Multiple sclerosis 2017 McDonald criteria are also relevant for Tunisians

Souissi, Amira; Mrabet, S.; Nasri, Amina; Larnaout, F.; Bendjebara, Mouna; Gargouri, Amina; Kacem, Imen; Gouider, Riadh

doi:10.1016/j.msard.2020.102161

Cited by 3 publications

(15 citation statements)

References 32 publications

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“…By evaluating a large multicenter cohort of patients with typical CIS, 8 our study demonstrated that the 2017 McDonald criteria had higher sensitivity, lower specificity, and overall similar accuracy in predicting conversion to CDMS than the 2010 McDonald criteria. This validation study extends previous studies, 9,12,14 which are characterized by high between-study variability performance of the different criteria, possibly due to the heterogeneity in the demographic and clinical characteristics of the patients evaluated, the MRI protocols used to define MRI criteria, lengths of the follow-ups, statistical approaches used, and the influence of treatment.…”

Section: Discussionsupporting

confidence: 79%

“…McDonald criteria. This validation study extends previous studies, 9,12,14 which are characterized by high between-study variability performance of the different criteria, possibly due to the heterogeneity in the demographic and clinical characteristics of the patients evaluated, the MRI protocols used to define MRI criteria, lengths of the follow-ups, statistical approaches used, and the influence of treatment.…”

Section: Discussionsupporting

confidence: 78%

“…After their publication, several studies compared the performance of the 2017 and 2010 revisions to the McDonald criteria in adult [9][10][11][12][13][14] and pediatric patients with CIS. [15][16][17] Globally, they showed that the 2017 McDonald criteria have higher sensitivity but lower specificity compared with the 2010 criteria in predicting clinically definite MS (CDMS), but a shorter time to MS diagnosis.…”

Section: Classification Of Evidencementioning

confidence: 99%

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Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome

et al. 2022

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Background and ObjectivesTo compare the performance of the 2017 revisions to the McDonald criteria with the 2010 McDonald criteria in establishing MS diagnosis and predicting prognosis in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).MethodsCSF examination, brain and spinal cord MRI obtained ≤5 months from CIS onset, and a follow-up brain MRI acquired within 15 months from CIS onset were evaluated in 785 CIS patients from 9 European centers. Date of second clinical attack and of reaching Expanded Disability Status Score (EDSS) ≥ 3.0, if they occurred, were also collected. Performance of the 2017 and 2010 McDonald criteria for dissemination in space (DIS), time (DIT) (including oligoclonal bands assessment) and DIS + DIT for predicting a second clinical attack (clinically definite [CD] MS) and EDSS ≥ 3.0 at follow-up was evaluated. Time to MS diagnosis for the different criteria was also estimated.ResultsAt follow-up (median = 69.1 months), 406/785 CIS patients developed CDMS. At 36 months, the 2017 DIS + DIT criteria had higher sensitivity (0.83 vs 0.66), lower specificity (0.39 vs 0.60) and similar area under the curve values (0.61 vs 0.63). Median time to MS diagnosis was shorter with the 2017 vs the 2010 or CDMS criteria (2017 revision = 3.2; 2010 revision = 13.0; CDMS = 58.5 months). The 2 sets of criteria similarly predicted EDSS ≥ 3.0 milestone. Three periventricular lesions improved specificity in patients ≥45 years.DiscussionThe 2017 McDonald criteria showed higher sensitivity, lower specificity and similar accuracy in predicting CDMS compared to 2010 McDonald criteria, while shortening time to diagnosis of MS.Classification of EvidenceThis study provides Class II evidence that the 2017 McDonald Criteria more accurately distinguish CDMS in patients early after a CIS when compared to the 2010 McDonald criteria.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 78%

Section: Classification Of Evidencementioning

confidence: 99%

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Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome

et al. 2022

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“…As observed by other authors 22–27 (Table 3), our data showed higher sensitivity for the 2017 McDonald criteria than the 2010 criteria, shortening the time-to-diagnosis of MS and treatment, as well as preventing new relapses and accumulation of disability. Inclusion of CSF OCB assessment significantly increased sensitivity, 17 an effect that grew over time, indicating that a longer follow-up improves criteria efficacy.…”

