Multiple retention deficits following one-trial appetitive training

Wansley, Richard A.; Holloway, Frank

doi:10.1016/s0091-6773(75)90135-2

Cited by 58 publications

(22 citation statements)

References 15 publications

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“…Unfortunately, none of these studies includes a systematic range 01' training-testing intervals during the 24 h following training, as in Holloway and Wansley's aversive conditioning experiments. In arecent experiment, however, Wansley and Holloway (1975) interval during the 24 h following training, and they obtained a phasic retention function similar to that found in their aversive paradigms (Holloway & Wansley, 1973a, b). They deprived rats of water for 24 h prior to one-trial appetitive maze training in which 5-min access to water was the reinforcer and tested for retention at intervals of 0.25, 1,6, 12, 18, or 24 h. Retention at 0.25, 1, 12, and 24 h was greater than at 6 and 18 h.…”

supporting

confidence: 71%

“…Second, motivational factors (deprivation time) must be controlled across the various intervals to prevent an interaction with possible retention fluctuations. Wansley and Holloway (1975) resolved the first problem but possibly not the second. They allowed all groups to have lO-min access to water 1 h prior to training, and 1 h prior to testing gave another lO-min access to water for all groups except those tested at 0.25 and 1 h. This procedure was designed to equate the degree of deprivation across groups, although the possibility of differing deprivation levels exists because the rats in the various groups were deprived to differing degrees at the time of the 10-min free access period, in addition to the obvious problems for the 0.25-and l-h conditions.…”

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confidence: 96%

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Multiple deficits in the retention of an appetitively motivated behavior across a 24-h period in rats

Hunsicker

Mellgren

1977

Animal Learning & Behavior

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Recent investigations have found a multiphasic retention function associated with avoidance training (e.g., Holloway & Wansley, 1973a, bl, The present experiment was done to determine if a similar retention function also describes appetitively motivated behavior. Rats were allowed access to preferred solution in the shock compartment of a passive avoidance apparatus. Then either .25 h after the appetitive preexposure or at successive 3-h intervals up to 24 h, the rats were administeredone-trialpassive avoidancetraining consisting of a strong shock presented in the shock compartment. The retention of the appetitive preexposure was determined by its effect on performance of the passive avoidance task as measured 24 hafter the shock trial. The results dernonstrated that the retention function associated with the appetitive preexposure was phasic with an altemation between high and low retention every 12 h. Specifically, retention was higher after the .25·, 9-, 12-, and 24-h intervals than after 3·, 6-, 15-, and 18-h intervals. These results are consistent with prior research on the retention of avoidancetraining.

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confidence: 71%

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confidence: 96%

Multiple deficits in the retention of an appetitively motivated behavior across a 24-h period in rats

Hunsicker

Mellgren

1977

Animal Learning & Behavior

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“…However, we think this is not the case, since this type of masking effect would presumably be present in tone-cued fear conditioning and is not apparent. Although this may be resolved by additional groups trained at one ZT but tested at another, this would result in comparing animals with different training-testing intervals, which can lead to different performances (Holloway & Wansley, 1973a, 1973bWansley & Holloway, 1975, 1976.…”

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confidence: 99%

“…passive avoidance learning (Holloway & Wansley, 1973a, 1973bWansley & Holloway, 1976), as well as one-trial appetitivelearning (Wansley & Holloway, 1975), have been well characterized. These retention deficits represent an inability of the animal to retrieve the memory of a learning experience when the training-testing delay is at non-24-h intervals and are flattened by lesions of the suprachiasmatic nucleus (the master biological clock in mammals; Stephan & Kovacevic, 1978).…”

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Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Valentinuzzi

Kolker²,

Vitaterna³

et al. 2001

Animal Learning & Behavior

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“…Day/night cycle CIRCADIAN organization may play a critical role in memory processes [4,5,9,10]. Thus phase-shifting circadian rhythms in rats shortly after passive avoidance training impaired their performance during retention testing, suggesting that disrupting circadian organization produces retrograde amnesia [9].…”

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confidence: 99%

Disrupting circadian rhythms in rats induces retrograde amnesia

Fekete

Ree

Niesink

et al. 1985

Physiology & Behavior

103

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WIED. Disrupting circadian rhythms in rats induces retrograde amnesia. PHYSIOL BEHAV 34(6) [883][884][885][886][887] 1985.--Disrupting circadian organization in rats by phase-shifting the illumination cycle or by exposure to a reversed day/night cycle or to continuous light, resulted in retrograde amnesia for passive avoidance behavior. This retrograde amnesia induced by phase-shifting lasted at least 2 days, and gradually diminished the longer the rats were exposed to the new illumination cycle. Retention performance was not impaired when rats were exposed to phase-shifting for 3-5 days before the learning trial. The retrograde amnesia due to changing the illumination cycle is probably due to retrieval disturbances. Extinction of active avoidance behavior was facilitated in rats exposed to a phase-shifted illuminiation cycle, but social and explorative behavior of rats tested in dyadic encounters were not affected by changing the normal illumination cycle. It is concluded that phase-shifting may result in amnesia for newly learned behavioral responses, but not for more innate behavioral patterns. Circadian organizationRetrograde amnesia Active avoidance behavior Passive avoidance behavior Social behavior Day/night cycle CIRCADIAN organization may play a critical role in memory processes [4,5,9,10]. Thus phase-shifting circadian rhythms in rats shortly after passive avoidance training impaired their performance during retention testing, suggesting that disrupting circadian organization produces retrograde amnesia [9]. In the present experiments we used the passive avoidance test procedure to analyse memory processes of rats, and disturbed circadian organization of the animals by changing the usual light/dark illumination schedule. The studies were designed, (1) to compare the effects of phaseshifting the light/dark cycle with those of constant exposure to light and of a reversed day/night cycle, (2) to analyse the duration of the amnesia induced by phase-shifting, (3) to investigate whether the phase-shifting-induced amnesia is due to disturbances of learning, consolidation, and/or retrieval processes, (4) to analyse the specificity of the impaired performance as observed in the passive avoidance procedure, by studying the effect of changing the normal light/dark cycle on extinction of active avoidance behavior, as well as on social and explorative behavior of rats tested in dyadic encounters. METHOD AnimalsMale Wistar rats of an inbred strain (CPB-TNO, Zeist, The Netherlands) weighing 130-150 g, were used. The animals housed 5-6 per cage at room temperature (20--21°C) under ad lib food and water conditions. In the animal colony the lights were on from 6 a.m. to 8 p.m. All observations were made between 8 a.m. and noon, except when otherwise indicated. During experimentation the rats were housed identically, except that the periods that the lights were on and off were changed. The following illumination conditions were used: reversed day/night cycle: lights on from 8 p.m. to 6 a.m., constant light: lights on f...

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Multiple retention deficits following one-trial appetitive training

Cited by 58 publications

References 15 publications

Multiple deficits in the retention of an appetitively motivated behavior across a 24-h period in rats

Multiple deficits in the retention of an appetitively motivated behavior across a 24-h period in rats

Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Disrupting circadian rhythms in rats induces retrograde amnesia

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