Multiple Sclerosis disease distribution and potential impact of environmental air pollutants in Georgia

Gregory, Anthony; Shendell, Derek G.; Okosun, Ike S.; Gieseker, Karen E.

doi:10.1016/j.scitotenv.2008.01.065

Cited by 49 publications

(43 citation statements)

References 48 publications

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“…Regarding the meteorological variables, the air temperature showed a negative correlation with hospitalizations and the relative humidity a positive correlation with admissions of patients between 30 and 50 years and of male gender. These results agree with others studies, such as that of Angelici et al 16 , which demonstrated a positive relation between PM 10 and MS admissions in Lombardy, Italy, and that of Gregory et al 3 , which showed a positive relation between PM 10 and female patient admissions. o Adjustments of the multiple linear regression model with the stepwise method Before the development of multiple linear regression, residual analysis was performed to verify the adjustment of hospitalization data and PM 10 to the model, since residuals should follow a normal distribution for the model 11,17,24 .…”

Section: Resultssupporting

confidence: 93%

“…After the Kolmogorov-Smirnov test indicated normal distribution of data, the variables PM 10 , relative humidity, air temperature, and hospital admissions due to MS were correlated using Pearson's model 14,15 . Although many studies that correlate air pollution and meteorological variables with diseases use the Poisson family of generalized linear models (MLG), in this study we used multiple linear regression 3,16,17 . This model was chosen because the variables have a normal distribution and, according to the residue analysis, the model was adequate for our data 11,13,17 .…”

Section: Materials and Methods O Meteorological Datamentioning

confidence: 99%

“…The more accepted pathogenic hypothesis is that MS may be the result of a particular combination of genetic predisposition and action of unknown environmental factors that, when present in the same individual, may lead to this dysfunction of the neurological system 2,3,4 . The involvement of the neurological system can cause the patient with MS to suffer relapses.…”

Section: Introductionmentioning

confidence: 99%

“…Not having a known and well-defined etiology, MS is investigated worldwide. Studies show that there are possible relationships between air pollution and hospital admissions for MS relapses, because particulate materials present in the atmosphere can increase the systemic inflammatory response and neuro-inflammation 3,7,8 . Among the particulate pollutants, particulate matter (PM 10 ) is a pollutant classified as inhalable particles considered harmful to human health because they can be deposited in the upper respiratory tract 9 .…”

Section: Introductionmentioning

confidence: 99%

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Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Diniz¹,

Frony-Macedo²,

Piacenti-Silva³

2017

Arch Health Invest

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Introduction: Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system, which in some cases may be characterized by recurrent relapses of inflammation that cause mild to severe neurological disability. Some studies around the world have associated the increase of systemic inflammatory responses and neuro-inflammation of patients with exposure to high levels of particulate matter (PM 10 ) and certain conditions of temperature and humidity. Materials and methods: The objective of this study was to verify the influence of the concentration of PM 10 and meteorological variables (air temperature and relative humidity) on the number of hospitalizations for MS in the city of São Paulo. Data from 2008 to 2016, which passed through descriptive statistics and inferences, were used as multiple linear regression models. Results: The models obtained indicated a positive relation (p < 0.01) in the number of hospitalizations with the increase of PM 10 and relative humidity, showing that 31.23% of hospital admissions can be explained by these variables. Conclusion: These results are important, since there are no other studies from Brazil that correlate meteorological and air quality variables with MS. Descriptors: Air Pollution; Multiple Sclerosis; Linear Models. ResumoIntrodução: A Esclerose Múltipla (EM) é uma doença crônica, inflamatória e desmielinizante do sistema nervoso central, que em alguns casos pode ser caracterizada por surtos recorrentes de inflamação que causam leve a grave deficiência neurológica. Alguns estudos em todo o mundo têm associado o aumento de respostas inflamatórias sistêmicas e neuroinflamação de pacientes quando expostos a altos níveis de material particulado (MP 10 ) e certas condições de temperatura e umidade. Material e Método: O objetivo deste estudo foi verificar a influência da concentração de material particulado (MP 10 ) e das variáveis meteorológicas (temperatura do ar e umidade relativa) sobre o número de internações por EM na cidade de São Paulo. Para isso foram utilizados dados destas no período de 2008 a 2016, os quais passaram por estatísticas descritivas e inferencias, como modelos de regressão linear múltipla. Resultados: Os modelos obtidos indicaram relação positiva (p <0,01) no número de internações com o aumento do material particulado MP 10 e umidade relativa, demonstrando que 31,23% das internações hospitalares podem ser explicadas por essas variáveis. Conclusão: Esses resultados são importantes, pois até agora, em nosso conhecimento, no Brasil não existem estudos que correlacionem as variáveis meteorológicas e de qualidade do ar com a Esclerose Múltipla. Descritores: Poluição do Ar; Esclerose Múltipla; Modelos Lineares. ResumenIntroducción: La esclerosis múltiple (EM) es una enfermedad del sistema crónica, inflamatoria y desmielinizante nervioso central, que en algunos casos puede ser caracterizada mediante recaídas recurrentes de inflamación causando leve a déficit neurológico grave. Algunos estudios de todo el mundo q...

