenger of acrolein, on profile changes of FAs in mice were studied. Increased Δ11-to-Δ9 isomer ratios for FA 18:1 were noted in the diseased samples as compared to the control. The present work provides a facile and robust analytical method for the quantitation of unsaturated FAs as well as identification of FA C=C location isomers, which will facilitate discovering prospective lipid markers in multiple sclerosis.

show abstract

Multiple sclerosis enters a grey area

Cited by 5 publications

References 13 publications

Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica

Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica

Evaluation of obsessive-compulsive disorder prevalence in Iranian patients with multiple sclerosis and its relationship with demographic characteristics

Coupling the Paternò-Büchi (PB) Reaction With Mass Spectrometry to Study Unsaturated Fatty Acids in Mouse Model of Multiple Sclerosis

Contact Info

Product

Resources

About