Multiple Sclerosis and Polyarteritis

Meloff, Keith L.

doi:10.1001/archneur.1980.00500610066015

Cited by 2 publications

(2 citation statements)

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“…Although involvement of general organs in MS has been reported, its implication in disease pathogenesis is not clear. In addition, demyelinating diseases similar to MS have been occasionally reported in systemic autoimmune diseases, such as autoimmune thyroid disease, myasthenia gravis, rheumatoid arthritis and systemic lupus erythematosus (SLE) (Achari et al, 1976;Aita et al, 1974;Meloff, 1980;Tanphaichitr, 1980). Hypocomplementemia and circulating immune complexes have also been demonstrated in MS (Tachovsky et al, 1976;Tanphaichitr, 1980).…”

Section: Discussionmentioning

confidence: 99%

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Peterson

Tsunoda

Masaki

et al. 2007

Journal of Neuroimmunology

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Two myelin oligodendrocyte glycoprotein ) monoclonal antibodies (mAbs) were produced from an A.SW mouse with progressive experimental autoimmune encephalomyelitis. Polyreactivity/specificity of the mAbs was demonstrated by ELISA. Functionality and a potential role in pathogenesis of systemic autoimmunity were demonstrated in vitro in a lymphocytotoxicity assay and in vivo upon injection into naïve mice. Injection of MOG mAb producing hybridomas into naïve mice resulted in immunoglobulin deposition in kidneys and liver. This model will be useful in determining whether transitional forms between CNS (organ)-specific and systemic autoimmune diseases exist, and whether progressive multiple sclerosis has features of a systemic autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Peterson

Tsunoda

Masaki

et al. 2007

Journal of Neuroimmunology

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“…Support for a link between CNS and systemic autoimmune disease is provided by reports of CNS antibodies, inflammation and/or demyelinating disease similar to MS in systemic autoimmune diseases, such as myasthenia gravis, rheumatoid arthritis, autoimmune thyroid disease and SLE [7-12]. Involvement of organs outside the CNS in the pathogenesis of MS is not clear and systemic autoimmune contributions have not been explored.…”

Section: Introductionmentioning

confidence: 99%

Cross-reactive myelin antibody induces renal pathology

et al. 2008

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Experimental autoimmune encephalomyelitis (EAE) is an autoimmune model for multiple sclerosis (MS). Previously, we reported renal immunoglobulin (Ig) deposition in mice with myelin oligodendrocyte glycoprotein ) induced progressive-EAE and naïve mice injected with MOG 92-106 hybridoma cells producing antibody that cross-reacts with various autoantigens including double-stranded DNA. To assess whether MOG 92-106 antibodies actually induce kidney changes, the extent of renal Ig deposition and changes in glomerular histology and filtration were investigated. Mice with progressive-EAE exhibited Ig deposition, glomerular hypercellularity and proteinuria indicating kidney dysfunction. MOG 92-106 hybridoma cell injected mice also had Ig in the kidneys and proteinuria. Therefore, sensitization with MOG 92-106 and transfer of MOG [92][93][94][95][96][97][98][99][100][101][102][103][104][105][106] antibodies can induce both central nervous system and renal pathology. The renal involvement reported in MS is believed to occur as a side effect of nephrotoxic drugs or neurogenic bladder. Our results demonstrate that an autoimmune response against myelin could induce pathologic changes in the kidney and may help explain renal changes reported in patients with progressive MS.

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Multiple Sclerosis and Polyarteritis

Cited by 2 publications

References 1 publication

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Cross-reactive myelin antibody induces renal pathology

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