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Section: Resultssupporting

confidence: 93%

Section: Materials and Methods O Meteorological Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Diniz¹,

Frony-Macedo²,

Piacenti-Silva³

2017

Arch Health Invest

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show abstract

“…To our knowledge, the current study is the first to have looked at potential sources through industrial output and examine childhood exposure and MS risk. In other adult MS studies, increased exposure to larger particulate matter (PM 10 ) was related to both increased risk for MS in adults20, 23 and MS relapse using hospitalization records 18, 19, 24…”

Section: Discussionmentioning

confidence: 99%

Urban air quality and associations with pediatric multiple sclerosis

Lavery

Waubant

Casper

et al. 2018

Ann Clin Transl Neurol

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BackgroundWe previously identified air quality as a risk factor of interest for pediatric multiple sclerosis. The purpose of this study is to more closely examine the association between the six criteria air pollutants and pediatric MS as well as identify specific areas of toxic release using data from the Toxic Release Inventory.MethodsPediatric MS cases (N = 290) and healthy controls (N = 442) were included as part of an ongoing case–control study. We used the National Emissions Inventory system to estimate particulate exposure by county of residence for each participant. Proximity to Toxic Release Inventory (TRI) sites was also assessed using ArcGIS mapping tools. Risk‐Screening Environmental Indicators (RSEI) classified counties at risk to exposure of environmental toxic releases.ResultsFine particulate matter (PM 2.5), carbon monoxide (CO), sulfur dioxide (SO 2), and lead air emissions were associated with increased odds for pediatric MS (P < 0.01) for those residing within 20 miles of an MS center. Most study participants (75%) resided within 5 miles of at least one TRI site; however, the mean total pounds of stack air releases was higher for sites near MS cases (81,000 tons) compared to those near healthy controls (35,000 tons, P = 0.002). Average RSEI scores did not differ significantly between cases and controls.ConclusionOut of several air pollutants examined, we show that fine particulate matter and three other criteria pollutants (SO 2, CO, and lead) were statistically associated with higher odds for pediatric MS.

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Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines

Liu

Zhao

Zhou

et al. 2022

J of Applied Toxicology

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Nitrosamines were a class of important environmental carcinogens associated with digestive tract neoplasms. As the early toxic effect of nitrosamines, inflammatory response participated in the malignant transformation of cells and promoted the occurrence and development of tumors. However, the role of NLRP3 inflammasome in the nitrosamines-induced inflammatory response was unclear. In this study, the human esophageal epithelial cells (Het-1A) were used to explore potential mechanisms of the activation of NLRP3 inflammasome under co-exposure to nine nitrosamines commonly found in drinking water at the doses of 0, 4, 20, 100, 500, and 2500 ng/mL. The results showed that nitrosamines stimulated activation of the NLRP3 inflammasome and induced cellular oxidative damage in a dose-dependent manner. Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species (mtROS) scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mtROS. Furthermore, we found that nitrosamines co-exposure also promoted cell pyroptosis through the NLRP3/caspase-1/GSDMD pathway, which was demonstrated by adding the caspase-1 inhibitor Z-YVAD-FMK and constructing NLRP3 downregulated Het-1A cell line. This study revealed the underlying mechanism of the activation of NLRP3 inflammasome initiated by nitrosamines co-exposure and provided new perspectives on the toxic effects of nitrosamines.

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Multiple Sclerosis disease distribution and potential impact of environmental air pollutants in Georgia

Cited by 49 publications

References 48 publications

Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil

Urban air quality and associations with pediatric multiple sclerosis

Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines

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