Multiple Sclerosis

Abstract

This monograph by a British neurologist, a general physician, and a pathologist, respectively, is an important survey of our present knowledge of multiple sclerosis and a distillation of the experience and opinions of the authors. After a brief but discriminating historical note, they discuss the curious and unexplained geographical distribution of the disease, the putative etiological factors, the complex symptomatology as observed in both clinic and laboratory, and the problems of

The natural history of multiple sclerosis

“…It has become commonplace in recent years to adapt McAlpine's original schematic 6 to indicate that relapses leave a succession of residual deficits, following which the chronic progressive phase supervenes with a takeoV point in midscale. Re-inspection of his original graphs is warranted.…”

Multiple sclerosis prevalence and mortality in Allegheny County for 1965 and 1966.

“…In the studies of Chipman and Kurland, as well as that of Ipsen, 30 to 40 per cent of the patients were identified through local physicians. Second, the existence of the two multiple sclerosis societies in Allegheny County provides an additional major data source which was not available to Ipsen and Kurland in 1949, and this source identified only 4 per cent of the patients in Chipman's study in 1959. Approximately one-third of Ipsen's cases (14 per 100,000) were identified by physician only, while nearly 50 per cent in Allegheny County (24 per 100,000) were identified only by the two multiple sclerosis societies.…”

“…Acheson, summarizing 14 studies, found multiple sclerosis DECEMBER, 19970 prevalence in females to be 1.4 times that in males. 4 In the northern United States, the prevalence rate for nonwhites approximates that of whites while, in the South, Negroes appear to be afflicted significantly less often. However, this difference might well be an artifact attributable to sociologic and diagnostic factors, especially differences in medical care.…”

Ressonância magnética na esclerose múltipla: análise de 270 casos

“…No Brasil, presume-se que a incidência seja baixa, isto é, inferior a 5 casos para cada 100 mil habitantes. Contudo, os neurologistas, particularmente aqueles do Sudeste e Sul do Brasil, têm-se deparado com um número cada vez maior destes casos, talvez porque estejam cada vez mais influenciados pelos critérios clínicos já bem mais divulgados e discutidos no meio médico [4][5][6] , bem como pela crescente e mais rotineira aplicação dos exames paraclínicos, em particular a ressonância magnética que se definiu como o método de imagem mais importante para o diagnóstico da EM [7][8][9] .…”