Multiple Sclerosis as the Cause of Sudden ‘Pontine’ Deafness

Drulović, BoŽIdar; Ribarič-Jankes, Ksenija; Kostić, Vladimir; Šternić, Nadežda

doi:10.3109/00206099409071880

Cited by 26 publications

(11 citation statements)

References 15 publications

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“…This is consistent with Noffsinger et al [1], as well as research on the general population [3,[6][7], which suggests that most hearing losses are bilateral rather than unilateral. It does, however, contradict case-study reports of individuals with MS presenting sudden Sensorineural hearing loss [24][25][26][27][28][29][30][31][32][33][34][35][36]. In those reports, the loss was typically unilateral but returned to normal or previous HLs after a given period of time (sometime after the exacerbation in symptoms).…”

Section: Discussioncontrasting

confidence: 44%

“…The most common type of hearing loss (after normal hearing) for the group of subjects with MS and for the group of control subjects without MS was sensorineural hearing loss. This is the most common type of hearing loss typically reported in articles of both individuals with and without MS. Additionally, this type of hearing loss is consistent with the disease process of MS and prior investigations have suggested that sensorineural hearing loss in individuals with MS is due to swelling and/or scarring in the lower portions of the central auditory pathways or in the cochlear nerve [24,26,28,30,[33][34][37][38] …”

Section: Discussionmentioning

confidence: 49%

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Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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Abstract-The purpose of the present investigation was to determine whether differences exist in audiometric hearing status between individuals with and without multiple sclerosis (MS) and between individuals with relapsing-remitting MS (RRMS) and individuals with secondary progressive MS (SPMS). Forty-seven subjects with MS (26 with RRMS and 21 with SPMS) and forty-nine control subjects without MS completed both a comprehensive case-history questionnaire and a conventional hearing evaluation. Statistical analyses, accounting for the potential confounding factors of age, sex, noise exposure, and use of ototoxic medications, revealed significant differences in hearing thresholds between subjects with and without MS at select audiometric test frequencies (p < 0.05). At these audiometric test frequencies, the subjects with MS had poorer hearing thresholds. Additional analyses revealed significant differences in hearing sensitivity at select audiometric frequencies between the subjects with RRMS and the subjects with SPMS, such that those with SPMS had poorer hearing thresholds. These findings have significant clinical implications for practitioners working with patients with MS.

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Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 49%

Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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“…Hearing loss, as judged by the pure tone audiometry, is a rare presentation in MS (up to 4%) and, in most cases, transient (Drulovic et al, 1994;Franklin et al, 1989;Morgenstern et al, 1995;Robinette & Facer, 1991;Stach & Delgado-Vilches, 1993), resulting from a lesion in the auditory nerve root entry zone (ponto-medullary junction) or at the cochlear nucleus level. A proximal lesion would unlikely lead to a hearing impairment, due to bilateral (predominantly contralateral) distribution of the afferent fibers above this level.…”

Section: Discussionmentioning

confidence: 99%

“…The root entry zone (pontomedullar junction) is the only myelinated portion of the cochlear nerve and a plaque at this site leads to unilateral hearing loss (Drulovic et al, 1994;Marangos, 1996;Yamasoba et al, 1997). The brain stem.…”

mentioning

confidence: 99%

Auditory Efferent Function Is Affected in Multiple Sclerosis

Coelho

Ćeranić²,

Prasher

et al. 2007

Ear &Amp; Hearing

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This study provides the evidence for a deficit of efferent auditory function in the majority of patients with MS. Taking into consideration the possible roles of the MOC system in processing of auditory information, abnormal MOC suppression in patients with MS may explain a variety of auditory presentations that are currently largely overlooked. This study also highlights the diagnostic value of the MOC suppression test as a site-of-lesion diagnostic test in MS and in identifying subtle brain stem lesions undetected by MRI, suggesting that subtle brain stem lesions may exist and that the MOC suppression test is sufficiently sensitive to detect them. Accordingly, the MOC suppression test may provide a tool for an early diagnosis of MS.

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“…MS-related damage involving the eighth cranial nerves, cochlear nuclei and the pons has been reported to cause sudden changes in studies evaluating auditory thresholds for pure-tone audiometry [Doty et al, 2012;Drulovic et al, 1993Drulovic et al, , 1994. A recent study claimed that there is no chronic deafness in MS patients [Doty et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

Deafness in Patients with Multiple Sclerosis

Leite

Melo

et al. 2014

Audiol Neurotol

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Multiple sclerosis (MS) is a demyelinating disease and is considered the most debilitating neurological disorder among young adults. Sudden deafness has been reported in MS patients. This article describes cases of sudden deafness related to acute bouts in MS patients. A survey was conducted using 405 records of MS patients attended to at a reference center in the city of Rio de Janeiro between 2011 and 2012 to identify cases of sudden deafness. Seven patients were identified, 6 with a relapsing-remitting course and 1 with progressive disease at onset. Five patients had unilateral deafness and 2 bilateral. The recovery was complete in 4 and partial in 1, and there was no recovery in 2 patients. It was not possible to establish a topographical correlation between deafness and brainstem lesions. Audiometric examinations revealed severe hearing loss during the bout and recovery of hearing in 5 cases after remission.

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Multiple Sclerosis as the Cause of Sudden ‘Pontine’ Deafness

Cited by 26 publications

References 15 publications

Audiometric hearing status of individuals with and without multiple sclerosis

Audiometric hearing status of individuals with and without multiple sclerosis

Auditory Efferent Function Is Affected in Multiple Sclerosis

Deafness in Patients with Multiple Sclerosis

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