Multiple sclerosis and alcohol use disorders: in-hospital mortality, extended hospital stays, and overexpenditures

Alcohol is well known for promoting systemic inflammation and aggravating multiple chronic health conditions. Thus, alcohol may also be expected to serve as a risk factor in autoimmune diseases. However, emerging data from human and animal studies suggest that alcohol may in fact be protective in autoimmune diseases. These studies point toward alcohol's complex dosedependent relationship in autoimmune diseases as well as potential modulation by duration and type of alcohol consumption, cultural background and sex. In this review, we will explore alcohol's pro-and anti-inflammatory properties in human and animal autoimmune diseases, including autoimmune diabetes, thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, experimental autoimmune encephalomyelitis and multiple sclerosis. We will also discuss potential mechanisms of alcohol's anti-inflammatory effects mediated by the gut microbiome.

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“… 57 Conversely, high doses of alcohol may contribute to increased risk of MS, particularly in men. 58 , 59 …”

Section: Protective Role Of Light-moderate Dose Of Alcohol In Autoimmune Diseasesmentioning

confidence: 99%

Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome?

et al. 2021

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“…Still, we note that correlations of the CDT4 and MDR with NK cell count are modest. Nevertheless, whether any of these metrics predict future disease associated with impaired immune cell function, such as chronic bronchitis, in this population, is unknown, and alcohol consumption has both pro- and anti-inflammatory effects whose exact impact is disease- and dose-dependent [ 57 , 61 , 62 ]. However, we believe that these data support the future use of ATS and these cell count measures for developing a more granular understanding of the relationship of alcohol consumption to inflammatory-related illness in longitudinal populations with DNA biobanks.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic and Proteomic Biomarkers of Elevated Alcohol Use Predict Epigenetic Aging and Cell-Type variation Better Than Self-Report

Beach

Ong

Gibbons

et al. 2022

Genes

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Excessive alcohol consumption (EAC) has a generally accepted effect on morbidity and mortality, outcomes thought to be reflected in measures of epigenetic aging (EA). As the association of self-reported EAC with EA has not been consistent with these expectations, underscoring the need for readily employable non-self-report tools for accurately assessing and monitoring the contribution of EAC to accelerated EA, newly developed alcohol consumption DNA methylation indices, such as the Alcohol T Score (ATS) and Methyl DetectR (MDR), may be helpful. To test that hypothesis, we used these new indices along with the carbohydrate deficient transferrin (CDT), concurrent as well as past self-reports of EAC, and well-established measures of cigarette smoking to examine the relationship of EAC to both accelerated EA and immune cell counts in a cohort of 437 young Black American adults. We found that MDR, CDT, and ATS were intercorrelated, even after controlling for gender and cotinine effects. Correlations between EA and self-reported EAC were low or non-significant, replicating prior research, whereas correlations with non-self-report indices were significant and more substantial. Comparing non-self-report indices showed that the ATS predicted more than four times as much variance in EA, CDT4 cells and B-cells as for both the MDR and CDT, and better predicted indices of accelerated EA. We conclude that each of the non-self-report indices have differing predictive capacities with respect to key alcohol-related health outcomes, and that the ATS may be particularly useful for clinicians seeking to understand and prevent accelerated EA. The results also underscore the likelihood of substantial underestimates of problematic use when self-report is used and a reduction in correlations with EA and variance in cell-types.

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Multiple sclerosis and alcohol use disorders: in-hospital mortality, extended hospital stays, and overexpenditures

Cited by 2 publications

References 44 publications

Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome?

Alcohol as friend or foe in autoimmune diseases: a role for gut microbiome?

Epigenetic and Proteomic Biomarkers of Elevated Alcohol Use Predict Epigenetic Aging and Cell-Type variation Better Than Self-Report

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