Multiple Sclerosis and Fatigue

Cook, Karon F.; Bamer, Alyssa M.; Roddey, Toni S.; Kraft, George H.; Kim, Jiseon; Amtmann, Dagmar

doi:10.1016/j.pmr.2013.06.006

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Previous reports have determined that self-reported fatigue increases but that walking performance does not change from morning to afternoon in people with MS. 32,33 A few studies have shown decreased performance of usual activities in people with MS who report high levels of fatigue. 1,11,15,34 Although these studies effectively demonstrated a relationship between fatigue and daily activity in MS, the effect of differing fatigue levels on functional performance remained unclear. We determined that individuals with MS who scored greater than 10 on the MFIS-5 (group HF) took longer to perform the TUG test, reported decreased balance confidence in performing daily activities, and demonstrated a greater impact of with low levels of fatigue.…”

Section: Resultsmentioning

confidence: 99%

Associations Between Fatigue and Disability, Functional Mobility, Depression, and Quality of Life in People with Multiple Sclerosis

Garg¹,

Bush²,

Gappmaier³

2016

International Journal of MS Care

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Section: Resultsmentioning

confidence: 99%

Associations Between Fatigue and Disability, Functional Mobility, Depression, and Quality of Life in People with Multiple Sclerosis

Garg¹,

Bush²,

Gappmaier³

2016

International Journal of MS Care

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“…The SF severity can be affected by personal (eg, depression) and environmental factors (eg, ambient temperature); severe fatigue negatively impacts quality of life. 11,12 However, changes in SF severity are not easily measurable due to its subjectivity and its physical, mental, and emotional dimensions. 9 Common characterizations link the experience of SF to its impact as seen in this definition: "a subjective lack of physical and/or mental energy that is perceived by the individual or caregiver to interfere with usual and desired activities."…”

Section: Introductionmentioning

confidence: 99%

“…PwMS typically experience SF as tiredness or loss of physical or mental energy. The SF severity can be affected by personal (eg, depression) and environmental factors (eg, ambient temperature); severe fatigue negatively impacts quality of life 11,12. However, changes in SF severity are not easily measurable due to its subjectivity and its physical, mental, and emotional dimensions 9.…”

Section: Introductionmentioning

confidence: 99%

Self-Report Measures of Fatigue for People With Multiple Sclerosis: A Systematic Review

Cohen

Matsuda²,

Fritz³

et al. 2023

Journal of Neurologic Physical Therapy

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Background and Purpose: The symptom of fatigue impairs function in people with multiple sclerosis (MS). Choosing appropriate measures to assess fatigue is challenging. The purpose of this article is to report the findings of a systematic review of patient-reported fatigue measures for people with MS. Methods: PubMed, CINAHL, and Embase databases were searched through January 2020 using terms related to fatigue and MS. Studies were included if the sample size was 30 or more or smaller samples if adequately powered, and if information about measurement characteristics (ie, test-retest reliability, content validity, responsiveness, interpretability, or generalizability) of the measure(s) could be extracted. Study quality was appraised with the 2-point COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. Data about measurement characteristics, psychometrics, and clinical utility were extracted and results were synthesized. Results: Twenty-four articles met inclusion criteria with information about 17 patient-reported fatigue measures. No studies had critical methodologic flaws. Measurement characteristic data were not available for all measures. Clinical utility varied in time to complete and fatigue domains assessed. Discussion and Conclusions: Five measures had data pertaining to all properties of interest. Of these, only the Modified Fatigue Impact Scale (MFIS) and Fatigue Severity Scale (FSS) had excellent reliability, responsiveness data, no notable ceiling/floor effects, and high clinical utility. We recommend the MFIS for comprehensive measurement and the FSS for screening of subjective fatigue in people with MS. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A443).

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“…In contrast to tiredness, fatigue describes the overwhelming feeling of exhaustion, which manifests both cognitively and physically and does not resolve with rest or sleep. With up to 80% probability of occurrence, it is also one of the most common symptoms of multiple sclerosis 1 . MS is a primarily neuroinflammatory disease of the central nervous system with neurodegenerative features.…”

Section: Introductionmentioning

confidence: 99%

Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis

Linnhoff

Haghikia

Zaehle

2023

Sci Rep

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Fatigue is associated with a dramatically decreased quality of life in people with multiple sclerosis (pwMS). It refers to a constant subjective feeling of exhaustion and performance decline, known as fatigability. However, inconsistency and heterogeneity in defining and assessing fatigue have led to limited advances in understanding and treating MS-associated fatigue. Transcranial direct current stimulation (tDCS) has emerged as a promising, non-pharmaceutical treatment strategy for subjective fatigue. However, whether repetitive tDCS also have long-term effects on time-on-task performance has not yet been investigated. This pseudorandomized, single-blinded, and sham-controlled study investigated tDCS effects on behavioral and electrophysiological parameters. 18 pwMS received eight twice-weekly 30 min stimulations over the left dorsolateral prefrontal cortex. Fatigability was operationalized as time-on-task-related changes in reaction time variability and P300 amplitude. Additionally, subjective trait and state fatigue ratings were assessed. The results revealed an overall decrease in subjective trait fatigue ratings that lasted at least four weeks after the stimulations. However, the ratings declined after both anodal and sham tDCS. No effects were found on subjective state fatigue and objective fatigability parameters. Linear Mixed Models and Bayesian Regression models likewise favored the absence of a tDCS effect on fatigability parameters. The results confirm the complex relationship between MS-associated fatigue and fatigability. Reliable and clinically relevant parameters need to be established to extend the potential of tDCS for treating fatigability. Furthermore, our results indicate that consecutive stimulations rather than twice-weekly stimulations should be the preferred stimulation scheme in future studies.

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Multiple Sclerosis and Fatigue

Cited by 9 publications

References 16 publications

Associations Between Fatigue and Disability, Functional Mobility, Depression, and Quality of Life in People with Multiple Sclerosis

Associations Between Fatigue and Disability, Functional Mobility, Depression, and Quality of Life in People with Multiple Sclerosis

Self-Report Measures of Fatigue for People With Multiple Sclerosis: A Systematic Review

Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis

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