Multiple Sclerosis After X-radiation: Activation by Treatment of Metastatic Glomus Tumor

McMeekin, Robert R.; Hardman, John; Kempe, Ludwig G.

doi:10.1001/archotol.1969.00770030619017

Cited by 20 publications

(7 citation statements)

References 4 publications

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“…A commonly cited figure is 4%, according to Borsanyi, 18 who reviewed 200 glomus cases 18 . Approximately 30 cases have been reported as having metastases from a temporal bone glomus 19–41 . The most common locations for metastases are lymph nodes, skeleton, lungs, and liver 17 .…”

Section: Introductionmentioning

confidence: 99%

Malignant Glomus Tumors

Manolidis

Shohet

Jackson³

et al. 1999

The Laryngoscope

138

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Section: Introductionmentioning

confidence: 99%

Malignant Glomus Tumors

Manolidis

Shohet

Jackson³

et al. 1999

The Laryngoscope

138

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“…Additionally, a 2013 case report suggested that conventional doses of ionising radiation used to treat meningioma induced the onset of multiple sclerosis in a 43-year-old woman, suggesting a potential connection but not establishing a causal relationship [185]. Other case and cohort studies have indicated a similar trend [186][187][188][189]. One cohort study even found that X-ray exposure site was relevant, with chest X-rays, skull X-rays, and brain CT scans all aligning with a higher incidence of MS [190].…”

Section: Figurementioning

confidence: 99%

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Boyd

Byrne

Middleton

et al. 2021

Cells

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Microglia, the innate immune cells of the central nervous system, play a pivotal role in the modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases of the CNS, including Alzheimer’s disease and Parkinson’s disease. It is well documented that microglial activation, initiated by a variety of stressors, can trigger a potentially destructive neuroinflammatory response via the release of pro-inflammatory molecules, and reactive oxygen and nitrogen species. However, the potential anti-inflammatory and neuroprotective effects that microglia are also thought to exhibit have been under-investigated. The application of ionising radiation at different doses and dose schedules may reveal novel methods for the control of microglial response to stressors, potentially highlighting avenues for treatment of neuroinflammation associated CNS disorders, such as Alzheimer’s disease and Parkinson’s disease. There remains a need to characterise the response of microglia to radiation, particularly low dose ionising radiation.

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“…In a similar case report, MS symptoms were elevated in a patient after radiotherapy for parotid carcinoma ( Murphy et al, 2003 ). Moreover, a patient initially diagnosed for a glomus jugulare tumor showed an exacerbation of quiescent MS following radiotherapy ( McMeekin et al, 1969 ). These results can be due to the reported development of disseminated plaques of demyelination, which is seen after radiotherapy ( McMeekin et al, 1969 ).…”

Section: Role Of Ionizing Radiation In Multiple Sclerosismentioning

confidence: 99%

“…Moreover, a patient initially diagnosed for a glomus jugulare tumor showed an exacerbation of quiescent MS following radiotherapy ( McMeekin et al, 1969 ). These results can be due to the reported development of disseminated plaques of demyelination, which is seen after radiotherapy ( McMeekin et al, 1969 ). However, similar lesions can be seen in MS patients because of underlying a pre-disposition to demyelination.…”

Section: Role Of Ionizing Radiation In Multiple Sclerosismentioning

confidence: 99%

Role of Ionizing Radiation in Neurodegenerative Diseases

Sharma

Mathur

et al. 2018

Front. Aging Neurosci.

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Ionizing radiation (IR) from terrestrial sources is continually an unprotected peril to human beings. However, the medical radiation and global radiation background are main contributors to human exposure and causes of radiation sickness. At high-dose exposures acute radiation sickness occurs, whereas chronic effects may persist for a number of years. Radiation can increase many circulatory, age related and neurodegenerative diseases. Neurodegenerative diseases occur a long time after exposure to radiation, as demonstrated in atomic bomb survivors, and are still controversial. This review discuss the role of IR in neurodegenerative diseases and proposes an association between neurodegenerative diseases and exposure to IR.

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Multiple Sclerosis After X-radiation: Activation by Treatment of Metastatic Glomus Tumor

Cited by 20 publications

References 4 publications

Malignant Glomus Tumors

Malignant Glomus Tumors

Control of Neuroinflammation through Radiation-Induced Microglial Changes

Role of Ionizing Radiation in Neurodegenerative Diseases

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