Multiple Recurrences and Late Metastasis of Adamantinoma in the Tibia: A Case Report

Giannoulis, DK; Gantsos, Apostolos; Giotis, Dimitrios; Nk, Paschos; Vagionas, Anastasios; Arnaoutoglou, CM; Pentheroudakis, George; Xenakis, Theodoros

doi:10.1177/230949901402200330

Cited by 12 publications

(10 citation statements)

References 17 publications

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“…The most common complications are infection, allograft consolidation failure, and fracture. 21 , 22 In this case series, we obtained a lower rate of complications than that found in the literature. We reported one (14.2%) case of infection.…”

Section: Discussionsupporting

confidence: 47%

Tibial Adamantinoma: Analysis of Seven Consecutive Cases in a Single Institution

et al. 2018

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Objective:Adamantinoma accounts for less than 1% of the primary bone neoplasms. The tibia is the most affected bone and it is predominant in male patients between the second and third decades of life. The objective of this study is to obtain epidemiological and clinical information on patients with adamantinoma of the tibia treated surgically between 1989 and 2016.Methods:Retrospective series of seven patients diagnosed with adamantinoma of the tibia that underwent surgery at the orthopedic oncology service of our hospital. The information was obtained from the medical records and histopathological reports of our institution.Results:A total of 2870 medical records with histological reports were evaluated. Seven cases of adamantinoma of the tibia were included. The mean age was 28.5 (17-49) years. We found a predominance of females (71.4%) and the most affected side was the left one, with four cases (57.1%). The biopsy revealed bone adamantinoma in four (57.1%) patients, while the diagnosis of the other patients was confirmed after the histological examination of the surgical specimen. All the patients underwent surgery as definitive treatment. No positive margins were reported. No local recurrence (LR) was reported and two patients had distant metastasis (DM).Conclusion:The prognosis of survival in cases of adamantinoma of the tibia is high. The rates of LR and DM were low. Surgical treatment with extensive tumor resection is the treatment of choice. Level of Evidence IV, Case Series.

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Section: Discussionsupporting

confidence: 47%

Tibial Adamantinoma: Analysis of Seven Consecutive Cases in a Single Institution

et al. 2018

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“…Adamantinoma is a rare, low-grade malignant neoplasm that arises in the tibia, fibula or both bones, although it has rarely been reported in other bones [ 36 ]. Adamantinoma accounts for 0.3–1 % of all malignant bone tumours and occurs mostly in young to middle-aged adults (20–40 years of age), with a male-to female ratio of 1.3:1.…”

Section: Classification Of Bone Sarcomasmentioning

confidence: 99%

“…Recurrence is late (can be >20 years) but frequent (about 30 %) after incomplete excision. The rate of metastasis is 10 % to 20 %, usually to lung [ 36 ].…”

Section: Classification Of Bone Sarcomasmentioning

confidence: 99%

UK guidelines for the management of bone sarcomas

et al. 2016

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This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommendations by the European Society of Medical Oncology, The National Comprehensive Cancer Network and The National Institute for Health and Care Excellence have been incorporated, and the literature since 2010 reviewed. The standards represent a consensus amongst British Sarcoma Group members in 2015. It is acknowledged that these guidelines will need further updates as care evolves. The key recommendations are that bone pain or a palpable mass should always lead to further investigation and that patients with clinico-radiological findings suggestive of a primary bone tumour at any site in the skeleton should be referred to a specialist centre and managed by a fully accredited bone sarcoma multidisciplinary team. Treatment recommendations are provided for the major tumour types and for localised, metastatic and recurrent disease. Follow up schedules are suggested.

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“…Due to the slow-growing nature of adamantinomas, local recurrences and metastases have been documented in the literature up to 36 years after the original diagnosis [ 8 , 9 , 39 – 43 ]. Therefore, long-term surveillance (>15 years) is warranted in these patients as was highlighted by the late metastases observed in the present case [ 14 , 23 , 41 , 44 ]. Furthermore, imaging of the lungs and physical examination for lymphadenopathy may be considered on an annual basis or at the time of local recurrence to monitor for metastases [ 10 ].…”

Section: Discussionmentioning

confidence: 90%

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Southam

Crawford

Billmire

et al. 2018

Case Reports in Orthopedics

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Adamantinoma is a rare, low-grade malignant tumor of the bone which grows slowly and typically occurs in the diaphysis of long bones, particularly in the tibia. Adamantinomas have the potential for local recurrence and may metastasize to the lungs, lymph nodes, or bone. We report a case of a 14-year-old female with a tibial adamantinoma who underwent wide resection with limb salvage and has subsequently been followed up for 18 years. The patient went on to have both a local soft tissue recurrence 5 years after the resection and metastases to both an inguinal lymph node and the right lower lobe of the lung 8 years after that recurrence, all of which have been treated successfully with marginal resections. Unique to this case, the patient was also incidentally found to have chromophobe-type renal cell carcinoma when undergoing a partial nephrectomy to resect a presumed metastasis of her adamantinoma. Genetic testing has not revealed any known genetic predisposition to cancer.

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Multiple Recurrences and Late Metastasis of Adamantinoma in the Tibia: A Case Report

Cited by 12 publications

References 17 publications

Tibial Adamantinoma: Analysis of Seven Consecutive Cases in a Single Institution

Tibial Adamantinoma: Analysis of Seven Consecutive Cases in a Single Institution

UK guidelines for the management of bone sarcomas

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

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