Section: Discussionsupporting

confidence: 89%

“…Median time between symptom onset and baseline imaging was 16 days (IQI1-3 5. [25][26][27][28][29][30][31][32][33][34][35][36][37][38]. Baseline spinal cord MRI was performed in 185 patients (92%), and OCBs assessed in 126 (63%).…”

Section: Resultsmentioning

confidence: 99%

Performance of McDonald 2017 multiple sclerosis diagnostic criteria and evaluation of genetic ancestry in patients with a first demyelinating event in Argentina

Marrodán¹,

Piedrabuena²,

Gaitán³

et al. 2023

Mult Scler

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Background: Information on performance of multiple sclerosis (MS) diagnostic criteria is scarce for populations from Latin America, Asia, or the Caribbean. Objective: To assess performance of revised 2017 McDonald criteria as well as evaluate genetic ancestry in a group of MS patients from Argentina experiencing a debut demyelinating event. Methods: Demographic and clinical characteristics, cerebrospinal fluid (CSF), and magnetic resonance imaging (MRI) findings and new T2 lesions were recorded at baseline and during relapses. Diagnostic accuracy in predicting conversion to clinically defined MS (CDMS) based on initial imaging applying revised 2017 criteria was evaluated and genetic ancestry-informative markers analyzed. Results: Of 201 patients experiencing their first demyelinating event (median follow-up 60 months), CDMS was confirmed in 67. We found 2017 diagnostic criteria were more sensitive (84% vs 67%) and less specific (14% vs 33%) than 2010 criteria, especially in a group of patients revised separately, presenting positive oligoclonal bands (88% vs 8%). Genetic testing performed in 128 cases showed 72% of patients were of European ancestry and 27% presented genetic admixture. Conclusion: 2017 McDonald criteria showed higher sensitivity and lower specificity compared with 2010 criteria, shortening both time-to-diagnosis and time-to-treatment implementation.

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Leistungsfähigkeit der McDonald-Kriterien von 2017

et al. 2022

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Zusammenfassung Hintergrund Die schnelle und zuverlässige Diagnose einer Multiplen Sklerose (MS) ist entscheidend, um eine angepasste verlaufsmodifizierende Therapie zu beginnen. Die 2017-Revision der McDonald-Kriterien hat das Ziel, eine einfachere und frühzeitigere MS-Diagnose mit hoher diagnostischer Genauigkeit zu ermöglichen. Ziel der Arbeit/Fragestellung In der vorliegenden Arbeit wurden die publizierten Arbeiten, die die Anwendung der McDonald-Kriterien von 2017 und 2010 miteinander verglichen haben, ausgewertet und bezüglich der diagnostischen Leistungsfähigkeit analysiert. Material und Methoden Mittels Literaturrecherche in der PubMed-Datenbank (Suchbegriff: McDonald criteria 2010 and McDonald criteria 2017) wurden 20 Studien und ein Übersichtsartikel mit insgesamt 3006 auswertbaren Patienten identifiziert. Ergebnisse Bei Anwendung der McDonald-Kriterien von 2017 konnte die Diagnose einer MS bei mehr Patienten (2277/3006 Patienten, 76 %) und in einem früheren Stadium (3–10 Monate) verglichen mit der Revision von 2010 (1562/3006 Patienten, 52 %) gestellt werden. Von den zusätzlichen MS-Diagnosen sind 193/715 auf die Anpassung der bildgebenden Kriterien der zeitlichen Dissemination und 536/715 auf die Einführung der oligoklonalen Banden als diagnostisches Kriterium zurückführen. Diskussion Die revidierten McDonald-Kriterien von 2017 erlauben die Diagnosestellung einer MS bei einem höheren Anteil an Patienten beim ersten klinischen Ereignis.

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Multiple sclerosis 2017 McDonald criteria are also relevant for Tunisians

Cited by 3 publications

References 32 publications

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome

Performance of McDonald 2017 multiple sclerosis diagnostic criteria and evaluation of genetic ancestry in patients with a first demyelinating event in Argentina

Leistungsfähigkeit der McDonald-Kriterien von 2017

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