Multiple sclerosis

Filippi, Massimo; Bar‐Or, Amit; Piehl, Fredrik; Preziosa, Paolo; Solari, Alessandra; Vukusic, Sandra; Rocca, Maria A.

doi:10.1038/s41572-018-0041-4

Cited by 885 publications

(848 citation statements)

References 349 publications

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“…MS is a chronic autoimmune disease characterized by inflammation, demyelination, and axonal degeneration in the CNS (Correale, Gaitan, Ysrraelit, & Fiol, 2017;Filippi et al, 2018). Several strong lines of evidence point to a role for Notch in cellular processes critical for MS.…”

Section: Oligodendrocytes and Msmentioning

confidence: 99%

The Notch pathway in CNS homeostasis and neurodegeneration

Artavanis‐Tsakonas

Louvi

2019

WIREs Developmental Biology

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The role of the Notch signaling pathway in neural development has been well established over many years. More recent studies, however, have demonstrated that Notch continues to be expressed and active throughout adulthood in many areas of the central nervous system. Notch signals have been implicated in adult neurogenesis, memory formation, and synaptic plasticity in the adult organism, as well as linked to acute brain trauma and chronic neurodegenerative conditions. NOTCH3 mutations are responsible for the most common form of hereditary stroke, the progressive disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Notch has also been associated with several progressive neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Although numerous studies link Notch activity with CNS homeostasis and neurodegenerative diseases, the data thus far are primarily correlative, rather than functional. Nevertheless, the evidence for Notch pathway activity in specific neural cellular contexts is strong, and certainly intriguing, and points to the possibility that the pathway carries therapeutic promise. This article is categorized under: Nervous System Development > Flies Signaling Pathways > Cell Fate Signaling Nervous System Development > Vertebrates: General Principles

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Section: Oligodendrocytes and Msmentioning

confidence: 99%

The Notch pathway in CNS homeostasis and neurodegeneration

Artavanis‐Tsakonas

Louvi

2019

WIREs Developmental Biology

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“…Multiple sclerosis (MS) is a chronic auto-inflammatory demyelinating disease, in which nerves are damaged by demyelination in the CNS [79]. MS patients show abnormalities in motor function, muscle weakness, and sensorimotor dysfunction [80].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research

Cheon

Kim

et al. 2020

IJMS

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Cognitive symptoms are prevalent in the elderly and are associated with an elevated risk of developing dementia. Disease-driven changes can cause cognitive disabilities in memory, attention, and language. The inflammasome is an innate immune intracellular complex that has a critical role in the host defense system, in that it senses infectious pathogen-associated and endogenous danger-associated molecular patterns. An unbalanced or dysregulated inflammasome is associated with infectious, inflammatory, and neurodegenerative diseases. Due to its importance in such pathological conditions, the inflammasome is an emerging drug target for human diseases. A growing number of studies have revealed links between cognitive symptoms and the inflammasome. Several studies have shown that reducing the inflammasome component mitigates cognitive symptoms in diseased states. Therefore, understanding the inflammasome regulatory mechanisms may be required for the prevention and treatment of cognitive symptoms. The purpose of this review is to discuss the current understanding of the inflammasome and its relationships with cognitive symptoms in various human diseases.

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“…Multiple sclerosis (MS) is a leading cause of neurological disability in young adults, affecting more than 2.3 million people worldwide 1 . The pathology of MS is characterized by the periodic disruption of the blood-brain barrier and infiltration of immune cells, including T cells, B cells and macrophages, into the central nervous system (CNS) resulting in demyelination, neuroaxonal degeneration and neurological deficits.…”

Section: Introductionmentioning

confidence: 99%

Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology

Zheleznyakova

Piket

Needhamsen

et al. 2020

Preprint

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Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS), is associated with dysregulation of microRNAs (miRNA). We here analyzed all classes of small non-coding RNAs (sncRNAs) in matching peripheral blood mononuclear cells (PBMCs), plasma, cerebrospinal fluid (CSF) cells and cell-free CSF from relapsing-remitting (RRMS, n=12 in relapse, n=11 in remission), secondary progressive (SPMS, n=6) MS patients and noninflammatory and inflammatory neurological disease controls (NINDC, n=11; INDC, n=5). We show widespread changes in small nuclear, nucleolar, transfer RNAs and miRNAs. In CSF cells, 133/133 and 115/117 differentially expressed sncRNAs are increased in RRMS relapse compared to remission and RRMS compared to NINDC, respectively. In contrast, 65/67 differentially expressed PBMC sncRNAs are decreased in RRMS compared to NINDC. The striking contrast between periphery and CNS suggests that sncRNA-mediated mechanisms, including alternative splicing, RNA degradation and mRNA translation, regulate the transcriptome of pathogenic cells primarily in the target organ.

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Multiple sclerosis

Cited by 885 publications

References 349 publications

The Notch pathway in CNS homeostasis and neurodegeneration

The Notch pathway in CNS homeostasis and neurodegeneration

Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research

Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology

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